So finally, I get this photo opportunity with one incredible, inspiring and yet very humble Prof Carlos Parra- Herran @ Bagp 21st annual mtg
#gynpath
What’s new in WHO 2025 ?
Ahead of the 6th edition -
Key note lecture by Prof Glenn McCluggage
BAGP 21st annual meeting , Belfast
@BAGPGynPath @ISGynP #gynpath
Let’s not forget why we are doing what we are doing !!
Impactful talks on ‘ patient oriented pathology reporting ‘ by Prof Raji Ganesan and Prof Joe Rabban . @BAGPGynPath @ISGynP
Bagp 21st annual mtg Belfast
Dr Richard Wong on navigating the landscape of mixed carcinomas showing the heterologous morphology and immunoprofile . @BAGPGynPath @ISGynP #gynpath
This was another case that I came across a while ago, which shows pleomorphic CIN3. There was no invasion in multiple levels examined.
Pleomorphic CIN. This is just a LG CIN showing striking pleomorphism of basal cells.
Limited studies, but not associated with aggressive behaviour and may even represent a degenerative change.
Can be confused for early stromal invasion when cross cut.
#pathtwitter #gynpath
Prophylactic hysterectomy for LS. All benign. But saw this in one of the sections. This couldn't be fat. Could it? Have you ever come across this? #gynpath @Dramanyhassany1 @slusagar @kis_lorand @GbGynae @OBGYNPATH @DrSwatiBhardwaj @DrEstherAdler @DrGeeONE @TristanRutland7
F/50ish vaginal polyp. p16 negative. GATA3 positive in squamous, PSA negative. Do we have a name for this? Would you call it a tubulo-squamous polyp, or does the dominant glandular component speak against it?
#pathtwitter #Gynpath
Most impressive p53 that I have ever seen! (first image)
And a negative p16! (second image)
So a great example of HPV-independent VIN mimicking HPV-associated VIN.
There is a hint of stromal hyalinisation in the first HE image and some lichenoid inflammation as soft hints!
F/64 ish
Vulval biopsy
These HE images are enough to make the diagnosis!
HPV-A HSIL/VIN 3. Right?
Check the next tweet/post in the thread.
It may surprise you!
#pathtwitter #gynpath #frcpath #histopathology
2/3 The first image is PAX8 and the second one CK7. ER negative.
So reduced markers of differentiation in the undiff component. MMR intact. Neuroendocrine markers negative but wouldn't have surprised me if there was focal positivity as @kis_lorand says.
F 60ish. 2 cm polypoid uterine tumour.
Myoinvasion present.
What are your potential differential diagnoses, and which tests would you like to perform?
#pathtwitter #Gynpath #frcpath #bagp
Here is the reference to what I believe is the first report of this variant by Dr. Scully and Dr young. 3/3
