
Research team @imperialcollege studying heart failure to develop novel patients stratification and precision medicine approaches🫀
London, England
Joined February 2023
- Tweets40
- Following43
- Followers43
- Likes51
Noseda_lab retweeted
What an atlas from the @TeichLab and @NosedaLab! 🤯
Sam Barnett (@sn_barnett), @Ana_Cujba, and Ling Yang (@edenling3) developed a #vascular cell atlas integrating #SingleCell data of 19 organs and tissues.
🔖 @NatureMedicine: go.nature.com/3Ou3B8e
💬: bit.ly/4g70Sxm
Noseda_lab retweeted
Very proud to see three medical students from our intercalated BSc in Cardiovascular Sciences @ImperialMed @ImperialNHLI presenting their research at #ESCCongress2024 @escardio 👏👏👏
@birdseylab @bp_halliday @NosedaMichela @Dr_Keene @LouiseDResp @krzysmac
Noseda_lab retweeted
We're very excited to welcome Professor @Barbara_Casadei as our new Head of @imperialNHLI from 1 October this year! We can't wait to welcome you to #OurImperial
blogs.imperial.ac.uk/senior-…
Noseda_lab retweeted
Please join us on 6th March 2024 @UCLeyefor talks from ECRs and PIs followed by a wine and cheese reception, all for free due to @lvbforum.
Noseda_lab retweeted
🫀We’re looking for a new PhD student!
Applications are now open for a 4-year @TheBHF funded MRes/PhD studentship at @ImperialNHLI between the Noseda, Rashid and Gorelik labs.
findaphd.com/phds/project/de…
Application deadline 23rd February
Noseda_lab retweeted
#Spatial Preprint🚨We've integrated #Histopathology, Spatial & #Singlecell #Transcriptomics to unravel #COVID19 🫁damage complexities. Joint effort with @bayraktar_lab @sangerinstitute @NosedaLab @imperialcollege @m_hemberg @UKCICstudy
collabs. Check out 🧵doi.org/10.1101/2023.12.20.5…
Noseda_lab retweeted
Today is #WorldHeartDay!
These risk factors put your heart ♥️ at risk:
❗️Unhealthy diet
❗️Drinking too much alcohol
❗️Tobacco
❗️Air pollution
❗️Not moving enough
Noseda_lab retweeted
And also our paper, out in @nature: nature.com/articles/s41586-0…
A big thanks to everyone who made it possible! @sangerinstitute @imperial @thebhf @dzhk_germany @humancellatlas @teichlab @NosedaLab @kazukane @JamesCranley Krzysztof Polański
Noseda_lab retweeted
Where can you learn all about it? Check our technology page on the @sangerinstitute website, with additional information on our tool
#academictwitter #bioinformatics
sanger.ac.uk/technology/drug…
Noseda_lab retweeted
Why do we love it?
➡️Because it improves how new (and old) treatments are evaluated and how they affect organs and tissues.
➡️It allows for checking specific cell targets of drugs in organs of the body where single cell data are available.
Noseda_lab retweeted
…predict those from new drugs. It also enables to perform in silico 🖥️ drug screening, as well as to identify new medicines that target specific cells, introducing a new level of precision 🎯.
Noseda_lab retweeted
What are the advantages?
To identify specific cellular targets of bioactive molecules with drug properties based on single-cell RNA-seq data. This can potentially reveal hidden mechanisms of action on specific cell types to understand known side effects, and... (more on next one)
Noseda_lab retweeted
Once the drug scores are calculated, you can then find cells which are targeted by drugs of interest or find drugs💊 which target cells of interest, such as heart pacemaker cells in the published paper.
Noseda_lab retweeted
How does it work?
Drugs & target molecules can be queried and filtered based on:
⏺️Activity of drug-target interaction
💊Drug categories
🩺Clinical trial phase
🧫Classes of molecular targets.
Noseda_lab retweeted
Our tool takes pairs of drugs and their target molecules from drug databases such as @EMBL-EBI’s ChEMBL database. It leverages single-cell profiles and the database’s 19 M drug-target interactions.
ebi.ac.uk/chembl/
Noseda_lab retweeted
Drug2cell allows us to make mechanistic inferences, including drugs’ side effects such as those impacting heart rate ❤️. It stems from a collaboration from @Sangerinstitute @imperialcollege and others.
Noseda_lab retweeted
We are excited to announce a new computational tool, drug2cell, published in @nature. This tool can provide insights into the precise cellular targets of drugs.
Want to know all about it? Keep reading!
#genomictool #sangerinnovation
Noseda_lab retweeted
Thrilled to see our paper published @Nature.
nature.com/articles/s41586-0…
This is a great teamwork with @JamesCranley who is my master of human heart!
Happy to be as a member of @teichlab, and thank you to Sarah, @NosedaMichela, and everyone who is around us.
Noseda_lab retweeted
Thank you very much to everyone who has attended the #HCA2023GM meeting. It’s been wonderful to connect with everyone and we really hope you’ve enjoyed it.



















