Junior group leader @ECAS; fascinated to study the role of vascular cells beyond angiogenesis; loves to travel, meet strangers and explore cultures
Heidelberg, Germany
Joined April 2009
- Tweets232
- Following691
- Followers479
- Likes1.4K
Mahak Singhal retweeted
This Research Letter identifies a long sought molecular switch in a pathway that regulates both blood vessel growth and inflammation: doi.org/10.1172/JCI204085
Mahak Singhal @Mahak906, Hellmut G. Augustin @HellmutAugustin & team @uniklinik_hd find that ectodomain cleavage of the vascular receptor Tie1 distinguishes the inflammatory from the angiogenic functions of Angiopoietin-Tie signaling, mechanistically uncoupling two fundamental #vascular programs.
Mahak Singhal retweeted
‼️ELS2027 is here‼️
Registration for European Lymphatic Symposium 2027 is now open! 🎉
Join us in beautiful Budapest for cutting-edge science, and networking with the lymphatic research community.
Register today: semmelweispremium.hu/els2027
Tie1 ectodomain cleavage distinguishes its angiogenic from inflammatory functions! Kudos to Miki and Jingjing for their persistence and hard work! Thanks to @HellmutAugustin and all collaborators! @dfg_public @UniHeidelberg @HITAC_MDC!
Out now in JCI: jci.org/articles/view/204085
Mahak Singhal retweeted
Dr. Mahak Singhal and @HeidelbergU collaborators presented a temporal map of organotypic changes in #endothelial proliferation at different stages of mouse life. go.nature.com/4pHHyNf
Comparative analyses of 12 different organs revealed a tissue-specific pattern of age-related changes in endothelial proliferation capacity.
🔓 Read the #OpenAccess study in @Nature_NPJ.
Does aging always reduce the regenerative capacity of blood vessels? #NO!
Proud to share our latest paper characterizing endothelial proliferation across organs, sex, and aging, discovering unexpected tissue-specific patterns of vascular renewal. rdcu.be/fwvQ6
Congratulations to Yifang and Anna for driving this project that answered this fundamental question and provided new insight into organotypic vasculature! #Cardiovascular #Aging
3
76
Delighted to present 🧬 InCURA, a regulation-centric way to analyze omics data by clustering genes based on shared upstream regulatory profile.
Nuc Acids Res article - doi.org/10.1093/nar/gkaf1377
Streamlit app - incura.streamlit.app/
#Bioinformatics #Transcriptomics #SystemsBiology
2
2
105
Congratulations to Lorna Rinck, who spearheaded the project! Many thanks to @JulioSaezRod and his team, especially Ricardo, for their critical feedback and input in developing InCURA from an idea into a user-friendly and regulation-centric method.
2
71
Mahak Singhal retweeted
Proud to share our work in #Cell_Metabolism.
Check out our study on nutrient responsive epigenetic control of vascular repair- a true team effort led by brilliant PhD scientists. Many thanks to the handling editor for the fair and constructive process #HITAC, #SFB1366, #SFB1531
New! Online now: Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation dlvr.it/TP0Dhm
Extremely delighted and humbled by the positive evaluation of our Vascular-Rhythm project. A great shoutout to my research team @ECAS_Mannheim, collaborators, mentors, and dear friends & family! Thank you! #ERCStG @ERC_Research
Mahak Singhal retweeted
Super cool presentations today by @ana_cujba @AliHermanlab, Amber Stratmann and @mahak906! Circadian biology, senescence, cilia and many more new exciting topics in this morning session!
Want to know how to isolate liver endothelial cells without any prior training? Check our latest work in @CommsBiol, describing a high-throughput perfusion-independent method to isolate liver sinusoidal endothelial cells. Blood vessels rock!!! @EVB_Org rdcu.be/d5C82
Closing 2024 with gratitude and joy to see my scientific family growing. Thanks to them and our brilliant collaborators, we did some crazy science in 2024 with our first paper accepted! Can’t wait for 2025! I wish you all a fantastic holiday and great start to 2025! Thank you!
Mahak Singhal retweeted
Just a quick reminder for everyone about our virtual workshop on September 6th, on the pathology of aging:
buff.ly/3yKr3K3
This webinar will explore the mechanisms underlying HSC aging, focusing on mitochondrial dysfunction and on the peri-vascular/stromal niche.
It’s happening and I am by excited to witness @IVBM2024. Looking forward to crazy vascular biology!
Please get in touch if working at a junction of circadian and vascular biology excites you!
New PhD opportunity in the lab of Mahak Singhal, within the European Center of Angioscience in Mannheim, DE. More details available at EVBOs Job Opportunities webpage:
buff.ly/3wanNX4
Beyond excited to present a perfusion-independent method to isolate liver endothelial cells. Thanks to @ResearchLifesci for supporting the project and a shoutout to the liver community @EVB_Org @vascularbiology for rapid high-throughput LSEC isolation. biorxiv.org/content/10.1101/…
Mahak Singhal retweeted
Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9 | Science Translational Medicine science.org/doi/10.1126/scit…
