Utilizing droplet co-cultivation of archaeal-bacterial consortia, attempting to reenact eukaryogenesis and to look deeper into cross-domain interactions.
Copenhagen, Denmark
Joined December 2018
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Great first dat at the #EMBO workshop on Molecular Biology of #Archaea #MBoA2024 Many inspiring talks and discussions - looking forward to the coming days! If here, pop by poster 16 for a chat about using droplet cultures to study the promiscuity of Asgards #villumfonden
Great day for collecting #sediment in my search for #archaea. Took the bike to honor #vicyklertilarbejde - keeping it green @VILLUMFONDEN @DTUbioengineer
Had a great time representing @cemist_dtu and @DTUbioengineer for #forskningensdøgn at @DTUtweet yesterday. Always fun sharing our work and passion while hopefully inspirering the next genration of scientists.
Signe Lolle retweeted
A quick and easy reading of our latest work, written by @PabloLaborda95 and illustrated by Elena Contel Maza.
Behind the paper: "Mutations in the efflux pump regulator MexZ shift tissue colonization by P. aeruginosa to a state of antibiotic tolerance".
communities.springernature.c…
Signe Lolle retweeted
Take a look at the @NatureComms 'Behind the Paper' post of our manuscript! And check out its amazing heading illustration made by Elena (@ helen.mushu.science on Instagram) 🦠🧫
communities.springernature.c…
The final version of our manuscript is out in @NatureComms!🤩 Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance @besaraornottobe @LolleSigne @Rigshospitalet @DTUBiosustain 🧵👇nature.com/articles/s41467-0…
So happy to see this one out! My first baby Nature! Huge shout out to @PabloLaborda95 and the rest of the team!
The final version of our manuscript is out in @NatureComms!🤩 Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance @besaraornottobe @LolleSigne @Rigshospitalet @DTUBiosustain 🧵👇nature.com/articles/s41467-0…
Congrats to master Mathilde for defending her MSc today! Can't wait to build on her amazing work establishing #dropletcultures! #microbiology #dtubioengineering
Great day sampling sediments - even though not everything went smoothly (having to hammer out our core)...Looking forward to dig into the #microbiome #archaea and finding clues on #eukaryogenesis
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Signe Lolle retweeted
The first work of my postdoc at @Rigshospitalet and @DTUBiosustain is now available as a preprint! 🤩 Here we show that some antibiotic resistance mutations have hitherto unknown consequences that transcend conventional antibiotic resistance perspectives during infection
Efflux pump mutations in Pseudomonas aeruginosa cause low-level clinical resistance and high-level tolerance to antibiotics in patients biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Very nice MSc defence by Ida Hedal on the use of eDNA to monitor marine biodiversity. Not surprisingly human and swine DNA is over represented in the mammalian cluster....lets stop discharging so much shit in our oceans! #dtuaqua
Signe Lolle retweeted
Excited to have this paper published! Here we looked at single-cell responses to virulent Pseudomonas within a leaf, followed by spatial investigation. Collab with
@colepbio @LolleSigne @KvitkoPhD and heavy lifting by Jie Zhu. cell.com/cell-reports/fullte…
Today our Master student Anne Loch became a Master after defending her work on the metabolic evolution of #Pseudomonasaeruginosa in chronic airway infections in people with #CysticFibrosis! #rigshospitalet #dtubiosustain #infectionmicrobiology
Thanks to @tonecolque for a wonderful talk at #ecfs2023 presenting our work on using #ALIcultures to study longitudinally adapted isolates of #pseudomonas. She has done amazing work on establishing a dual RNAseq platform!
If you want to hear about our work on using #ALIcultures grown by immortalized WT bronchial cells as a proxy for a #CF infection model stop by my poster p36 at #ecfs2023 today.
Signe Lolle retweeted
Our group leader Prof. Helle K. Johansen giving a fantastic talk about the effect of #CFTR #modulators in Denmark hospitals. A really nice study performed by PhD student Maria Bendixen and data analyst Oihane Irazoqui. #ECFS2023 #pathogens #microbiology – at Vienna, Austria
Our amazing PhD student is presenting her work on multi species infections in ALI cultures at #ECFS2023 now! Go see her at poster 241! #pseudomonas #saureus #cysticfibrosis #infectionmicrobiology
Very nice talk from @MBottery about interspecies relations and their impact on antimicrobial susceptibility. A good start to #ECFS2023!