Neuroscience grad student in the Josselyn lab @UofT. Studying memory allocation and playing with tiny microscopes.
Joined August 2012
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Neurochatter retweeted
High-throughput two-photon volumetric brain imaging in freely moving mice biorxiv.org/cgi/content/shor… #biorxiv_neursci
Neurochatter retweeted
Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye!
The dye is tartrazine, used in Doritos!
science.org/doi/10.1126/scie…
Neurochatter retweeted
Excited to share my PhD work in @pgolshani 's lab designing and building low-cost miniature 2P microscopes with everyone! They cost < $10k USD (even at low production runs), are fitted with 2 on-board SiPM detectors, and are completely open-source! 1/5 biorxiv.org/content/10.1101/…
Neurochatter retweeted
Excited to share our work with @mlphillips17 about 9-color calcium imaging under a GRIN miniscope!
Functional imaging of nine distinct neuronal populations under a miniscope in freely behaving animals.
biorxiv.org/content/10.1101/…
Neurochatter retweeted
Drift of neural ensembles driven by slow fluctuations of intrinsic excitability biorxiv.org/cgi/content/shor… #biorxiv_neursci
Neurochatter retweeted
Very proud to have played a part in this great paper from Tad Blair @DanielBAharoni Jason Cong and many others on a hardware system for real-time decoding of miniscope recordings. This will change the game.
elifesciences.org/articles/7…
Neurochatter retweeted
Introducing OHRBETS - the low-cost, open-source ecosystem for head-fixed behavioral experiments in rodents. Unparalleled control, precise measurement, and concurrent neural activity modulation.
New paper out from our group! We looked at the formation, extinction and reinstatement of a drug reward engram in the lateral amygdala. Turns out fear and reward engrams aren't so different - both require high neuronal excitability to form
[1/3]
New in @npp_journal: Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice led by Albert Park and Alexander Jacob @Neurochatter, labs of @JohnGHowland and Sheena Josselyn @sjo09
nature.com/articles/s41386-0…
We also found that even after extinction, this reward engram persisted. Artificially reactivating it caused mice to remember the extinguished association. And silencing the engram prevented drug-induced reinstatement. [2/3]
So while a reward engram goes dormant after extinction learning, it's both necessary and sufficient for reinstatement later on.
Shoutouts to the twitterless Albert Park and Liz Hsiang for spearheading this project! And to @sjo09 and @JohnGHowland for making it all happen. [3/3]
Neurochatter retweeted
📣 📣 📣 Excited to highlight our latest publication led by the super talented @Shikun_Hou out today in #eNeuro. Introducing Pi USB Cam – an affordable, simple, powerful, & versatile DIY video recording solution for behavioral neuroscientists 🧵
bit.ly/3AUpGWs
Neurochatter retweeted
There is no central repository for 3D printed objects used in neuroscience research. So we created one. Please read about the repository and consider sending in your designs at the link below. #openscience #neurotwitter #3Dprinting
edspace.american.edu/openbeh…
Neurochatter retweeted
Important concerns!
“Multiphoton holographic photostimulation induces potassium-dependent spike silencing in label-free mouse cortex in vivo” biorxiv.org/content/10.1101/…
Neurochatter retweeted
Joe's work on EDoF-Miniscope that integrates a diffractive optical element to a fluorescence miniscope
doi.org/10.1101/2022.08.05.5…
Neurochatter retweeted
Hemoglobin (Hb) absorbs light and affects optical measures in vivo. In our new @CellRepMethods paper, @WeitingZhangUNC, @TzuhaoHarryChao et al. from @ShihYYI lab @BRIC_UNC and Cui Lab @NIEHS describe a method to correct Hb absorption in fiber photometry: cell.com/cell-reports-method…
Neurochatter retweeted
Holographic stimulation of opposing amygdala ensembles bidirectionally modulates valence-specific behavior biorxiv.org/cgi/content/shor… #biorxiv_neursci
Neurochatter retweeted
Computational Miniature Mesoscope V2: >7mm FOV, < 10um lateral and < 25um axial resolution; a fast & efficient 3D Shift-Variant model + a fully simulation-trained DNN generalizes to real experiments. Another impressive effort led by @xue_yujia.
arxiv.org/abs/2205.00123
ALT Computational Miniature Mesoscope (CM2) V2
Neurochatter retweeted
Out now in @naturemethods : Detecting and Correcting false transients in calcium imaging with SEUDO! (w/ @JeffOnTheBrain @jpillowtime David Tank, @sueannkoay & @enieh36 )
rdcu.be/cJ0uF
Warning: You may never be as comfortable with automated calcium analysis again!
Neurochatter retweeted
Do you want to do real-time alignment, analysis, decoding, and feedback with miniscope data? Zhe Chen, Garrett Blair, Daniel Aharoni, Jason Cong, Tad Blair and colleagues as a part of our UCLA NeuroNex Initiative have done just this. Open-source win.
biorxiv.org/cgi/content/shor…