In this review, Marie Arsenian Henriksson and colleagues discuss the potential of mitochondria as a target for precision medicine in cancer, presenting current inhibitors and challenges, and highlighting those enzymes that are attractive targets. #MTCPubs
nature.com/articles/s41418-0…
Marie Arsenian-Henriksson and colleagues show that a combination therapy that activates three nuclear hormone receptors (GR, ERα and RARα) leads to neural differentiation, metabolic reprogramming and reduced tumour burden in neuroblastoma #MTCPubs
jeccr.biomedcentral.com/arti…
New roles of noncoding RNAs in cancer cells are uncovered. Here, @ClaudiaKutter and colleagues show that LINC00326 interacts with a noncanonical #RBP to impair liver cancer cell growth by altering lipid metabolism. #MTCPubs
gut.bmj.com/content/71/10/20…
Balanced anticodons-codon pools control translation. At the single cell level, @ClaudiaKutter and colleagues found that most cell types exhibit even anticodon-codon pools but increased translation efficiency in neurons. #MTCPubs
genome.cshlp.org/content/32/…
Ute Römling and colleagues show that a single amino acid substitution Q329R in the patatin-like phospholipase CapV leads to functional plasticity, which consequently transforms cell morphology and bacterial physiology #MTCPubs
nature.com/articles/s41522-0…
Paper alert - Maria Johansson and colleagues show that mouse NK cell inhibitory receptor repertoire skewing is observed already in bone marrow and propose a model for how repertoire skewing is established. #MTCPubs
journals.aai.org/jimmunol/ar…
Manuel Patarroyo and colleagues demonstrate a role for laminin alpha 5 in mammary gland remodelling. @MTC_KI #MTCPubs
journals-biologists-com.prox…
Maria Ruiz Perez and colleagues show that neuroblastoma, which originates from embryonic precursor cells, undergoes neural differentiation upon inhibition of fatty acid synthesis, a metabolic pathway frequently activated in human cancer. @MTC_KI #MTCPubs
cell.com/iscience/fulltext/S…
Long noncoding RNAs remodel molecular responses. Here, @ClaudiaKutter and colleagues found that the oncogenic LINC01268 promotes liver cancer via MAPK/NFkB signalling. #MTCPubs @MTC_KI
dovepress.com/high-expressio…
Anders Björkman and Ulrika Morris provide an explanation for intriguing recent findings of frequent asymptomatic P falciparum malaria infections in areas with low herd immunity @MTC_KI #MTCPubs
cell.com/trends/parasitology…
Mobile elements constantly remodel genomes. Here, @ClaudiaKutter et al. show that transposons give rise of new tRNA genes to improve translation efficiency. #MTCPubs @MTC_KI
academic.oup.com/gbe/article…
academic.oup.com/gbe/article…
Galina Selivanova and colleagues publish that p53 activation can boost the immune response to cancers!
@MTC_KI #MTCPubs
cancerdiscovery.aacrjournals…
@MTC_KI retweeted
Our work on ”Regulatory RNA and its association to invasive meningococcal diseases” is now out in @LancetMicrobe . 😊Our SEM picture is the cover picture too. Very proud of the group! @JensKarlsson11 @strategiskaSSF @KAWstiftelsen @karolinskainst @MTC_KI thelancet.com/journals/lanmi…
Yihai Cao and colleagues use zebrafish to visualise how human cancers are killed! #MTCPubs
pnas.org/content/117/37/2291…
Yihai Cao and colleagues demonstrate that concomitant targeting of VEGF and PDGF can inhibit growth of FGF2+ cancers #MTCPubs
nature.com/articles/s41467-0…
Elena Kashuba and colleagues describe that the ribosomal protein S18-2 promotes cell stemness #MTCPubs
pnas.org/content/117/27/1567…
Trouble getting huge plasmids into cells? @ClaudiaKutter and colleagues describe a method which makes this infinitely easier! #MTCPubs
nature.com/articles/s42003-0…
Birgitta Henriques-Normark and colleagues use Grad-Seq to probe RNA-protein interactions in gram-positive bacteria #MTCPubs
embopress.org/doi/full/10.15…