Australia’s first Microbiome Research Centre | UNSW | @UNSWMedicine | @SEastSydHealth | CRICOS Provider Code 00098G
Sydney, New South Wales
Joined June 2018
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Microbiome Research Centre retweeted
Weekend read: Veillonella promotes CDI in Crohn’s disease
Oral commensal Veillonella promotes C. difficile germination by disrupting bile acid recycling. Veillonella LPS activates signaling to suppress BA transporter, preventing bile acid reabsorption
cell.com/cell-host-microbe/f…
Microbiome Research Centre retweeted
RESEARCH | J Chen, B Huang et al. (Peking Union Medical College)
ROS-mediated sulfenylation of p-GSK-3β can terminate glycogenesis and initiate gluconeogenesis, leading to hepatic insulin resistance.
dlvr.it/TT735m
Microbiome Research Centre retweeted
GLP-1 medications might increase testosterone levels and help to improve the quality of sperm in men with obesity
go.nature.com/4vfLmXL
Microbiome Research Centre retweeted
Liu et al. present “KRAS mutation-driven O-GlcNAcylation of CLDN18.2 enhances the progression of pancreatic cancer and reduces the efficacy of CLDN18.2-targeted therapy” via
bit.ly/3Rgw4TF
Why do targeted therapies fail in pancreatic cancer? This study identifies a KRAS-driven molecular mechanism that alters CLDN18.2 biology and reduces therapeutic efficacy. The work provides valuable insight into resistance pathways and may guide future precision treatment approaches.
#PancreaticCancer
Microbiome Research Centre retweeted
There are 19 types of cancer associated with obesity. But only a limited number have a very strong association. Two excellent review papers today @NatMetabolism
nature.com/articles/s42255-0…
nature.com/articles/s42255-0…
Microbiome Research Centre retweeted
Watch the latest #GUTVideo on the paper by Prasad et al. “Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach” which investigates how disruptions in gut health contribute to diabetic retinopathy (DR), a major complication of type 2 diabetes.
Watch the #GUTVideo here: bit.ly/3RMXCQA
Read the paper here: bit.ly/4nyhRO5
Researchers focused on tryptophan metabolism and the microbial metabolite indole-3-propionic acid (IPA), which has anti-inflammatory and barrier-protective effects. Using diabetic mouse models, they showed that restoring tryptophan absorption through engineered probiotics, tryptophan-containing dipeptides, or direct IPA supplementation improved gut barrier integrity, reduced inflammation, enhanced glucose regulation, and prevented retinal damage. Human participants with DR had significantly lower IPA levels and higher markers of gut permeability and toxic metabolites compared with diabetics without DR and healthy controls. The study suggests that impaired gut–retina communication plays a key role in DR progression. Overall, IPA emerged as both a potential biomarker for detecting diabetic retinopathy and a promising therapeutic target for preventing or slowing retinal damage in diabetes.
#DiabeticRetinopathy
Microbiome Research Centre retweeted
Oops! when your name unexpectedly appears in parliament.
@MRC_microbiome @emadelomar
michellefitzmaurice.com/when…
Microbiome Research Centre retweeted
🌟🌟🌟 Methodology Highlight
🔗bit.ly/3QC0xLS
This review highlights why biologically informed variant selection is key to credible MR, with practical examples from CRP, alcohol, vitamin D, estradiol, and caffeine. #MendelianRandomization #CausalInference #GeneticEpidemiology
🧬 Better instruments. Stronger causal inference.
@Gut_BMJ @BMJ_Open @FrontGastro_BMJ @BMJOpen_Gastro
Microbiome Research Centre retweeted
🎬 Volume 4, Issue 1
📷 Watch the full issue video and explore recent research in digestive diseases. #Hepatology #Gastroenterology #LiverDisease #TranslationalMedicine #MedicalResearch
🔗 bit.ly/4eje8ky
🔗 bit.ly/3O2p0Zv
🔗 bit.ly/4rSbIwA
🔗 bit.ly/48n3V2S
🔗 bit.ly/4syFbwT
🔗 bit.ly/4edh8Pw
🔗 bit.ly/3NXruIO
🔗 bit.ly/4edh8Pw
🔗 bit.ly/40Omx7X
@Gut_BMJ @BMJ_Open @FrontGastro_BMJ @BMJOpen_Gastro
Microbiome Research Centre retweeted
Interleukin-17 (IL-17 and its receptor, IL7R) is emerging as a key mediator in many immune-related diseases. Today @SciImmunology a superb review
science.org/doi/10.1126/scii…
Microbiome Research Centre retweeted
What if we could predict cancer 5+ years ahead and prevent it? A new landmark study shows the way
Microbiome Research Centre retweeted
Obesity doesn't just affect the waistline—it reshapes the brain. Emerging evidence suggests chronic metabolic overload disrupts neurovascular coupling, blood–brain barrier integrity, cerebrospinal fluid dynamics, and myelination, creating conditions that may accelerate neurodegeneration. As obesity and neurological disorders rise in parallel, understanding these interconnected pathways could reveal new strategies to protect brain health across the lifespan. #Neuroscience #Obesity #BrainHealth
nature.com/articles/s42255-0…
Microbiome Research Centre retweeted
🚀 Volume 4, Issue 1 of #eGastroenterology
✨ eGastroenterology: a new chapter with exciting times ahead!
