NIHR Clinical Lecturer in Neurology at the Sheffield Institute for Translational Neuroscience (SITraN). Researching Parkinson's Disease. All thoughts my own
Joined June 2020
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- Followers244
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Tom Payne retweeted
Is mitochondrial pathology universal in idiopathic Parkinson's disease? We find widespread mitochondrial pathology in the brain of ~25% of individuals with PD, linked to a non-tremor dominant motor phenotype. Could this be a "mitoPD" subtype?
nature.com/articles/s41467-0…
Thank you and the wider team for having me!
Really interesting update about Parkinson's research from @NeuroPayne here at Derby. So much important work being done- Thank you! 👏
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Really enjoyed the day lots of interesting talks and exciting research happening in our @SheffieldBRC and @CRFSheffield
On #WorldParkinsonsDay I'm very proud to be part of a team and institute working towards effective disease modifying treatments for Parkinson's
Each day, 80 people in the UK are newly diagnosed with #ParkinsonsDisease which affects over six million people globally. There is currently no cure. Working closely with patients, our researchers are transforming the understanding of Parkinson’s disease. 🧵 #WorldParkinsonsDay
ALT Outside of SITraN building
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Tom Payne retweeted
📢 Another exciting opportunity to join the NIHR Sheffield BRC as a #ClinicalFellow!
Work on stimulating projects across our Translational #Neuroscience theme.
Get mentored by leading clinicians and scientists.
🔗 Learn more & apply here: bit.ly/3vw09nm
Nothing makes you realise how fast the last 12 months have flown by more than the annual researchfish submission email. Felt like I only did it last month. Potential to harness this for time travel to the future?
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As a #DoctorWho fan and scientist this is absolutely brilliant! Maybe I need to start looking at framing all my Parkinson’s research in the context of Doctor Who. Very entertaining read @Richard_D_Riley
A new #DoctorWho episode shown during the festive period, especially on Christmas Day, is associated with lower death rates in the subsequent year across the UK, finds new #ChristmasBMJ study
#DrWho @Richard_D_Riley
bmj.com/content/383/bmj-2023…
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Really proud to be part of this paper and another big chunk of work from my PhD published! Many thanks to funders @MichaelJFoxOrg and all participants involved!
It’s paper time! Our paper investigating mitochondria in fibroblasts and MR spectroscopy imaging from the same people with Parkinson’s is out in Brain.
Great work everyone @Toby__Burgess @NeuroPayne @neuroshef
academic.oup.com/brain/advan…
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Fantastic paper, congrats!
Congrats to all involved! 🙌🏽🎉Neuroinflammation is linked to dementia risk in Parkinson’s disease academic.oup.com/brain/artic…
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Very proud that our phase 2 study of UDCA in Parkinson’s has been published by @movedisorder! Many thanks to all participants, collaborators and funders inc. Jon Moulton charity trust and @CureParkinsonsT! @SheffieldBRC @neuroshef @foltynie #parkinsons
doi.org/10.1002/mds.29450
@mr_spectroscopy you may also be interested in this, we used 31P-MRS to assess target engagement of UDCA in the midbrain
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Tom Payne retweeted
New double blind study results of Ursodeoxycholic acid (UDCA) in #parkinsons as a possible mitochondrial rescue agent. Great study by Bandmann and colleagues, 'Midbrain 31P-MRS demonstrated an increase in both Gibbs free energy and inorganic phosphate levels in the UDCA treatment group compared to placebo, reflecting improved ATP hydrolysis. Sensor-based gait analysis indicated a possible improvement of cadence (steps per minute) and other gait parameters in the UDCA group compared to placebo. In contrast, subjective assessment applying the MDS-UPDRS-III failed to detect a difference between treatment groups.' Interesting finding which raise the question as to what outcomes are sensitive enough to detect changes. movementdisorders.onlinelibr…
Tom Payne retweeted
🚶♂️🔍 Join our study on visualizing walking data!
🔑 Share your input! People with PD, MS, COPD, and hip fracture, we need your experiences.
🌟Help us create meaningful visualizations. Register for our short study: forms.office.com/e/9gbN1Ytyt…
#WalkingData #PD #MS #COPD #HipFracture
Come work with us @neuroshef! We are advertising for PhD's including this fantastic project developing an in vivo MRI model of bioenergetic connectivity in Parkinson's disease #Parkinsons #PhD #MRI #picturesofbrainsarecool
findaphd.com/phds/program/jo…
This is huge, publishing in journals has a whole host of problems and it is encouraging to see a group of academics standing for what they feel is right. I’m sure the new journal @ImagingNeurosci will be far superior and look forward to reading it! theguardian.com/science/2023…
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Unexpected highlight of the week was getting my cat printed onto a coffee which is not something I knew I needed in my life. I’m therefore now pivoting all my future research into printing my cat onto various beverages #CatsOfTwitter
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Winding down and preparing for travel back home, thanks for having me @AANmember and I thoroughly enjoyed my first in-person #AANAM. Some fantastic sessions and I got to see the celtics in the playoffs, great week!
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Fantastic achievement, congratulations and well done to @DrEmHenderson and the whole team, looking forward eagerly to the results!
We’ve done it! We’ve done it!!!
🥳🎊🍾🎉
We’ve successfully reached our target with 600 incredible people with #Parkinsons agreeing to take part in this trial of a drug to prevent falls.
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Having a great time at #AANAM in Boston this week. Looking forward to presenting our work on multimodal mechanistic disease stratification in Parkinson’s and particularly phosporus spectroscopy in the movement disorders invited science session! #Parkinsons @AANmember
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Talk done! Thank you #AANAM Generated some interesting questions and all presenters from the session were fantastic, really interesting afternoon! Many thanks to moderaters @IreneMalatyMD and @AlbertoEspay for hosting the session!
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