Lab run twitter of the Lim Lab | Yale University Dept of @YaleNeuro & @YaleGenetics | @Yale_INP | @MCDB_Yale | https://xitter.cf/t.co/cj7xxz0qnq
New Haven, CT
Joined June 2022
- Tweets91
- Following96
- Followers212
- Likes108
Lim Lab retweeted
Neurons aren't the whole story in SCA1. 🧠
In our new @jclinicalinvest paper, we show that mutant ataxin-1 in oligodendrocytes alone drives demyelination & motor deficits.
Read here: jci.org/articles/view/195723
Thanks to @Janghoolim, @YaleMed & co-authors! @LimLabYale @LeonTejwani
Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease driven by polyglutamine expansion in ataxin-1.
doi.org/10.1172/JCI195723
Here, Changwoo (Chris) Lee @chchrislee, Janghoo Lim @Janghoolim @LimLabYale & team provide strong evidence on the role of oligodendrocyte-specific expression of pathogenic ATXN1 in neuronal malfunction and systemic dysfunction in mouse models of this incurable disease.
The image: Purkinje cell torpedoes and myelin debris in the granular layer are increased in OL-SCA1-934 cKI mice.
@LeonTejwani
#SCA1 #Ataxin1
Lim Lab retweeted
Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease driven by polyglutamine expansion in ataxin-1.
doi.org/10.1172/JCI195723
Here, Changwoo (Chris) Lee @chchrislee, Janghoo Lim @Janghoolim @LimLabYale & team provide strong evidence on the role of oligodendrocyte-specific expression of pathogenic ATXN1 in neuronal malfunction and systemic dysfunction in mouse models of this incurable disease.
The image: Purkinje cell torpedoes and myelin debris in the granular layer are increased in OL-SCA1-934 cKI mice.
@LeonTejwani
#SCA1 #Ataxin1
Lim Lab retweeted
CONGRATS 🎉 to @YaleNeuro's Sreeganga Chandra (@SChandraLab), @Janghoolim, & Stephen Strittmatter, who recently received funding 💰 from the Blavatnik Family Foundation for their innovative research in the field of #neuroscience! 🧠
More 👇
ventures.yale.edu/news/blava…
Lim Lab retweeted
Today is #RareDiseaseDay which is meant to bring awareness to rare diseases around the world, including the various types of #Ataxia! How are you championing Rare Disease Day today?
For more information on Rare Disease Day, visit: rarediseaseday.org/
Lim Lab retweeted
#TraineeTuesday REWIND ⏪
Look back at the highlight of Vaishnavi Veeranki @vveeranki1, postgrad in the @LimLabYale! She is now a graduate student at University of California Irvine, where she continues her research journey! 🧠🤓
Read More👇
medicine.yale.edu/neuroscien…
Lim Lab retweeted
Bill Nye is adding his voice to #IAAD and sharing his family’s story with Ataxia in a brand new video. Help Bill Nye change the world for those living with Ataxia by liking & sharing: youtu.be/E0IBGdhDM-I
Lim Lab retweeted
We are thrilled to share our 2023 Annual Report, showcasing a year of significant progress and accomplishments at the National Ataxia Foundation.
Read the full 2023 Annual Report here: ataxia.org/wp-content/upload…
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Lim Lab retweeted
We had such a great time at our annual Department of Neuroscience Retreat last week! Check out the pictures 📸 We couldn't wait for the official photos...
Our @YaleNeuro community enjoyed a 2-day retreat by the seaside, attending talks 🗣️ and posters, and spending time together.
