Axonal mRNA trafficking and local translation | Group leader @FGA_lab | NWO Veni fellow | father of two
Amsterdam, Nederland
Joined July 2015
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Max Koppers retweeted
very cool paper!
FMRP regulates MFF translation to locally direct mitochondrial fission in neurons | Nature Cell Biology nature.com/articles/s41556-0…
Max Koppers retweeted
RNA granules in flux: dynamics to balance physiology and pathology — a Review by Michael A. Kiebler & Karl E. Bauer
go.nature.com/3UCa0Se
Max Koppers retweeted
Check out our preprint using imaging-omics to characterize the #OrganelleSignature - the morphology interactions & distribution of #ER❤️ #Lysosomes🩵 #Mitochondria💚 #Peroxisomes🧡 #Golgi💛 & #LipidDroplets🩷 - of live #neurons and #astrocytes!
doi.org/10.1101/2024.10.30.6…
🧵1/11
Max Koppers retweeted
APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2 instead of H2O2. We use LaccID for EM imaging of cultured cells and fly brains, and for proteomic mapping of the changing surface composition of T cells that engage with tumor cells via antigen-specific T cell receptors.
Max Koppers retweeted
Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!)
O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵
nature.com/articles/s41592-0…
Max Koppers retweeted
Spatiotemporal dynamics and selectivity of mRNA translation during mouse pre-implantation development biorxiv.org/content/10.1101/…
Max Koppers retweeted
Neuromuscular dysfunction in patient-derived FUSR244RR-ALS iPSC model via axonal downregulation of neuromuscular junction proteins biorxiv.org/content/10.1101/…
Max Koppers retweeted
Light-induced targeting enables proteomics on endogenous condensates 🤯
cell.com/cell/fulltext/S0092…
Max Koppers retweeted
IGF2BP1 phosphorylation in the disordered linkers regulates ribonucleoprotein condensate formation and RNA metabolism: nature.com/articles/s41467-0…
Max Koppers retweeted
Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neurons
cell.com/developmental-cell/…
Max Koppers retweeted
Getting ready (rushing) for #SfN24?Us too!😃
Excited about Neuron, Glia, RNA, Plasticity, FXS or Local Translation?Us too!😃
Come join us Tues 8th, with 14 great (&short!) talks on emerging roles of axonal, dendritic, glial proteostasis in health & disease
pls spread the word!
ALT mRNA Regulation and Translation in Plasticity Tues 8th @ 8am - 11:30am MCP Room S404 Speakers: Eurus Wang (Lai lab), City Univ. of Hong Kong Jacque Ip, The Chinese Univ. of Hong Kong Ruth Singer (Darnell lab), The Rockefeller Univ. Dong-Woo Hwang (Singer lab), Albert Einstein Col. of Med. Hovy Wong (Sjöström lab), McGill Univ. Ernesto Griego (Castillo lab), Albert Einstein Col. of Med. Pabitra Sahoo, Rutgers Univ. Newark Ulrich Hengst, Columbia Univ. Jimena Baleriola, Achucarro Bacque Ctr. for Neurosci., Spain Nisha Raj, Emory Univ. Aurore Thomazeau, CNRS, France Jewel Li (Sossin lab), McGill Univ. Haiyan He, Georgetown Univ. Michael Vasek (Dougherty lab), Washington Univ. in St. Louis
Max Koppers retweeted
AXON2025 is gearing up! If you're passionate about neural circuit development, this is the must-attend event of next year — set in an extraordinary, non-conventional location🚢that you won’t want to miss! #AXON2025 @JeroenPasterk
Max Koppers retweeted
bioRxiv: Cytoplasmic ribosomes hitchhike on mitochondria to dendrites dlvr.it/TDBq1d
Max Koppers retweeted
Conference in Grenoble 3th and 4th December 2024 "Organelles Transport in Health and Disease" --> Registrations are now open!! cell-transport.sciencesconf.…
Max Koppers retweeted
Excited to share our latest work on how the RNA binding protein HNRNPA2B1 regulates RNA abundance and motor protein activity in neurites! biorxiv.org/content/10.1101/…
Max Koppers retweeted
Local protein synthesis at neuromuscular synapses is required for motor functions dlvr.it/TCH2ly
Max Koppers retweeted
bioRxiv: Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation dlvr.it/TBwjxL
Max Koppers retweeted
Patient-specific responses to SMN2 splice-modifying treatments in spinal muscular atrophy fibroblasts biorxiv.org/cgi/content/shor… #biorxiv_molbio
Max Koppers retweeted
Excited to see out in @Nature my postdoc work! “Membrane prewetting by #condensates promotes tight junction belt formation” How do #tightjunctions form a belt in #epithelia sealing our body cavities? @Honigmann_Lab @mpicbg @BIOTEC_TUD w/ #Jülicher @mpi_pks
doi.org/10.1038/s41586-024-0…