Oncologist @DukeU; interested in cancer research, clinical trials, immunotherapy but many other things - Views are my own
Planet Earth
Joined May 2019
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Mustafa Khasraw (find me in BlueSky) retweeted
Wrapping up marathon of 2025 scientific meetings with a great SNO meeting in Hawaii. Presented latest #ctDNA developments in liquid biopsy space. Moderated an outstanding CNS #metastases oral session. Too little site seeing. Looking forward to opening new trials @PennStNeurosurg. Emerging trans-atlantic collaborations! @AsgeirJakola @DuerinckJohnny @cnsmender @mjlimfat @jasia_mahdi @GeurtsMarjolei @MansouriSheila @Kate_chain @MKhasraw @galldiks @NeuroOnc @PennStNeurosurg @BrainTumorDoc
Mustafa Khasraw (find me in BlueSky) retweeted
Biology by Biorender, say hello to Biology by Banana.
Mustafa Khasraw (find me in BlueSky) retweeted
I would strongly advise every American leader and policymaker to listen carefully to @davidrliu - the most important scientist and innovator of our lifetime and the person who invented both Base editing & Prime editing - the 2 top leading modalities of Gene editing, when he describes in @60Minutes the grave danger which the American BioTech ecosystem is facing due to insufficient federal funding. America is already losing its technological and innovative edge! $BEAM $PRME
Tonight’s episode of @60Minutes will include a segment on the impact of federally funded science and recent cuts to science funding. Our lab’s development of base editing and prime editing and their clinical applications will be among the work described in the episode. paramountpressexpress.com/cb…
Mustafa Khasraw (find me in BlueSky) retweeted
Behind the scenes: Chelsea Railton, Kelly M. Hotchkiss and Kirit Singh @KiritSingh in the lab!
Mustafa Khasraw (find me in BlueSky) retweeted
In glioma, T cell immunotherapies are limited by the quantity of available T cells.
@KiritSingh @PeterFecci @MKhasraw & team address this challenge in preclinical models by peripheral injection of autologous T cells after pre-treatment with IL-7.
Full report jci.org/articles/view/181471
Mustafa Khasraw (find me in BlueSky) retweeted
Primary results of RELATIVITY-098 showing that adjuvant nivo+rela does not improve RFS over nivo alone, HR 1.01, biomarker data pointing to value of presence of tumor as a potential requirement for LAG3 blockade to improve efficacy. Neoadjuvant Nivo/rela had >60% MPR
Mustafa Khasraw (find me in BlueSky) retweeted
Congrats @StephenBagleyMD @DrORourke2 and colleagues @PennCancer on their manuscript in @NatureMedicine showing safety and early efficacy of bivalent CAR T cells in 18 patients with recurrent #glioblastoma!
nature.com/articles/s41591-0…
Mustafa Khasraw (find me in BlueSky) retweeted
Honored to be recognized as the Pennsylvania Medical Society Top 40 under 40. Grateful for my patients, colleagues and mentors who inspire me daily to keep pushing for better answers.
@SSMahaseMD
@PennStNeurosurg
@PennStateGME
#Cancer
bit.ly/43tLTZw
JCI - IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models jci.org/articles/view/181471 @KiritSingh
A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion biorxiv.org/content/10.1101/…
Mustafa Khasraw (find me in BlueSky) retweeted
It's a huge honor to be a part of this truly remarkable set of speakers at the Stand Up for Science rally tomorrow in DC in front of the Lincoln Memorial! (My first speech at this kind of an event!)
Mustafa Khasraw (find me in BlueSky) retweeted
Check out our latest article in Neuro-Oncology, wherein we outline challenges, lessons learned, and even resources (including protocols) for anyone interested in liquid biopsy studies.
"Hitchhiker’s Guide Toward CSF Biomarkers for Neuro-Oncology" @JeffreyZuccato @MKhasraw @gelarehzadeh @IanParneyMDPhD @MayoClinic @PennStNeurosurg @NeuroOnc academic.oup.com/neuro-oncol…
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding: Cancer Cell cell.com/cancer-cell/fulltex…
Very proud of you @zz_zhaozhang
Mustafa Khasraw (find me in BlueSky) retweeted
Honored & humbled
We are proud to announce our 4th DSA recipient of 2024, Zhao Zhang, Ph.D. from @Duke_PCB! His project is titled 'Targeting Genomic Parasites for Glioblastoma Immunotherapy.'
#TheSontagFoundation #DSA2024 #DSAGrantee @zz_zhaozhang
Mustafa Khasraw (find me in BlueSky) retweeted
Anonymous donor gives $50 million to Duke for a proton beam therapy center #protonbeamtherapy
neurosurgery.duke.edu/news/a…
Mustafa Khasraw (find me in BlueSky) retweeted
Delighted to share our comprehensive review on leptomeningeal disease now online @NatRevClinOncol
Items covered:
1. Distinct pathogenesis of LMD and how it varies from parenchymal brain metastases
2. How cancer cells metabolically in the CSF and evade immune cells
3. Latest advances (and gaps) in our diagnostic approach
4. Up and coming clinical trials for diagnostics and therapeutics
5. How we can learn from past failed studies to put forth standardized approaches
And much more!
Huge effort by first author and future neurosurgical start @NeuroAhmad
Many thanks to all team members: @debaratibhanja @SahgalArjun @MKhasraw @VivekSubbiah @BettegowdaMDPHD @UMDNsgyChair @BrainTumorDoc
@NeuroOnc @EANSonline50 @NBTStweets @theABTA @BTNcares @WeTrialshub @NSTumorSection
go.nature.com/3VpH543
Mustafa Khasraw (find me in BlueSky) retweeted
🚨🥁🥁🥁 Hot off the press! @NatRevClinOncol
🚨 Leptomeningeal Metastatic Disease: New Frontiers and Future Directions - Discover groundbreaking insights into LMD in our latest review.
✅From novel diagnostics to cutting-edge therapies like intrathecal and immunotherapies, we explore the path forward in tackling this challenging condition. ✅With advances in mechanistic science and trial design, there's hope on the horizon for improving patient outcomes. 🌟 #LMDResearch #CancerResearch #NeuroOncology #HopeForPatients #precisiononcology #precisionmedicine
Kudos to @NeuroAhmad @DrAMansouri @BrainTumorDoc for spearheading this work!!!
Many thanks to all co-authors:
@debaratibhanja
@SahgalArjun
@MKhasraw
@VivekSubbiah
@BettegowdaMDPHD
@UMDNsgyChair
@NeuroOnc
@EANSonline50
@NBTStweets
@theABTA
@BTNcares
@WeTrialshub
@NSTumorSection Link:
go.nature.com/3VpH543
Delighted to share our comprehensive review on leptomeningeal disease now online @NatRevClinOncol
Items covered:
1. Distinct pathogenesis of LMD and how it varies from parenchymal brain metastases
2. How cancer cells metabolically in the CSF and evade immune cells
3. Latest advances (and gaps) in our diagnostic approach
4. Up and coming clinical trials for diagnostics and therapeutics
5. How we can learn from past failed studies to put forth standardized approaches
And much more!
Huge effort by first author and future neurosurgical start @NeuroAhmad
Many thanks to all team members: @debaratibhanja @SahgalArjun @MKhasraw @VivekSubbiah @BettegowdaMDPHD @UMDNsgyChair @BrainTumorDoc
@NeuroOnc @EANSonline50 @NBTStweets @theABTA @BTNcares @WeTrialshub @NSTumorSection
go.nature.com/3VpH543