@MachinPhd
Joined November 2018
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Exciting news from our lab! We’ve preprinted that the yeast protein Msc1, known for DNA repair, shifts to nucleus-vacuole junctions (NVJs) during the diauxic shift and prevents toxic NPC aggregation as cells prepare for quiescence. Read it on bioRxiv! 👇 biorxiv.org/content/10.64898…

Msc1 accumulates at and excludes nuclear pore complexes from nucleus-vacuole junctions

Msc1 is a yeast nuclear envelope (NE) protein that facilitates DNA double-strand break repair. In its absence, cells exhibit abnormal nuclear morphologies and maldistribution of nuclear pore comple...

biorxiv.org
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🦠¿Cómo se defienden nuestras células para evitar la aparición del cáncer? El grupo "Inestabilidad Genética y Cáncer", liderado por el Dr. Félix Machín, investiga los mecanismos de la división celular y cómo se reparan las roturas en las cadenas de ADN. @ULL #ITB
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News! Our eLife Version of Record finally published! elifesciences.org/articles/9… Cohesin’s kleisin subunit is back in late mitosis after DNA double-strand breaks, and…

Cohesin reconstitution and homologous recombination repair of DNA double-strand breaks in late...

The cohesin subunit Scc1 returns and reconstitutes the complex with Smc1–Smc3 in late mitosis upon DNA double-strand breaks, although it does not participate in homologous recombination-driven MAT...

elifesciences.org
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👇🏻👇🏻👇🏻
Sanidad Gobcan@SanidadGobCan10 Nov 2025
Replying to @SanidadGobCan
🧩La Unidad, que en 2025 cumple 30 años como Unidad de Investigación Clínico-Experimental, ha contado para esta implementación con la colaboración de la Fundación Bioavance (@FBioavance) ➡️Más info: acortar.link/c6Vp4r
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Félix Machín, PhD retweeted
Felix Prado@Felix_Cabimer29 Jul 2025
Si estás interesado en realizar una tesis doctoral en integridad del genoma, nuestro grupo acaba de recibir un contrato predoctoral (FPI). Ponte en contacto con [email protected] para más información.
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Delighted to announce that our latest paper is finally out in Commun Biol! nature.com/articles/s42003-0…
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Closed mitosis is a form of cell division used by pathogenic fungi and protists. In this process, chromosomes are segregated without dismantling the nuclear envelope (NE). But what happens when they undergo mitosis with an excess of NE? Find out here! onlinelibrary.wiley.com/doi/…

Chromosome Segregation in Closed Mitosis Under an Excess of Nuclear Envelope

This study investigated the impact of Nem1-Spo7/lipin-mediated nuclear envelope (NE) size regulation during closed mitosis in Saccharomyces cerevisiae. Nem1 depletion resulted in persistent chromat...

onlinelibrary.wiley.com
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🚨🚨🗣️📢 Oferta de contrato para la realización de tesis doctoral en el grupo de investigación de nuestro compañero el Dr. Jonay García Luis (@jonaygl) #JoinUs #SomosITB 👇🏻👇🏻
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I am looking for candidates to apply for a Juan de la Cierva postdoctoral fellowship to work on the link between the nuclear envelope and genome instability. Rush, there is only one week left but I’ve got my part ready!
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Estoy buscando candidatos para solicitar una beca postdoctoral Juan de la Cierva para trabajar en la relación entre la envoltura nuclear y la inestabilidad del genoma. ¡Date prisa, solo queda una semana pero ya tengo mi parte preparada!
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I am pleased to share our latest work as a result of collaborating with chemists to delve into SAR and MOA of drug candidates. This time with the small local biopharma company #CEAMED cell.com/heliyon/fulltext/S2…

Fused oxazepine-naphthoquinones as novel cytotoxic agents with diverse modes of action in yeast

The naphthoquinone moiety is commonly found in numerous natural cytotoxic compounds with diverse and pleiotropic modes of action (MOAs). The moiety can exist as a standalone pharmacophore or combined...

cell.com
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Thank you to organisers Aurélia Lewis @lewis_aurelia and María Moriel-Carretero @MorieLAB and everyone who joined us for our 'Roles of Lipids in Nuclear Homeostasis and Genome Stability' Workshop this week. biologists.com/workshops/oct…
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After posting our recent discovery of Msc1 as a protein involved in DNA double-strand break repair in late mitosis, we now post a preprint on how Msc1 might work together with the ESCRT-III complex for this goal: biorxiv.org/content/10.1101/…

Continuous nuclear envelope surveillance is required for DNA double-strand break repair

Precise double-strand break (DSB) repair is paramount for genome stability. Homologous recombination (HR) is preferred to repair DSBs when a nearby sister chromatid ensures an error-free template. In...

biorxiv.org
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Glad to share our latest paper! Msc1 is a nuclear envelope protein that reinforces DNA repair in late mitosis: iScience cell.com/iscience/fulltext/S… ... and stay tuned for more soon!
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Funded places are now available for early-career researchers at our Workshop on 'Roles of Lipids in Nuclear Homeostasis and Genome Stability' organised by Aurélia Lewis @lewis_aurelia & María Moriel-Carretero @MorieLAB. Find out more and apply at bit.ly/493Cwkt
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Félix Machín, PhD retweeted
Miguel G. Blanco Lab@DNA_Repair_USC4 Jan 2024
If you are interested in applying for a Juan de la Cierva 2-year postdoctoral position to work on DNA repair and genome stability at CIMUS, in landmark Santiago de Compostela, get in touch with us before January 20th. All the information at aei.gob.es/convocatorias/bus…
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Félix Machín, PhD retweeted
Uli Rass@uli_rass15 Jan 2024
Please RT & spread the word: The Genome Damage and Stability Centre @GDSC_Sussex is looking to appoint a Lecturer/Senior Lecturer to complement our research into the molecular mechanisms underpinning genome maintenance. Closes 18/03/2024. For details see: jobs.sussex.ac.uk/job/286f3d…
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Félix Machín, PhD retweeted
Cortés Lab@CortesLab4 Dec 2023
📢Permanent position open📢 We offer a permanent contract with a competitive salary for a Senior Research Scientist with high motivation and proven experience in functional genomics. Contact: [email protected] cnio.es/empleo/research-scie… Come join us @CNIOStopCancer
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We are pleased to share with you our latest pre-print on the discovery of Msc1 as a late mitotic DNA repair factor in yeast. biorxiv.org/content/10.1101/…

Msc1 is a nuclear envelope protein that reinforces DNA repair in late mitosis

Precise double-strand break (DSB) repair is paramount for genome stability. Homologous recombination (HR) repairs DSBs when cyclin-dependent kinase (CDK) activity is high, which correlates with the...

biorxiv.org
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