MD/PhD. Rheumatologist. Lecturer, Department of Allergy and Rheumatology, University of Tokyo Hospital. Into complex trait genetics and all things immunology.
Joined January 2022
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Mineto Ota retweeted
Our paper is out today in Cell, "Trans-regulatory gene mapping prioritizes disease drivers in asthma", cell.com/cell/fulltext/S0092… 🎉 GWAS hands us thousands of disease-linked variants, but the genes that actually drive the disease often aren't the ones sitting at those variants.
Mineto Ota retweeted
We built a joint experimental and computational platform for scalable multi-modal single-cell chemical screens — profiling RNA, protein (including phospho-signaling), and chromatin accessibility responses to thousands of small molecule perturbations in parallel. biorxiv.org/content/10.64898…
Mineto Ota retweeted
Together with Emma Dann, we are thrilled to present a massive new Perturb-seq atlas of 22M primary CD4+ T cells, from 4 donors, across 3 timepoints – the result of a decade-long collaboration between the Marson (@MarsonLab) and Pritchard (@jkpritch) labs.
🧵👇
Mineto Ota retweeted
How well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS.
In a new pre-print with @PGerlach98341, Jeff Spence, and @jkpritch, we find that TWAS gets the sign wrong around 20-30% of the time!
1/n
Mineto Ota retweeted
Another exciting paper from @GladstoneInst Genomic Immunology - check out our latest preprint on myeloid cell editing: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by @HyuncheolJung and @pascal_devant
Mineto Ota retweeted
Exciting new joint study out in @Nature today from Mineto Ota (Marson and @jkpritch labs) - Causal modelling of gene effects from regulators to programs to traits nature.com/articles/s41586-0…
I believe that understanding the genetic architecture of complex traits can transform clinical practice. We’ve built—and are still growing—a patient-derived immune cell dataset (see previous work below). If you’re looking for a postdoc, feel free to DM me!
pubmed.ncbi.nlm.nih.gov/3393…
After time in the Bay Area, I’ve started a new role as Lecturer in the Department of Allergy and Rheumatology @UTokyo_News_en . We’re the group of clinicians who see patients with autoimmune diseases, while researching new treatments, patient stratification, etc.
Excited to see our paper published in @Nature ! Huge thanks to Jeff, @tkyzeng, Emma, @TheNikhilMilind, Alex, @jkpritch, and everyone who helped make it happen--and to the editors and reviewers for their thoughtful feedback! Article link: rdcu.be/eT5sL
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight.
I'm excited to share our new work combining genetic associations and Perturb-seq to build interpretable causal graphs, out today in @Nature:
Mineto Ota retweeted
How do GWAS and rare variant burden tests rank gene signals?
In new work @Nature with Jeff Spence, @jkpritch, and our wonderful coauthors we find the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
nature.com/articles/s41586-0…
Mineto Ota retweeted
It was fun writing this short piece on the omnigenic model. Sharing it here, though it's a painful time as my family, along with millions of others, is at risk in Iran and the region.
New online! Making sense of the polygenicity of complex traits bit.ly/43X5RMA
Mineto Ota retweeted
I'm delighted to present our nationwide effort to identify genetic determinants of child health and development in Japan.
medrxiv.org/cgi/content/shor…
Mineto Ota retweeted
New approach to discovering the biology of GWAS signals “by combining quantitative estimates of gene-trait relationships from loss-of-function burden tests with gene-regulatory connections inferred from Perturb-seq experiments in relevant cell types.”
Thank you Jonathan for the elegant explanation of our recent work!
We dove into how we can model the gene regulatory architecture of complex traits with 1) gene effects from LoF burden tests and 2) Perturb-seq.
It’s been an incredibly exciting and thought-provoking journey!
Mineto Ota retweeted
In a country where women's voices are silenced, a young Iranian woman, Parastoo Ahmadi, held an 'imaginary' concert. Fearless of the punishment that awaits, she sang and inspired the dream of a free Iran. A true symbol of resistance.
Full video here: youtu.be/oYcaDHEnhbU?si=Vipp…
Mineto Ota retweeted
Excited to share the latest from the @MarsonLab! An investigation of context-specific gene regulation in T cells, which led to dynamic mechanisms required to control T cell rest and activation.
Published today in @Nature thanks to the work of many!
nature.com/articles/s41586-0…
Mineto Ota retweeted
In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox:
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
