Tenure Track Fellow (Group Leader) at @LivUniISMIB. Studying cancer metabolism, mitochondria, metabolite signalling. Views are my own.
Liverpool
Joined October 2023
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Marco Sciacovelli retweeted
📢 Last three weeks of #immunometabolism discoveries @Bims_BiomedNews @mitoworld_org ⬇️⬇️⬇️
biomed.news/bims-imicid/2026…
biomed.news/bims-imicid/2026…
biomed.news/bims-imicid/2026…
A large collection of interesting findings across the immune cell landscape!
Highlights in comments 👇
Marco Sciacovelli retweeted
Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis
jci.org/articles/view/200755…
Marco Sciacovelli retweeted
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️
biomed.news/bims-imicid/2026…
Interesting finding:
Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke
Marco Sciacovelli retweeted
RESEARCH | Yao, Shao, Shan, Wu et al. (Zhejiang U)
A distinct lipid-laden subset of monocyte-derived macrophages regulates hepatocyte proliferation and liver regeneration in injured livers, via CD36-mediated signalling.
dlvr.it/TSGY0Y
Marco Sciacovelli retweeted
Often forgotten but essential: long-chain acyl-CoAs in metabolic control dlvr.it/TRkLZL
Marco Sciacovelli retweeted
📢 Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️
biomed.news/bims-imicid/2026…
Interesting finding:
Macrophage anti-bacterial activity is controlled by adenylate kinase 4–mediated mitochondrial DNA synthesis
Marco Sciacovelli retweeted
Happy Sunday! Here are the most recent issues of bims-metlip, chock-full of new analytical and computational methods for #metabolomics and #lipidomics
biomed.news/bims-metlip/2026…
biomed.news/bims-metlip/2026…
Brought to you in collaboration with @Bims_BiomedNews
Marco Sciacovelli retweeted
#NatMetabPicks | In @Nature led by RK Jain, @geochurch & @mvh_lab (@Harvard)
This work highlights the complexity of metabolic dependencies in metastatic site selection.
nature.com/articles/s41586-0…
Marco Sciacovelli retweeted
An update to the Hallmarks of Cancer framework for understanding (and researching) what causes human cancers. spkl.io/6010Aqwbi
Douglas Hanahan
@CellCellPress
ALT Figure 2 The dimensions of cancer\nCREDIT Hanahan - Cell.
Marco Sciacovelli retweeted
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️
biomed.news/bims-imicid/2026…
Interesting finding:
Spatiotemporal regulation of energetic charge dictates T cell function @NatureComms
Marco Sciacovelli retweeted
For nearly a century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @NatMetabolism, led by @thebioKIMist! Leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q 🧵
Marco Sciacovelli retweeted
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️
biomed.news/bims-imicid/2026…
Interesting finding:
Albumin orchestrates a natural host defence mechanism against mucormycosis
Marco Sciacovelli retweeted
🆕Paper in @NatureGenet from Georgios Kanellos in @owen_sansom's lab: Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation nature.com/articles/s41588-0…
Marco Sciacovelli retweeted
Now online: The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer doi.org/10.1158/2159-8290.CD…
Marco Sciacovelli retweeted
Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria dlvr.it/TPlKxf
Marco Sciacovelli retweeted
RESEARCH | F Kaluba, EC Lien et al. (@VAInstitute):
Cancer cells can reroute ketones to produce cytosolic acetyl-CoA and support tumour growth.
nature.com/articles/s42255-0…
Marco Sciacovelli retweeted
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️
biomed.news/bims-imicid/2025…
Interesting finding:
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation
Marco Sciacovelli retweeted
📢Last weeks #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️
biomed.news/bims-imicid/2025…
A huge collection inside!
Interesting finding:
Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity
Marco Sciacovelli retweeted
📢Last 2 weeks of #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️
biomed.news/bims-imicid/2025…
biomed.news/bims-imicid/2025…
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
Great work from Suzan Ber and Alessandro Esposito regarding the metabolic reprogramming driven by different KRAS mutation in colorectal cancer. Thank you for involving me in this cool project! embopress.org/doi/full/10.10…