✨ PMID: 41948152
✨ bit.ly/4eje8ky
📚 Reduced fibre-fermenting capacity of gut microbes in multiple sclerosis may result in prebiotic dietary fibre β-fructan promoting inflammation and CNS damage
📚 PMID: 41585377
📚 bit.ly/3O2p0Zv
🌟 Amyloidogenic phenotypical variation affects post-transplant outcome of hereditary transthyretin amyloidosis: a retrospective study
🌟 PMID: 41659301
🌟 bit.ly/4rSbIwA
💡 High-dose taurine supplementation exacerbates alcohol-associated liver disease by inducing gut microbiota dysbiosis and bile acid dysregulation in mice
💡 PMID: 41809269
💡 bit.ly/48n3V2S
💉 Exercise and dietary interventions ameliorate MASLD via the hepatic PPARγ-miR-802-Psmd2 axis
💉 PMID: 41789415
💉 bit.ly/4syFbwT
🔍 Long-term and short-term outcomes of curative-intent resection for elderly and younger patients with gallbladder carcinoma: a multicentre propensity score-matched cohort study
🔍 PMID: 41948151
🔍 bit.ly/4edh8Pw
🗺️ Burden of metabolic dysfunction-associated steatotic liver disease in the Asia-Pacific region from 1990 to 2023
🗺️ PMID: 41948150
🗺️ bit.ly/3NXruIO
🧬 Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection
🧬 PMID: 41948149
🧬 bit.ly/4edh8Pw
🔬 Massive hepatic necrosis-associated acute liver failure
🔬 PMID: 41561114
🔬 bit.ly/40Omx7X
🚀 @Gut_BMJ @FrontGastro_BMJ @BMJ_Open @BMJOpen_Gastro
Microbiome Research Centre retweeted
BTW This study was on the front page @ntyimes today
A very impressive study for how we could prevent lung cancer more than 5 years before it is diagnosed. Using machine learning, discovery of a 14-plasma protein signature of risk that predicts responsiveness to an antibody therapy to interleukin, IL-1β
Validated across 8 cohorts
@CellCellPress @CharlesSwanton
cell.com/cell/fulltext/S0092…
Microbiome Research Centre retweeted
A very impressive study for how we could prevent lung cancer more than 5 years before it is diagnosed. Using machine learning, discovery of a 14-plasma protein signature of risk that predicts responsiveness to an antibody therapy to interleukin, IL-1β
Validated across 8 cohorts
@CellCellPress @CharlesSwanton
cell.com/cell/fulltext/S0092…
Microbiome Research Centre retweeted
If helpful to understand the importance of this study, I made an infographic with @NotebookLM
Microbiome Research Centre retweeted
Liu et al. present “KRAS mutation-driven O-GlcNAcylation of CLDN18.2 enhances the progression of pancreatic cancer and reduces the efficacy of CLDN18.2-targeted therapy” via
bit.ly/3Rgw4TF
Why do targeted therapies fail in pancreatic cancer? This study identifies a KRAS-driven molecular mechanism that alters CLDN18.2 biology and reduces therapeutic efficacy. The work provides valuable insight into resistance pathways and may guide future precision treatment approaches.
#PancreaticCancer
Microbiome Research Centre retweeted
⭐ Original research in #eGastroenterology
🌏 MASLD is rising across the Asia-Pacific, with marked regional disparities and incidence peaking at ages 20–24.
📈 This GBD 2023 analysis calls for region-specific prevention, early detection and metabolic risk control. #MASLD #LiverHealth
🔓 Read it more: bit.ly/3NXruIO
@Gut_BMJ @BMJ_Open @BMJOpen_Gastro @FrontGastro_BMJ
Microbiome Research Centre retweeted
Last week saw the end of my stay in Melbourne 🇦🇺
3 months has flown by with visits to Adelaide, Newcastle & Sydney
Unforgettable memories, new (and old) friendships, and more research collaborations than I can count! The only low point was Delta coming 4th!
Thank you everyone!
Microbiome Research Centre retweeted
Watch the latest #GUTVideo on the paper by Prasad et al. “Indole-3-propionic acid links gut dysfunction to diabetic retinopathy: a biomarker and novel therapeutic approach” which investigates how disruptions in gut health contribute to diabetic retinopathy (DR), a major complication of type 2 diabetes.
Watch the #GUTVideo here: bit.ly/3RMXCQA
Read the paper here: bit.ly/4nyhRO5
Researchers focused on tryptophan metabolism and the microbial metabolite indole-3-propionic acid (IPA), which has anti-inflammatory and barrier-protective effects. Using diabetic mouse models, they showed that restoring tryptophan absorption through engineered probiotics, tryptophan-containing dipeptides, or direct IPA supplementation improved gut barrier integrity, reduced inflammation, enhanced glucose regulation, and prevented retinal damage. Human participants with DR had significantly lower IPA levels and higher markers of gut permeability and toxic metabolites compared with diabetics without DR and healthy controls. The study suggests that impaired gut–retina communication plays a key role in DR progression. Overall, IPA emerged as both a potential biomarker for detecting diabetic retinopathy and a promising therapeutic target for preventing or slowing retinal damage in diabetes.
#DiabeticRetinopathy
