Research Assistant Professor @NUFeinbergMed @NorthwesternU @Penzes_Lab. Interested in genetics and neurobiology of autism, schizophrenia and epilepsy.
Chicago, IL
Joined November 2019
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- Following436
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Marc Forrest retweeted
Online now: Soluble α2δ-1, altered in disease CSF, modulates network homeostasis and rescues deficits in a neuropsychiatric mouse model dlvr.it/TRb1cx
Congrats to @MarcDosSantos3 for his incredible work on developing a potentially new therapeutic for schizophrenia. Fortunate to have been part of this work.
news.feinberg.northwestern.e…
Marc Forrest retweeted
Congrats to @MarcForrest7 , Ph.D., on receiving a 2025 BBRF Young Investigator Grant for innovative mental health research.
Read more: bbrfoundation.org/content/br…
Marc Forrest retweeted
Akap11 mutations greatly increase risk for #bipolar disorder and #schizophrenia. Not much was known about this gene when we started. Here’s what we learned!
biorxiv.org/content/10.1101/…
Thanks to Morgan Sheng, @ajgrange, Yang Ge, Borislav Dejanovic & crew @broadinstitute
Marc Forrest retweeted
Come see new work from penzes lab members #sfn2024. Saturday afternoon "synapses", poster session B.
Jessica Christiansen on novel regulatory sites in schizophrenia risk gene TRIO - poster B67.
@MarcForrest7 on homeostatic plasticity in 16p11.2 duplication - poster B68.
Marc Forrest retweeted
A Review in @NatRevNeurosci describes our current understanding of the complex genetic architecture of schizophrenia and considers how the genomic findings can be interrogated to boost our understanding of the neurobiology of the disorder. 🔒 go.nature.com/3zZpKY6
Marc Forrest retweeted
Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes dlvr.it/T84fwQ
Marc Forrest retweeted
Northwestern Medicine scientists have been awarded a $17 million grant to study genetic causes of #autism and #schizophrenia, with the aim of developing new drugs to treat the conditions.
spr.ly/6019eLusT
Marc Forrest retweeted
Whole brain(!) in vivo gene editing to correct a point mutation in a ASD mice model.
Li, Zhang, et al. Nat Neuro
nature.com/articles/s41593-0…
Marc Forrest retweeted
Very good to see this very large study countering strong claims that maternal infection increases risk of autism in offspring. They found no evidence of an association.
Findings "strongly imply that there is no specific link between maternal mental illness or maternal infection during pregnancy" & neurodevelopmental disabilities (including autism) in offspring cambridge.org/core/journals/… free
Marc Forrest retweeted
Glad to see the psychiatric genetics researchers introducing the practice of adding polygenic score effect sizes in the MAF vs effect size plot
xitter.cf/doctorveera/status/171…
Genetic risk factors of schizophrenia and their effect sizes--common variants, rare variants, CNVs and polygenic risk.
I love the addition of the effect size of the top 1% of polygenic risk to the plot. It highlights the importance of cumulative risk of common variants and reminds us that polygenic risk can be equivalent to monogenic risk factors.
From a recent review article by the experts in schizophrenia genetics (Owen, O'Donovan et al. Mol Psych)
nature.com/articles/s41380-0…
Marc Forrest retweeted
Nice plot visualizing the effect sizes (vs carrier frequency) of common variants, rare variants, CNVs and polygenic score (top vs bottom decile) associated with ADHD.
From a new Nat Rev Dis Primer on ADHD by Faraone et al.
nature.com/articles/s41572-0…
Essay from a medical student suffering from bipolar disorder: "It left me wondering if society has the wrong idea [...] Yes, it may enhance aspects of creativity and productivity at times, but that does not detract from the struggle of living with a chronic illness."
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Marc Forrest retweeted
The first cellular map of a mammalian brain is here. 🧠✨
Over 6 years and 32 million cells in the making, the complete adult mouse brain cell-type atlas reveals astonishing diversity and regional specificity.
Dive deeper: alleninstitute.org/scientist…
@nature #studyBRAIN #BICCN
New Center for Psychiatric Neuroscience being created at @NUFeinbergMed. Even got mentioned in the new release! 😁
We're diving into mysteries of the mind. 🧠
Our newly launched Center for #PsychiatricNeuroscience is breaking down barriers and uniting scientists across disciplines to unravel the complexities of #MentalHealth.
spr.ly/6011RparL
Marc Forrest retweeted
An NIH advisory group announced today that they're recommending the agency boost its minimum #postdoc salary to $70,000, up from the current $56,484. Many postdocs feel "underpaid and overworked," a co-chair said.
My latest for @ScienceInsider:
science.org/content/article/…
Marc Forrest retweeted
A new review summarizing my current thoughts on the neurobiology of schizophrenia: authors.elsevier.com/a/1iF29…
Marc Forrest retweeted
Just a reminder that Cellpose2.0 is a great, free, fast option to quant all kinds of histology from immediate early genes to RNAscope etc.
Counted cFos for n=12 mice across n=19 brain regions, totaling over 20k cells in ~2hrs
github.com/mouseland/cellpos…
This is ah ma zing .. first attempt, in less than 1-min from my phone I copied a low-res multi-channel image of DRG from our lab website, uploaded to cellpose.org, selected red channel and boom ... 🤯
Marc Forrest retweeted
AI reviewing GWAS literature. Looks pretty cool. May be its time for me to retire. 😅
youtube.com/watch?v=sPiOP_CB…