@MarcusHarrell12

PhD Candidate in @daslab_pombe lab at Boston College

 Chestnut Hill, MA
Joined September 2018
  • Tweets82
  • Following87
  • Followers72
13Media
Marcus Harrell retweeted
ASAPbio@ASAPbio_27 Nov 2023
Meet your colleagues and discuss a new preprint over lunch during #cellbio2023 🥳 We’re pleased to announce preprint launch parties organized by ASAPbio on Dec 4 & 5 in Boston, MA, USA!
1
9
1
15
6,522
Marcus Harrell retweeted
ASAPbio@ASAPbio_27 Nov 2023
Replying to @ASAPbio_ @TaraEssockBurns @dave_matus @ArcadiaScience
Preprint launch party (Boston) Tue Dec 5, 1-2pm | Marcus Harrell @DasLab_Pombe | The Arp2/3 complex promotes periodic removal of Pak1-mediated negative feedback to facilitate anticorrelated Cdc42 oscillations: buff.ly/3sRpHKy RSVP: buff.ly/40XPflZ #cellbio2023
1
1
1
4
2,432
Our models suggest that there is a phase shift between the accumulation of Cdc42, Scd1, and Scd2 (Positive feedback loop) and Pak1 (time-delayed negative feedback). Indeed, we were able to capture these shifts in vivo. (Colors correspond to protein of interest) (12/17)
1
1
449
more replies
And while much work has established the impact of Cdc42 on membrane trafficking, we are now showing that membrane trafficking, in turn, directly regulates Cdc42 activity. (16/17)
1
1
1
307
To read more about our work, please read our preprint which I have linked here: biorxiv.org/content/10.1101/… (17/end)

The Arp2/3 complex promotes periodic removal of Pak1-mediated negative feedback to facilitate...

The conserved GTPase Cdc42 is a major regulator of polarized growth in most eukaryotes. Cdc42 periodically cycles between active and inactive states at sites of polarized growth. These periodic...

biorxiv.org
2
2
122
Load more