ALT Picture of a sunset dinner from the annual Department of Neuroscience Retreat
ALT Picture of attendees during a Neuroscience presentation
ALT A group of neuroscientists seated around a dinner table
ALT Graduate students of the neuroscience community posing for a group picture
Lim Lab retweeted
This #TraineeTuesday, meet Vaishnavi Veeranki @vveeranki1, a postgraduate associate in @LimLabYale! She recently got accepted into the neuroscience PhD program at @UCIrvine, where she will be furthering her research career in cellular and molecular biosciences.🥳[1/5]
Lim Lab retweeted
Congrats to Ben Sanders (@PrinceoPiermont), this week's #TraineeTuesday! Ben, a grad student in @LimLabYale, recently received the @NIHAging F31 fellowship for his research on #microglia and Nemo-Like Kinase in Alzheimer's Disease!! Let's dive into his research journey [1/5]
ALT Headshot of Ben Sanders
Lim Lab retweeted
Yale researchers report many gene expression changes that develop over the course of a neurodegenerative disorder called spinocerebellar ataxia type 1, which mainly affects the cerebellum. Read more ⬇️
@Janghoolim @SStevenWang @LeonTejwani @david_van_dijk
medicine.yale.edu/intmed/new…
Lim Lab retweeted
A collaborative study (@YaleNeuro, @YaleGenetics @YaleCompsci) reports the many gene expression changes that develop over the course of a neurodegenerative disorder called spinocerebellar ataxia type 1, shedding light on its progression. @NeuroCellPress medicine.yale.edu/neuroscien…
Lim Lab retweeted
So, so excited to finally be able to share the published version of our SCA1 snRNA-seq manusript, published today in @NeuroCellPress : cell.com/neuron/fulltext/S08…! A short thread below:
Lim Lab retweeted
Questions about neuroscience grad school program at Yale? faculty positions at @YaleNeuro? @KavliAtYale fellowships and resources? Hear current grad students debating their favorite New Haven pizza? Visit our grad school booth #73, Hall E, 12-2pm, Sat-Tue!
Lim Lab retweeted
In his #TraineeTuesday highlight last year, Victor Olmos (@LimLabYale) revealed why his research on spinocerebellar ataxia type 1 (a rare neurodegenerative disorder) felt personal. Huntington’s disease, another dominantly inherited polyglutamine disease, runs in his family [1/4]
ALT Quote from Victor Olmos: "What I find the most important about my work to me is the similarity of SCA1 to my family’s disease. I find that the similarity of the disease I study makes the work I do more personal and helps drive me."
Just out in @hmg_journal: we utilize bulk RNAseq to demonstrate dysregulation of🧬alternative splicing🧬in spinocerebellar ataxia type 1 #SCA1
Congratulations to our grad student Victor Olmos and additional authors who contributed to this work!🎉
academic.oup.com/hmg/advance…
Lim Lab retweeted
@MarinaP63 of #yalepsych and @YaleMed has been named director of Yale's Interdepartmental Neuroscience Program, the largest doctoral program in the biological and biomedical sciences at the university. bit.ly/3PvpG7N
Lim Lab retweeted
Nlk reduction clears aggregated neuronal TDP-43 in Lou Gehrig's disease: buff.ly/4490J5Z
@LeonTejwani @jysub53 @Janghoolim @Sowmith28302701 @LuhanNi9 @chchrislee @PrinceoPiermont @Yangfei_Lab @KimLuttik @Sophistarete @hannahhyeowon @ItsClaraLiao @LimLabYale
#Genetics
Lim Lab retweeted
Researchers identify a novel function of Nemo-like kinase (Nlk) as a negative regulator of lysosome biogenesis. Genetic or pharmacological (ASO) reduction of Nlk increased lysosome formation & improved clearance of aggregated TDP-43; Nlk destabilizes TFEB
jci.org/articles/view/138207
Lim Lab retweeted
Excited to finally share the in-press preview of one of the papers from my PhD work in the @LimLabYale , published at @jclinicalinvest : jci.org/articles/view/138207! Long story short, we identified a novel role for NLK in negatively regulating lysosomal gene expression in neurons🧠
Lim Lab retweeted
This week's #TraineeTuesday ⭐ is PhD candidate Chris Lee (@ChrispyChad) (@LimLabYale), who recently won a @NAF_Ataxia Graduate Research Fellowship!😊 Let's dive into his exciting research on the mechanisms underlying neurodegenerative diseases➡️ [1/5]
ALT Headshot of Chris Lee