@NatureBiotech

Publishing the best of biotech science and business. Find us on Bluesky, Facebook & Instagram. Part of @SpringerNature and @NaturePortfolio.

 NY/CA/London/Berlin
nature.com/nbt
Joined June 2009
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4.8KMedia
An effective CRISPR RNA occlusion strategy enhances mismatch detection when using Cas13 go.nature.com/4oglebG rdcu.be/ZaS8Y5zE3WVa

RNA structure modulates Cas13 activity and enables mismatch detection

Nature Biotechnology - An effective CRISPR RNA occlusion strategy enhances mismatch detection when using Cas13.

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Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells nature.com/articles/s41587-0…
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Recordanelles for transcriptome-wide single-cell RNA recording in human cells nature.com/articles/s41587-0…
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Regeneron approval brings relief for ‘second skeleton’ bone disorder nature.com/articles/s41587-0…

Regeneron approval brings relief for ‘second skeleton’ bone disorder

Nature Biotechnology - The newly approved antibody stops abnormal bone growth in patients with the devastating disease fibrodysplasia ossificans.

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Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints go.nature.com/4aRDpk8 rdcu.be/ZqESYB6vavSa

Antibody-lectin chimeras for glyco-immune checkpoint blockade

Nature Biotechnology - Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.

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Decoding systemic vascular health and hypertensive disorders in pregnancy through retinal imaging and Visionary AI nature.com/articles/s41587-0…
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The eye as a biomarker: why retinal AI could reshape how trials screen and stratify pregnant patients #NBTintheNews clinicaltrialvanguard.com/ar…

The Eye as a Biomarker: Why Retinal AI Could Reshape How Trials Screen and Stratify Pregnant...

A Nature Biotechnology retinal AI model detects preeclampsia and gestational hypertension risk non-invasively, and its trial implications go far beyond…

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Genetic code expansion enables plant-directed control of bacterial activity nature.com/articles/s41587-0…
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Engineered human Argonaute 2 for targeted C-to-U RNA base editing nature.com/articles/s41587-0…
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Stem cell repair of injured monkey spinal cords restores hand function in 53% of trials go.nature.com/3LKx0ge rdcu.be/AYFYsSnnpwZa

Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell...

Nature Biotechnology - Stem cell repair of injured monkey spinal cords restores hand function in 53% of trials.

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Deep learning perturbation models can outperform baselines on calibrated metrics - @ShiftBioscience nature.com/articles/s41587-0…
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New calibration framework improves confidence in AI virtual cell models #NBTintheNews genengnews.com/topics/artifi…

New Calibration Framework Improves Confidence in AI Virtual Cell Models

Metrics such as mean squared error and control-referenced Pearson correlation are frequently miscalibrated, according to the authors.

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Flawed benchmarks hid AI success in gene perturbation prediction #NBTintheNews bioengineer.org/flawed-bench…

Flawed Benchmarks Hid AI Success in Gene Perturbation Prediction

A new calibration framework shows that common benchmarking metrics masked real perturbation-specific signal, and that deep learning models can outperform simple baselines when evaluated properly.

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Discovery and protein language model-guided design of hyperactive transposases go.nature.com/4gXLGEw
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AI-designed proteins surpass nature in genome editing #NBTintheNews via @digwatchworld dig.watch/updates/ai-designe…

AI-designed proteins surpass nature in genome editing | Digital Watch Observatory

The discovery could accelerate gene and cell therapies for cancer and rare diseases.

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Scientists use generative AI to build better proteins for editing DNA #NBTintheNews thebrighterside.news/post/sc…

Scientists use generative AI to build better proteins for editing DNA

A genome search and protein language model produced new DNA-moving proteins, including one that doubled targeted insertion in lab tests.

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In Brief: @FDA greenlights @ionispharma's #Zanvastro, the first disease-modifying drug for a rare, progressive and often fatal neurological condition known as Alexander disease nature.com/articles/s41587-0… rdcu.be/ufenZXWBDYda

FDA nod for rare neurology drug

Nature Biotechnology - FDA nod for rare neurology drug

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Five questions with Bowen Li nature.com/articles/s41587-0…

Five questions with Bowen Li

Nature Biotechnology - A true multidisciplinary scientist, Bowen Li finds that some of the most interesting questions are located precisely at the boundaries between fields.

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Each year, we highlight companies that received sizeable early-stage funding in the previous year. @bioptimus_ai is developing multimodal and multiscale AI pathology models for biomarker and drug treatment prediction nature.com/articles/s41587-0…

Editor’s pick: Bioptimus

Nature Biotechnology - Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Bioptimus is developing multimodal and multiscale AI...

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Nature Biotechnology retweeted
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@NatureOct 17
How much do PhD students earn? The first comprehensive overview of PhD income shows vast imbalances across much of Europe Read the full story: go.nature.com/4B8qAwD go.nature.com/4zwzdiR
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Ke Cheng, Ph.D.@KeChengLabOct 13
Many thanks to @NatureBiotech for selecting our work as the front cover. Congratulations again to @ShuoL_ and the entire team.
Nature Biotechnology
@NatureBiotechOct 12
The October issue is live nature.com/nbt/volumes/44/is… On the cover, engineered inhalable exosomes display a bispecific T cell activator targeting a cancer cell along with a T cell. PD1 and FZD on the exosomes block tumor-cell PD-L1 signaling and neutralize tumor-secreted Wnt, respectively go.nature.com/496Ins7 rdcu.be/avnjBsFZKzFa
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Human Cell Atlas@humancellatlasOct 13
Fabulous to see this editorial from @NatureBiotech, highlighting HCA achievements and technologies over the past 10 years, and the ambitious plans for the future. Watch this space! #HumanCellAtlas #Genomics
Nature Biotechnology
@NatureBiotechOct 12
Ten years, tens of millions of cells nature.com/articles/s41587-0…
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🎉 Wonderful Q&A with @UofT researcher Bowen Li (@BowenLi_Lab)! @NatureBiotech nature.com/articles/s41587-0… #MedX #MedTwitter #MedEd #AIinHealthcare #HealthAI #HealthTech

Five questions with Bowen Li

Nature Biotechnology - A true multidisciplinary scientist, Bowen Li finds that some of the most interesting questions are located precisely at the boundaries between fields.

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Highly multiplexed mammalian metabolic engineering with a shotgun approach - @sudpinglay @JefBoeke nature.com/articles/s41587-0…
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Shotgun genetic engineering lets mammalian cells stumble onto new metabolic pathways #NBTintheNews scienmag.com/shotgun-genetic…

Shotgun genetic engineering lets mammalian cells stumble onto new metabolic

A Nature Biotechnology commentary highlights how shotgun genetic engineering, which tests vast random combinations of genes in mammalian cells, enabled the discovery of functional new pathways for...

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T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function go.nature.com/3Jp6B72 rdcu.be/4C6R4B1ZJaWa

Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity

Nature Biotechnology - T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.

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Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies for thymus regeneration #NBTNV go.nature.com/4r1A8Vp rdcu.be/eOpTg

Mesenchymal cells rebuild the thymus

Nature Biotechnology - Cross-species analysis of thymic stroma in mice and humans reveals a subset of mesenchymal cells that are capable of restoring thymic function, which suggests new strategies...

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