@LinialMichal

Computational Biology and Bioinformatics at the Hebrew University.

 Jerusalem, ISRAEL
michal-linial.huji.ac.il/
Joined October 2019
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Our review on #StatisticalGenetics is now on #arXiv. We list & discuss major open problems in human trait genetics, touching on #GWAS, #PolygenicRiskScore, #heritability, #RareVariants, #epistasis and more. arxiv.org/abs/2108.06684

Open Problems in Human Trait Genetics

Genetic studies of human traits have revolutionized our understanding of the variation between individuals, and opened the door for numerous breakthroughs in biology, medicine and other scientific...

arxiv.org
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Michal Linial retweeted
Nadav Brandes@BrandesNadav4 Aug 2021
Our recent paper on the genetics of cancer risk is now published in Scientific Reports. A thread... 1/20 nature.com/articles/s41598-0…

Genetic association studies of alterations in protein function expose recessive effects on cancer...

Scientific Reports - Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition

nature.com
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Body mass index and birth weight improve polygenic risk score for type 2 diabetes medrxiv.org/content/10.1101/… Combined PRS with early-life measurements and separately considering males and females improve the utility of T2D -PRS..

Body mass index and birth weight improve polygenic risk score for type 2 diabetes

One of the major challenges in the post-genomic era is elucidating the genetic basis of human diseases. In recent years, studies have shown that polygenic risk scores (PRS), based on aggregated...

medrxiv.org
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We introduce FABRIC cancer portal. A ranked catalog of gene selection in tumors over the human coding genome in biorxiv.org/content/10.1101/… . For a cancer-centric view on known and overlooked cancer genes, visit fabric-cancer.huji.ac.il.

The FABRIC Cancer Portal: A Ranked Catalogue of Gene Selection in Tumors over the Human Coding...

We present The FABRIC Cancer Portal, a comprehensive catalogue of gene selection in cancer covering the entire human coding genome (~18,000 protein-coding genes) across 33 cancer types and pan-canc...

biorxiv.org
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Recessive effects in cancer predisposition exposed by genome-wide and proteome-wide association studies biorxiv.org/content/10.1101/… GWAS and PWAS reveal known and novel cancer-type regions with cancer predisposition signals, many of which display recessive heritability.

Recessive effects in cancer predisposition exposed by genome-wide and proteome-wide association...

The characterization of germline genetic variation affecting cancer risk, known as cancer predisposition, is fundamental to preventive and personalized medicine. Current attempts to detect cancer...

biorxiv.org
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Recessive effects in cancer predisposition exposed by genome-wide and proteome-wide association studies. GWAS and PWAS reveal known and novel cancer-type regions with cancer predisposition signals, many of which display recessive heritability. biorxiv.org/content/10.1101/…

Recessive effects in cancer predisposition exposed by genome-wide and proteome-wide association...

The characterization of germline genetic variation affecting cancer risk, known as cancer predisposition, is fundamental to preventive and personalized medicine. Current attempts to detect cancer...

biorxiv.org
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De novo STXBP1 mutation in a child with developmental delay and spasticity reveals a major structural alteration in… pubmed.ncbi.nlm.nih.gov/3281…

De novo STXBP1 mutation in a child with developmental delay and spasticity reveals a major struct...

STXBP1, also known as Munc-18, is a master regulator of neurotransmitter release and synaptic function in the human brain through its direct interaction with syntaxin 1A. STXBP1 binds syntaxin 1A is...

pubmed.ncbi.nlm.nih.gov
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BIRD: identifying cell doublets via biallelic expression from single cells academic.oup.com/bioinformat…

BIRD: identifying cell doublets via biallelic expression from single cells

ABSTRACTSummary. Current technologies for single-cell transcriptomics allow thousands of cells to be analyzed in a single experiment. The increased scale o

academic.oup.com
bioRxiv viewer disq.us/t/3qjan1g On Spliceosome-associated miRNAs, breast cancer cells (MCF-10A, MCF-7, MDA-MB-231) and some overlooked nuclear targets.
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PWAS: Proteome-Wide Association Study biorxiv.org/content/10.1101/…

PWAS: Proteome-Wide Association Study

Over the last two decades, GWAS (Genome-Wide Association Study) has become a canonical tool for exploratory genetic research, generating countless gene-phenotype associations. Despite its accomplis...

biorxiv.org
Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A @Preprints_org preprints.org/manuscript/202…
My article is featured on the @ResearchGate #COVID19 community page. Read it here: researchgate.net/publication…

(PDF) The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor

PDF | The COVID-19 disease has plagued over 200 countries with over three million cases and has resulted in over 200,000 deaths within 3 months. To gain... | Find, read and cite all the research you...

researchgate.net
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Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A Multivariable Analysis medrxiv.org/content/10.1101/…

Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A...

COVID-19 started in Hubei province in China and has spread to 210 countries within 3 months. The statistic of COVID-19 across the world is reported daily, providing a dynamic perspective for each...

medrxiv.org
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Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A Multivariable Analysis medrxiv.org/content/10.1101/…

Significantly Improved COVID-19 Outcomes in Countries with Higher BCG Vaccination Coverage: A...

COVID-19 started in Hubei province in China and has spread to 210 countries within 3 months. The statistic of COVID-19 across the world is reported daily, providing a dynamic perspective for each...

medrxiv.org
The SARS-CoV-2 exerts a distinctive strategy for interacting with the ACE2 human receptor biorxiv.org/content/10.1101/…

The SARS-CoV-2 exerts a distinctive strategy for interacting with the ACE2 human receptor

The COVID-19 disease has plagued over 110 countries and has resulted in over 4,000 deaths within 10 weeks. We compare the interaction between the human ACE2 receptor and the SARS-CoV-2 spike protein...

biorxiv.org
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The SARS-CoV-2 exerts a distinctive strategy for interacting with the ACE2 human receptor disq.us/t/3muq27v
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