Professor at Cornell exploring signaling networks in genome maintenance and cell cycle control (proteomics, DNA repair and replication)
Joined July 2019
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Excited to share our preprint reporting a completely new approach to study kinase signaling (ProKAS):
"Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling"
We applied it to DDR kinases. Please share.
biorxiv.org/content/10.1101/…
ProKAS is based on a tandem array of peptide sensors with amino acid barcodes that allow multiplexed analysis for spatial, kinetic, and screening applications using mass spectrometry.
This work was led by the amazing graduate student @wjincomstock. Congratulations to Will!
Marcus Smolka retweeted
Not one but TWO faculty searches in our department @CornellMBG
1️⃣ Cell & Mol Biol @weillinstitute
academicjobsonline.org/ajo/j…
2️⃣ Human Genetics/Genomics
academicjobsonline.org/ajo/j…
Outstanding science, supportive community, beautiful environment. We have it all!
Spread the word 🙏
Marcus Smolka retweeted
We're excited to announce a search for a tenure-track Assistant Professor in MBG and @CornellCALS in the area of human genetics and genomics. Please share with interested candidates!
academicjobsonline.org/ajo/j…
Marcus Smolka retweeted
🥳Congratulations to our founding director, Scott Emr, for being awarded the 2024 Louisa Gross Horwitz Prize, along with Wesley Sundquist, for the discovery of the ESCRT pathway! cuimc.columbia.edu/news/2024… @Columbia
Marcus Smolka retweeted
Excited to announce an MBG faculty search for two assistant professor positions in collaboration with the Weill Institute for Cell and Molecular Biology, @weillinstitute.
Please share and apply!
academicjobsonline.org/ajo/j…
Marcus Smolka retweeted
Thrilled to share our latest story @NatureCellBio on a new way to control protein localization without exogenous triggers (e.g., light/rapamycin)—take advantage of endogenous triggers in dividing cells!
Free link: rdcu.be/dSlrS Regular link: nature.com/articles/s41556-0… 1/4
Marcus Smolka retweeted
Part 2 of my postdoc work is out! We show that the ploidy-to-cell size ratio is a highly conserved, “intrinsic” determinant of cell physiology. Check out the paper for more insight into how and why.
Link - nature.com/articles/s41594-0…
Free PDF – rdcu.be/dONo3
Also, a fun🧵!
Marcus Smolka retweeted
I am delighted to announce that I will be starting a new chapter of my career @OhioState @OSUVetCollege @OSUCCC_James as an assistant professor. I will continue my research on #KRAS cancers, and the lab is open to anyone who shares same interest!
Graduate student @BokunXie wins best paper award at the Faseb Recombination meeting!
New preprint. More on non-canonical motifs for DDR kinases.
Here we find that Tel1 (yeast ATM) targets D/E-S/T.
... more prevalent than S/T-Q
... NOT shared with Mec1.
May explain how Tel1 plays specialized roles in DNA repair and telomere maintenance.
biorxiv.org/content/10.1101/…
New paper on non-canonical DNA-PKcs signaling.
We speculate that the substrate recognition pocket of DNA-PKcs can adopt multiple configurations, which would explain how it can phosphorylate S/T-Q as well as S/T-ψ-D/E motifs.
jbc.org/article/S0021-9258%2…
This work was driven by Bokun (@BokunXie) a fantastic graduate student. He is starting to look for a postdoctoral position to start in the Fall. The lab that is able to recruit him will be very lucky!
How does DNA damage signaling suppress chromosomal rearrangements?
Check our recent paper just out in EMBO Journal.
Multi-step control of homologous recombination via Mec1/ATR suppresses chromosomal rearrangements | embopress.org/doi/full/10.10…
Marcus Smolka retweeted
Happy to share the first piece of my PhD work @embojournal .Thanks all authors for help! Thanks my advisor @MarcusSmolka and my collaborators Wolf-Dietrich Heyer.
Multi-step control of homologous recombination via Mec1/ATR suppresses chromosomal rearrangements
embopress.org/journal/146020…
How does DNA damage signaling suppress chromosomal rearrangements?
Check our recent paper just out in EMBO Journal.
Multi-step control of homologous recombination via Mec1/ATR suppresses chromosomal rearrangements | embopress.org/doi/full/10.10…
Marcus Smolka retweeted
I'm thrilled to share our latest study in @NatureComms. We discovered a new mechanism of chemotherapy resistance in BRCA-deficient tumors and a new way to fight it! Thank you all for your contribution!!
nature.com/articles/s41467-0…
Marcus Smolka retweeted
New paper from @DoerrLab in @PLOSGenetics: Genetic interaction mapping reveals functional relationships between peptidoglycan endopeptidases and carboxypeptidases
journals.plos.org/plosgeneti…
