Neuroimmunologist Principal Investigator, McAlpine Lab Researcher & Expert in Neuropsychiatric Long COVID Yale University School of Medicine
Connecticut
Joined June 2009
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Calling folks in the Northeast! We’re recruiting individuals with Long COVID and brain fog or cognitive difficulties for a Yale research study involving an MRI with gadolinium contrast. See the flyer for details, and please share! #longcovid
Lindsay McAlpine MD retweeted
Thanks to @BrainInflCollab for discussing my papers on #POTS, #MECFS and #LongCOVID as neuroimmune disorders and a possible CNS localization of POTS/dysautonomia to the dorsolateral medulla! 🧠
Read more about these emerging topics here:
tandfonline.com/doi/full/10.…
mdpi.com/2227-9059/13/1/166
Key brainstem regions help control heart rate, blood pressure, breathing, and the body’s inflammatory “brake” through the vagus nerve.
In this article, we examine neuroimaging and post-mortem findings in COVID-19, a recent neuroimmune hypothesis for POTS, the medulla’s role as an inflammatory thermostat, and how connective tissue laxity or mast cell activation may amplify vulnerability in a subset of patients.
Read more here: buff.ly/Lx71wkY
Lindsay McAlpine MD retweeted
#COVID19:
🟢 Prevent yourself from getting sick
🟢 Stay protected, especially if you are at higher risk of severe illness
🟢 Prevent spreading it to others if you do get sick
ALT Tips to prevent COVID-19: wash hands frequently, wear masks in crowds, improve ventilation, and get vaccinated.
ALT Guidelines to prevent spreading COVID-19 when sick include staying home, wearing a mask, covering coughs, frequent handwashing, and improving ventilation.
ALT Advice for those at higher risk of severe COVID-19: get vaccinated, wash hands frequently, wear masks in crowds, and improve ventilation indoors.
Lindsay McAlpine MD retweeted
So incredibly excited BioVie announced the positive results from our Phase 2 ADDRESS-LC trial of bezisterim in Long COVID and proud to have contributed! Thank you to our wonderful participants @BioVie_Pharma #LongCOVID
investors.bioviepharma.com/n…
Lindsay McAlpine MD retweeted
My patients often report improvement with GLP-1 RAs. Today one patient with #dysautonomia/#MCAS told me she is back to running after starting GLP-1 RA. 🏃♀️
📢 Our paper on post-COVID vaccination dysautonomia improving after GLP-1 RA was just published!
tandfonline.com/doi/full/10.…
Lindsay McAlpine MD retweeted
It has been such a pleasure to be a part of this! Looking forward to further data and next steps with the Phase 3 trial.
Today, we announced positive results from our Phase 2 signal finding ADDRESS-LC trial evalulating bezisterim for the treatment of neurological symptoms associated with Long COVID. Read: investors.bioviepharma.com/n…
$BIVI
So incredibly excited BioVie announced the positive results from our Phase 2 ADDRESS-LC trial of bezisterim in Long COVID and proud to have contributed! Thank you to our wonderful participants @BioVie_Pharma #LongCOVID
investors.bioviepharma.com/n…
Lindsay McAlpine MD retweeted
Today, we announced positive results from our Phase 2 signal finding ADDRESS-LC trial evalulating bezisterim for the treatment of neurological symptoms associated with Long COVID. Read: investors.bioviepharma.com/n…
$BIVI
Long COVID patients still lack access to specialized rehab. We urgently need disease-modifying therapies and individualized cognitive rehabilitation should become a standard part of care—just as it is for TBI and MS. #LongCOVID time.com/article/2026/07/06/…
Lindsay McAlpine MD retweeted
'STORM' is a short documentary about Scott Hugo. A story of Long COVID's impact on his life and family - a reminder of what is at stake in research on Long COVID.
His resilience humbles me.
Please watch and share 🙏🏼
youtu.be/rLtXh28Eejw
Pleased to share our latest COVID Mind Study @ Yale publication: "Vascular inflammation in neuropsychiatric long COVID" Elevated markers of endothelial adhesion in LC correlates with lower verbal fluency and learning.
doi.org/10.1016/j.bbih.2026.…
Lindsay McAlpine MD retweeted
🫀🧠 My new paper in a cardiology journal: appreciate that my cardiology colleagues like my ideas and don't reject my papers because my ideas are "too new" - a comment I got from an editor of another journal on a different paper that was rejected. 🤪
heartrhythmopen.com/article/…
Lindsay McAlpine MD retweeted
🧠🔬 Clinical Trial in Focus
The phase 2 ADDRESS-LC study (NCT06847191) is evaluating @BioVie_Pharma's bezisterim for neurological symptoms linked to Long COVID.
Includes expert insight from @McAlpineLabYale, of @YaleMed.
🔗 Read more: hubs.li/Q04f27wF0
HIRING! We are hiring postgraduate research associates starting June 2026. Please send talented folks interested in neuropsych Long COVID & PAIS our way!
postdocs.yale.edu/posts/2026…
Join our study site for the ADDRESS-LC Clinical Trial investigating Bezisterim in Long COVID!
Email: [email protected]
addresslongcovid.com/
Long COVID & Bezisterim Clinical Trial is now open at Yale!
Email: [email protected]
Website: addresslongcovid.com/
Lindsay McAlpine MD retweeted
Excited to share my friend and fellow Brown alum’s Neuro + Vertigo Physical Therapy account!
Education | Support | Treatment
instagram.com/balancingactre…
Lindsay McAlpine MD retweeted
Indeed, a subset of people with post-acute infectious syndromes, including #MECFS and #LongCovid, do recover, but others don't. The heterogeneity of these complex syndromes is not rooted in one's thoughts, but in one's pathophysiology. A number of #MS patients lead a fully functional, minimally symptomatic life while many others with MS are very disabled and symptomatic. Here is the info from the Center for Disease Control and Prevention - no ME activists there. What is needed for people to get better is not psychotherapy; what is needed are effective therapies like we have for MS.
cdc.gov/long-covid/living-wi…
People can recover from #mecfs #longcovid but being told it is a permanent medical condition by activist organisations like the MEA impairs or blocks recovery. MEA peddle chronicity rhetoric and this does harm
Lindsay McAlpine MD retweeted
Hot off the press! "CSF immune cell alterations in women with neuropsychiatric Long COVID" academic.oup.com/jid/article…
