@MatheaGeraud

Academic Clinical Lecturer | Reasearch at CRCT, SIGNATHER team (O. Sordet) | Interested in Transcription-associated DNA damage in cancer & neurodegeneration

 Toulouse, France
crct-inserm.fr/en/transcriptional-dna-breaks-and-human-disease/
Joined June 2021
  • Tweets19
  • Following140
  • Followers53
Glad to share our work in @ScienceAdvances on how targeted cancer therapy promotes the persistence of topoisomerase 1 cleavage complexes, which are involved in the emergence of resistance in lung cancer. Thanks to Olivier Sordet @SIGNATHER and all co-authors.
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Replying to @MatheaGeraud @ScienceAdvances @SIGNATHER
science.org/doi/10.1126/scia…

Persistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targe...

Resistance to targeted cancer therapies often arises from drug-tolerant cells, which survive treatment by entering a nonproliferative state. Over time, these cells can acquire mutations that contri...

science.org
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@GenceRemi @CelDelahaye @AgneseCristini @JulienMazieres @GillesFavrecrct Thanks to our financial supports @IUCTOncopole @Institut_cancer @laliguecancer , to the ARC, FRM and University of Toulouse.
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Check out this #protocol by @MatheaGeraud @AgneseCristini @LaraFernandezMz @AndreaCAjello @SIGNATHER et al for single-cell analysis of DNA double-strand break production and repair in cell-cycle phases by automated high-content microscopy: star-protocols.cell.com/prot…. 🔬🧬Research in Cell Reports: doi.org/10.1016/j.celrep.202…
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embopress.org/doi/full/10.10… Excited to share our latest publication in EMBO Journal on TDP1 phosphorylation at S61 in mitosis and genome instability and Cancer. Congratulations Srijita!! for her incredible PhD work. @IndiaDST @serbonline @DBTIndia @ICMRDELHI @iacskolkata
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Mathéa Geraud retweeted
Cell Reports@CellReports17 May 2024
TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks dlvr.it/T71zmm

TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA...

Geraud et al. generate human SCAN1 cells by CRISPR-Cas9 to study SCAN1 disease. SCAN1 cells accumulate transcriptional DSBs specifically in G1 phase due to enhanced DSB formation and defective...

cell.com
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Happy to share our work in @CellReports suggesting a role for transcriptional DSBs in SCAN1 neurodegenerative disease. SordetLab @SIGNATHER @crctoncopole Thanks to @AgneseCristini @BeryNicolas @gcapranico lab and all the authors! cell.com/cell-reports/fullte…

TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA...

Geraud et al. generate human SCAN1 cells by CRISPR-Cas9 to study SCAN1 disease. SCAN1 cells accumulate transcriptional DSBs specifically in G1 phase due to enhanced DSB formation and defective...

cell.com
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We show that SCAN1 cells accumulate transcriptional DSB, specifically in G1-phase cells. Mutated TDP1 both increases transcriptional DSB production and hampers DSB repair by TDP2 compensatory pathway.
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Mathéa Geraud retweeted
CRCT-Oncopole@crctoncopole8 Jun 2023
Le @crctoncopole recrute un(e) Ingénieur(e) en #Bioinformatique. CDD 24 mois temps plein Prise de fonction à partir du 01 septembre 2023 Consulter l'annonce ➡️crct-inserm.fr/recrutement/
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Sunny all-day retreat of the @SIGNATHER @crctoncopole team in Toulouse countryside. Exciting projects regarding biomarkers, liquid biopsies, transcription R-loops, Double-strand breaks, resistance to targeted therapies and translational research. Great team to defeat #LungCancer
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Mathéa Geraud retweeted
CRCT-Oncopole@crctoncopole9 Jan 2023
#ConferenceduCRCT | Vendredi 13 janvier à 11h00 Le Dr Sarah Lambert de l'@institut_curie interviendra au CRCT sur : "Building a barrier to replication fork degradation with Okazaki fragment". #Cancer Plus d'infos 👉bit.ly/3QroiSq
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Mathéa Geraud retweeted
CRCT-Oncopole@crctoncopole8 Jul 2022
L'association @AlkRos1France fait un don de 5000 euros à la recherche à l'équipe SIGNATHER du @crctoncopole de Toulouse. crct-inserm.fr/un-don-pour-l…
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Very happy to share our work investigating the role of RNase H2 in maintaining R-loop balance and preventing DNA breaks in human cells @NatureComms! Thanks to GromakLab @Dunn_School and all co-authors @Michael_Tellier @BeryNicolas and the others nature.com/articles/s41467-0…

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA...

Nature Communications - RnaseH2 is mutated in severe neuro-inflammatory disorder Aicardi‐Goutières syndrome. Here the authors reveal that RNase H2 controls cellular R-loop homeostasis to...

nature.com
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Mathéa Geraud retweeted
Nicolas Bery@BeryNicolas11 Oct 2021
Glad that our review on "Targeting small GTPases and their downstream pathways with intracellular macromolecule binders to define alternative therapeutic strategies in cancer" is now out @PPPublishing. Written with @MarieSorbara. @crctoncopole @BiochemSoc portlandpress.com/biochemsoc…
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DNA ligase III loss induces MRE11-mediated ssDNA gaps and PARPi sensitivity in BRCA1−/−53BP1−/− cells @MolecularCell cell.com/molecular-cell/full…
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Interested in applying CRISPR screening technologies to discover new DNA repair genes and functions? In our latest review written by Sam Hayward we discuss the use of CRISPR screens for the study of homologous recombination! @ELS_Genetics authors.elsevier.com/a/1dor2…
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Mathéa Geraud retweeted
🔬 R-loop@R_loop_papers11 Sep 2021
Transcription-associated DNA breaks and cancer: A matter of DNA topology dlvr.it/S7N5TD

Transcription-associated DNA breaks and cancer: A matter of DNA topology - PubMed

Transcription is an essential cellular process but also a major threat to genome integrity. Transcription-associated DNA breaks are particularly detrimental as their defective repair can induce gene...

pubmed.ncbi.nlm.nih.gov
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Glad to see our review published @IRCellMolecBio, summarizing the role of DNA topology on transcriptional DNA breaks in cancer. sciencedirect.com/science/ar… @AgneseCristini @crctoncopole @ARS_OC @Fondationfrance
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