Asst. Professor @Harvardmed and @BrighamAnes

Boston, MA
Joined July 2010
Our new paper is out in @NatureNano We describe a non-viral gene delivery platform that delivers mRNA precisely to damaged cartilage in osteoarthritis and self-regulates targeting and expression as disease severity increases. nature.com/articles/s41565-0… massgeneralbrigham.org/en/ab…
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Huge congratulations to @DewaniMahima and @jgao_umass for leading this work. Grateful to our collaborators Li Zeng, Anjali Mamidwar, @MrJeffKarp and the rest of the team who made this possible. Excited about what this means for precision gene therapies in degenerative diseases!
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🔥Our latest work is out in PNAS! We report a mechanically resilient hydrogel that enables sustained, localized delivery of therapies for post-traumatic osteoarthritis, without breaking down under physical activities like running! pnas.org/doi/10.1073/pnas.24… @PNASNews
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HUGE thanks to my collaborators @MrJeffKarp and Joerg Ermann, and congratulations to the entire team for the tremendous work over the years. Thank you @NIH @NIH_NIAMS @DeptofDefense @NFLPA @RheumResearch for the support. @MassGenBrigham @BrighamWomens @harvardmed @BrighamAnes
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Blood–brain-barrier-crossing lipid nanoparticles (BLNPs). Wonderful academia and industry collaborations @IcahnMountSinai @biogen @OhioState! Thanks @NIGMS & @NIDAnews! Thanks @NatureMaterials editor and reviewers!
CONGRATULATIONS to my colleagues @IcahnMountSinai for developing lipid nanoparticle system capable of delivering mRNA to brain via intravenous injection, a challenge that has long been limited by protective nature of #BloodBrainBarrier. @NatureMaterials👉 nature.com/articles/s41563-0…
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A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is >99.9% effective & contains no drugs 1/
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Nitin Joshi retweeted
🔥 New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses: “The researchers developed the formulation and studied its ability to capture respiratory droplets in a 3D-printed replica of a human nose. They showed that when sprayed in the nasal cavity replica, PCANS captured twice as many droplets as mucus alone.  “PCANS forms a gel, increasing its mechanical strength by a hundred times, forming a solid barrier,” said primary author John Joseph, PhD, a former postdoctoral fellow at Brigham and Women’s Hospital. “It blocked and neutralized almost 100% of all viruses and bacteria we tested, including Influenza, SARS-CoV-2, RSV, adenovirus, K Pneumonia and more.” Experiments in mice showed that a single dose of the PCANS nasal spray could effectively block infection from an influenza virus (PR8) at 25 times the lethal dose. Virus levels in the lungs were reduced by >99.99%, and the inflammatory cells and cytokines in the lungs of PCANS-treated animals were normal.”
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In a preclinical study, @NJoshiBWH, @MrJeffKarp and their collaborators have created and tested an innovative drug-free nasal spray that has the potential to be a public health tool in reducing respiratory diseases. buff.ly/3XXwDTm
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HUGE congratulations to John Joseph, Helna Mary Baby, Joselyn Rojas Quintero, @MrJeffKarp , Yohannes Tesfaigzi and the rest of the incredible team! Thank you to @steppingstrong1 for the wonderful support! @BrighamWomens @harvardmed @BrighamAnes
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New review from our lab discussing "Precision drug delivery to the central nervous system using engineered nanoparticles” in @NatRevMater with @MrJeffKarp. Huge Congratulations to @jgao_umass and the team. nature.com/articles/s41578-0… @massgeneralbrigham @harvardmed @BrighamWomens
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Check out our review article "Gene therapies for CNS diseases: modalities, delivery, and translational challenges" in @NatRevNeurosci Congratulations to @jgao_umass for leading this effort in collaboration with @MrJeffKarp, @RudyTanzi, and @AnaGriciuc. rdcu.be/dLic2
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please join us in welcoming Dr. Jingjing Gao to UMass BME!! Dr. Gao will be joining us as an assistant professor this fall. we are so thrilled to have you!🥳 @JGao66
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Huge congratulations Jingjing!! @JGao66. I am really proud of you!!! Looking forward to following all the exciting work from your lab at @UMassAmherst!
Thrilled to announce that I will the BME department at UMass Amherst as an Assistant Professor this Fall! Incredibly grateful to my mentors @MrJeffKarp @NJoshiBWH @UMassThaiGroup for their guidance and support along this journey!! Thank the support from my family as always!
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