Biophysicist at @IBECbarcelona, @unibarcelona.
Barcelona, Espanya
Joined October 2019
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Pere Roca-Cusachs retweeted
🧵🧬 How cells decide when to react could shape future treatments for cancer and fibrosis
A recent study from IBEC and King’s College London reveals a surprising insight: cells don’t just detect mechanical forces, they also measure how long those forces last before reacting.
I never intended this account to be about politics but there is a limit to everything. So, a bit late, but finally moving to Bluesky. Please check @pcusachs.bsky.social for updates on our lab, with the first one coming today!
Pere Roca-Cusachs retweeted
#PCBCommunity | An @IBECBarcelona-led study reveales how #mesenchymal_stem_cells respond to viscosity in their environment
📝@NatureComms
The findings could revolutionise the #biomaterials design for #regenerativemedicine ▶️bit.ly/4eyqeTy
@ManuelMime @ribonucleico3 @MarianaAG0 @PCusachs @UniBarcelona @EvaBEstaje @DalbyMatthew @marcocantini24 @finbeag @theglasgowcemi
Our work on a new technique we call 3D micropatterned traction force microscopy (3D-μTFM) is now out:
onlinelibrary.wiley.com/doi/…
The result of hard, systematic, and precision work over the years by Laura Faure (experimental) and Manu Gómez (computational), in a joint effort between the labs of
@XavierTrepat
and our own. In collaboration with the labs of Marino Arroyo (UPC) and Elena Martínez (IBEC).
Pere Roca-Cusachs retweeted
Through 3D micropatterned traction force microscopy, scientists can now measure the forces cells exert on their environment.
@PCusachs and team used it to show how epithelial cells switch between contracting and extending as their volume changes.
👉 ow.ly/kMps50TSMf1
Pere Roca-Cusachs retweeted
.@i_GraneroMoya, @AndreuIon, @PCusachs & colleagues find that nucleocytoplasmic transport senses mechanical forces independently of cell density in cell monolayers. #OpenAccess #ReadAndPublish
Highlight: journals.biologists.com/jcs/…
Article: journals.biologists.com/jcs/…
ALT Fluorescent image showing lower YAP nuclear localisation high-density cells
Pere Roca-Cusachs retweeted
Looking for a summer read?🏖️🌞📄 You're in luck 😂. Our paper on optogenetic leader cells is out @NaturePhysics. We found a force-velocity relation for collective cell migration. Experiments by @LeoneRossetti, theory by @ricardalert. @IBECBarcelona
rdcu.be/dQDmM
Here is our new pre-print on a new technique we call 3D micropatterned traction force microscopy (3D-μTFM):
biorxiv.org/content/10.1101/…
The result of hard, systematic, and precision work over the years by Laura Faure (experimental) and Manu Gómez (computational), in a joint effort between the labs of @XavierTrepat and our own. In collaboration with the labs of Marino Arroyo (UPC) and Elena Martínez (IBEC).
With a bit of delay in announcing it, here is our new preprint on the role of force in the loss of naïve pluripotency:
biorxiv.org/content/10.1101/…
We show that forces increase during, and are required for, naïve pluripotency loss. This is mediated by GSK3 signalling. As a teaser, here is a naive pluripotency marker (Rex1-GFP, left), and traction forces (right) for a cell colony losing pluripotency (bottom) or not (top)
Painstaking, thorough, beautiful work by Srivatsava Viswanadha,recent Ph.D. graduate in my lab. Work co-directed between @ZanettaKechagia and myself, In collaboration with @KevinChalut and @XavierTrepat labs, with contributions by Manu Gómez, @celinelabo , and @valeria_ventur.