Blueberry muffin syndrome
Had been reported to be a manifestation of either dermal erythropoiesis or neoplastic infiltrations
Dermal erythropoiesis may be caused by
*congenital virus infections, such as rubella, cytomegalovirus, coxackie virus B2, and parvovirus B19,
*or by severe hemolysis associated with Rh incompatibility, blood group incompatibility, hereditary spherocytosis, and twin–twin transfusion syndrome
Among the neoplastic diseases with the presentation of blueberry muffin babies,
*neuroblastoma was the most common, whereas rhabdomyosarcoma, Langerhans cell histiocytosis, and leukemia were less frequently reported.
𝗖𝗲𝗳𝗼𝘁𝗲𝘁𝗮𝗻
●Aside from nitroimidazoles like metronidazole, perhaps the second most-recognized antimicrobial class associated with disulfiram-like reactions is cephalosporin antibiotics,
*specifically those that contain a methylthiotetrazole (MTT) substituent (e.g., cefotetan, cefoperazone, cefamandole).
****
●Cefotetan is a second-generation cephalosporin antibiotic used for treating a wide range of infections, including
*intra-abdominal, skin, bone, respiratory, and urinary tract infections.
●It can also be used for prophylaxis in gastrointestinal surgeries and
*contains a unique side chain that may lead to rare side effects like prolongation of prothrombin time and a disulfiram-like reaction.
🦠 𝗖𝗲𝗳𝗼𝘁𝗲𝘁𝗮𝗻 can cause a 𝗱𝗶𝘀𝘂𝗹𝗳𝗶𝗿𝗮𝗺-𝗹𝗶𝗸𝗲 𝗿𝗲𝗮𝗰𝘁𝗶𝗼𝗻 due to its ability to 𝗶𝗻𝗵𝗶𝗯𝗶𝘁 𝗮𝗹𝗱𝗲𝗵𝘆𝗱𝗲 𝗱𝗲𝗵𝘆𝗱𝗿𝗼𝗴𝗲𝗻𝗮𝘀𝗲, an enzyme involved in alcohol metabolism.
✅ This 𝗿𝗲𝗮𝗰𝘁𝗶𝗼𝗻 𝗶𝘀 𝘀𝗶𝗺𝗶𝗹𝗮𝗿 𝘁𝗼 𝘁𝗵𝗮𝘁 𝗰𝗮𝘂𝘀𝗲𝗱 𝗯𝘆 𝗱𝗶𝘀𝘂𝗹𝗳𝗶𝗿𝗮𝗺, a drug used to deter alcohol consumption. Patients taking cefotetan 𝘀𝗵𝗼𝘂𝗹𝗱 𝗯𝗲 𝗮𝗱𝘃𝗶𝘀𝗲𝗱 𝘁𝗼 𝗮𝘃𝗼𝗶𝗱 𝗮𝗹𝗰𝗼𝗵𝗼𝗹 𝗱𝘂𝗿𝗶𝗻𝗴 𝗮𝗻𝗱 𝗳𝗼𝗿 𝗮𝘁 𝗹𝗲𝗮𝘀𝘁 𝟳𝟮 𝗵𝗼𝘂𝗿𝘀 𝗮𝗳𝘁𝗲𝗿 𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 to prevent this reaction.
🎯 𝙔𝙤𝙪 𝙘𝙖𝙣 𝙫𝙞𝙨𝙞𝙩 𝙢𝙮 𝙔𝙤𝙪𝙏𝙪𝙗𝙚 𝙘𝙝𝙖𝙣𝙣𝙚𝙡 𝙛𝙤𝙧 𝙖𝙢𝙖𝙯𝙞𝙣𝙜 𝙘𝙡𝙞𝙣𝙞𝙘𝙖𝙡 𝙥𝙝𝙖𝙧𝙢𝙖𝙘𝙤𝙡𝙤𝙜𝙮 𝙫𝙞𝙙𝙚𝙤𝙨:youtube.com/@pharmacybyasim
Lymph nodes of the head and neck and the regions that they drain.
Source: Gaddey et al. Am Fam Physician. 2016
brownmedpedsresidency.org/ly…
An up-to-date stepwise approach to the diagnosis of Polymyalgia Rheumatica.
oaepublish.com/articles/2574…
