@MansourLab

Lab for Stem Cells, Brain Generation & Degeneration Research @hujimed @hebrewu. We use human stem cell-based technologies to study neurological disorders

 Jerusalem
mansour-lab.com
Joined February 2021
  • Tweets87
  • Following498
  • Followers438
7Media
We are recruiting students and postdoctoral fellows to explore the molecular and cellular mechanisms that shape neurodevelopment. Our research harnesses the unparalleled genetic power of Drosophila to uncover fundamental principles of neural circuit assembly and remodeling.
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Mansour Lab retweeted
Cell@CellCellPress15 Dec 2025
In the latest issue! Fate and state transitions during human blood vessel organoid development dlvr.it/TPqjMd

Fate and state transitions during human blood vessel organoid development

(Cell 188, 3329–3348.e1–e18; June 12, 2025)

cell.com
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New preprint from the lab! We discovered transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to surface expansion in humans 1/ doi.org/10.1101/2025.10.07.6…
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I'm excited to share our new preprint on LagTag, a method that recovers both past and present chromatin states from the same mammalian cells. biorxiv.org/content/10.1101/…
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A Postdoctoral Research Associate post is available in the lab in Human Organoid Neurobiology and ALS/MND Research - see our job advert in Nature Careers nature.com/naturecareers/job…

Postdoctoral Research Associate - Cambridge, Cambridgeshire

A Postdoctoral Research Associate position is available for 2 years in human 3D organoid-based disease modelling in Amyotrophic Lateral Sclerosis (...

nature.com
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Mansour Lab retweeted
Evgeny Kvon@evgenykvon6 Jan 2025
Our preprint is out nature.com/articles/s41467-0… In a new set of experiments, we screened a panel of rare and common variants from patients with Autism and identified variants in enhancers of OTX2 & Mir9-2 that reproducibly alter their activity in vivo! Huge congrats to @ewholling
Evgeny Kvon@evgenykvon11 Dec 2023
How to test the functional impact of noncoding variants in vivo? Happy to share our work led by @ewholling where we developed dual-enSERT, a new method that enables rapid, quantitative comparison of human enhancer variant activities in live mice. Check this Tweetorial for details
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Excited and relieved to share with you our microglia-sufficient brain organoid work just online @Nature nature.com/articles/s41586-0… IPSC-derived microglia reprogram them metabolically! And make them mature faster!
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I am excited to show you these beautiful movies! A great effort together with @TweetPetrStrnad at @ViventisMicro to design a new #lightsheet for long term high throughput live imaging of large specimens #organoids, #embryoids and entire animals #hydra. dlvr.it/Swnqmw
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Mansour Lab@MansourLab17 Jun 2023
3/ Candidates with prior experience in stem cells, tissue culture, microscopy, and/or next-generation sequencing would be an asset. If you are interested, please send your application and CV to: [email protected]. @ERC_Research funded project!
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iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons #ALS #diseasemodeling cell.com/cell-reports/fullte…

iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem...

Amyotrophic lateral sclerosis causes motor neuron degeneration but leaves most other neurons intact. Held et al. find that familial ALS mutations cause distinct RNA profiles in iPSC-derived motor...

cell.com
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Federico Soria@SoriaFN11 Jul 2023
3D segmentation and analysis of cortical mouse #microglia with 3D ImageJ Suite. The free, open source software by Thomas Boudier is available as an ImageJ/FIJI plugin (mcib3d.frama.io/3d-suite-ima…).
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Thank you, Yanhong Shi & Jonas Cerneckis for this excellent summary of our work! @CellStemCell SPOTLIGHT: hPSC-derived microglia thrive in a humanized brain en... sciencedirect.com/science/ar…
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Ayal Ben-Zvi@AyalBen16 Jun 2023
We are recruiting new lab members (Master, PhD and post-doc candidates) for a very exciting (ERC funded) project, designed to unfold the molecular and cellular properties of Brain Barrier cells that mediates the entry of immune cells into the brain.
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Biologists trying to create laboratory models of the early growth of a human embryo have taken a major step forward. scim.ag/32S

Biologists create detailed lab replicas of early human embryos

Grown from stem cells, mock embryos recapitulate development beyond implantation stage

science.org
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🧐 In case you haven't already, check out this study led by Drs. Fred Gage and Abed Mansour from @salkinstitute! 🧠 Their team developed a neuroimmune #organoid model that offers opportunities to study functional #microglia phenotypes. @CellCellPress | bit.ly/3qbqLYe
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There's one more week left to apply for 2 MRC-funded Research Associate positions in the lab. One post is in Organoid Neurobiology and the other one is in Computational Biology/Data Science with Harvard-Cambridge collaborative opportunities. See below:
Andras Lakatos@LakatosLab18 Apr 2023
Please RT. Postdoctoral Research Associate positions are open in our lab in Cambridge: 1 in Computational Neurobiology; 1 in Human Organoid Neurobiology at the intersection with neurodegeneration research (MND/ALS). Please see: jobs.cam.ac.uk/job/40520/, jobs.cam.ac.uk/job/40536/
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Ahd Diab@AhdDiab118 May 2023
Scientists Celebration Way😝🔥 Congratulations to our boss on getting his article published! well deserved success!! @MansourLab @mansour_abed_A @JEintracht
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IMRIC@IMRIC_HUJ12 May 2023
IMRIC congratulates Assistant Professor Dr. Abed Mansour @mansour_abed_A for his new breakthrough paper on studying new roles of human microglia using brain organoids published in Cell. Congrats Abed and team for an amazing study!! @Hujimed @MedNeuroHUJI cell.com/cell/fulltext/S0092…

An in vivo neuroimmune organoid model to study human microglia phenotypes

Schafer et al. present an organoid-based xenotransplantation platform to study human brain-environment-dependent and disease-associated microglia phenotypes under in vivo conditions.

cell.com
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"Grafted organoids reveal how microglia adapt to shifting brain environments" “What they show is exciting,” Florent Ginhoux says. “But it is really just the beginning.” Thank you @Spectrum for featuring our study. Thanks, @FGinhoux!
Spectrum (Autism Research News)
@Spectrum11 May 2023
.@FGinhoux calls a new approach for exploring the role of microglia in neurodevelopment exciting, "but it is really just the beginning," he says. How do you think this method can benefit the field? Read about the method: bit.ly/3NWPM36 By @avaskham. @AugusteVad
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We are hiring! A post-doc with computational expertise to investigate aging of neural epigenome @DZNE_en , @UniFAU Pls DM &RT. We want to identify epigenetic links between aging and cognitive decline.
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