Metabolic health, obesity & gut biology | Professor @HarvardMed | Chief, Interventional GI @MassGenBrigham | Founder, https://xitter.cf/t.co/4A7Ei7U7Qz | Contributor @ForbesHealth
Boston, MA
Joined May 2016
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The gut is much more than a digestive organ. It is a metabolic sensing and signaling system that helps shape how we respond to food, regulate appetite, and control metabolism.
Really enjoyed going deep on this with Andrew Huberman, from gut biology and the microbiome to obesity, GLP-1 therapies, and endoscopic treatments.
The new Huberman Lab episode is out: Best Tools for Gut Health and Weight Loss | Dr. Chris Thompson
0:00 Dr. Chris Thompson
2:16 Digestive Tract, Gut Hormones & Nutrient Absorption
8:06 Colon Microbiome & Colon Cancer Screening
11:13 Sponsors: LMNT & Lingo
13:40 Swallowing Problems & Zenker's Diverticula
16:08 Bowel Movements & Constipation
18:28 Fiber, Resistant Starch & the Gut Barrier
21:50 Intermittent Fasting & the Gut Microbiome
23:38 Fermented Foods, Microbial Diversity & Butyrate
27:12 H. pylori, Stress & Stomach Ulcers
30:20 GLP-1 Medications: Benefits & Limitations
33:42 Lower GLP-1 Doses, Weight Regain & Muscle Loss
37:35 GLP-1 Side Effects, Food Noise & Apathy
39:49 Bariatric Surgery & Medical Innovation
46:07 Sponsor: AG1
47:44 Hunger & Satiety: Ghrelin, CCK, GIP & GLP-1
50:01 Retatrutide & Combining Hormonal Targets
52:55 Ultra-Processed Foods, Overeating & Leptin
55:32 Incretin Discovery, Exendin-4 & the Gila Monster
59:35 Endoscopic Ultrasound & Pancreatic Biopsy
1:07:40 Early Metabolic Markers, CGMs & Fasting Insulin
1:13:06 Insulin Resistance & Metabolic Flexibility
1:15:53 Sponsor: Function
1:17:35 Patient Data, Screening & Treatment Adoption
1:26:31 AI, Robotics & Improving Procedures
1:29:27 Choosing a Surgeon & Measuring Procedure Quality
1:35:29 Image Guidance & Hyperspectral Imaging
1:37:19 Sponsor: Our Place
1:38:56 Diagnostics & Targeted Metabolic Treatments
1:42:45 Gastric Bypass, Foregut Exclusion & Diabetes
1:47:59 Duodenal Liners & Mucosal Resurfacing Research
1:52:58 Gut Permeability, Inflammation & Fatty Liver
1:59:39 Artificial Sweeteners, Fructose, Fats & Omega-3s
2:05:00 Resistance Training, Zone 2 Cardio & Intervals
2:06:31 Weight Set Point & Metabolic Adaptation
2:08:13 Endoscopic Sleeve Gastroplasty & Fundus Ablation
2:10:30 Magnetic Intestinal Connections & Combined Treatments
2:16:52 GLP-1 Gene Therapy Research
2:22:13 Innovation, Problem Solving & Teamwork
2:25:58 Zero-Cost Support, Sponsors & Neural Network Newsletter
Includes paid partnerships.
Congratulations!! We are all so proud to have been a part of your training @BrighamGI and are looking forward to the amazing things you will accomplish.
Honored and humbled to be selected. Big thank you to Elizabeth Blanton and Peter S Wareing! Could not have been possible without the unwavering support and leadership from @eamonnquigleymd! @HMethodistMD
Metabolic disease often begins with compensation, not failure.
Blood glucose can still look normal because insulin is working harder to keep it there.
The abnormality is not always the number you see. Sometimes it is the effort required to keep that number normal.
I explore this in more depth in my recent Forbes article: forbes.com/sites/christopher…
Chris Thompson, MD retweeted
Congrats @hubermanlab !
#1 NYT Best Seller across all categories.
Awesome to see given how much went into the writing of this book.
Chris Thompson, MD retweeted
Nobody deserves this more than @hubermanlab .
He put an ENORMOUS amount of time into this book.
He could've thrown some sloppy AI at it and be done in days.
He chose the hard path, and literally spent years on it.
Couldn't be happier for him.
Congrats @hubermanlab !
#1 NYT Best Seller across all categories.
Awesome to see given how much went into the writing of this book.
Two people can have the same fasting glucose: 92 mg/dL.
One may need very little insulin to keep it there.
The other may need several times as much.
Glucose tells you the result.
Insulin tells you the cost.
That is how metabolic disease can remain hidden for years.
This is one of the concepts I explore in my new Forbes article on recognizing metabolic disease before conventional markers become abnormal:
forbes.com/sites/christopher…
Metabolic disease can start years before your A1C turns abnormal.
Insulin resistance may build quietly while glucose still looks “normal.”
In my new Forbes article, I lay out 6 measurable layers of metabolic disease, and how to detect them earlier.
Catch Metabolic Disease Years Before Your A1C Flags It via @forbes forbes.com/sites/christopher…
Chris Thompson, MD retweeted
5,103 people watching live now!
If you are not watching, you still have time to connect at belglive.com/live/
Chris Thompson, MD retweeted
@MetabolicEndo demonstrating the megaplication technique for endoscopic gastric remodeling with Endomina!
@BariatricLive @endotools
Chris Thompson, MD retweeted
Endomina directly from Boston, with Christopher Thompson!
@MetabolicEndo
Chris Thompson, MD retweeted
Coming next: Bariatric Endoscopy Antral Myotomy (BEAM), with @MetabolicEndo
watch live: belglive.com/live/
Chris Thompson, MD retweeted
A closer look at expertise.
Follow every technical step and clinical decision as the case unfolds live!
Thank you for your participation,
@MetabolicEndo
Chris Thompson, MD retweeted
Fascinating look at bariatric endoscopic antral myotomy (BEAM), demonstrated by the pioneer of the technique himself
@MetabolicEndo
@BariatricLive
Chris Thompson, MD retweeted
Welcome to the 7th Bariatric Endoscopy Live Global!
Watch 12 hours of live cases at belglive.com/live/
Chris Thompson, MD retweeted
It’s Friday!!! We are only 2 days away for Bariatric Endoscopy Live Global - BELG 2026!
Register now for free at belglive.com/#/
Chris Thompson, MD retweeted
It’s tomorrow! We are 20 hours away for the 7th Bariatric Endoscopy Live Global!!!
You still have time to register at belglive.com/#/
Check out our agenda and join us for 12 hours of live cases with the most renowned Bariatric Endoscopists in the World!
