@PenengoLab

We investigate the role of the ubiquitin and the interferon/ISG15 system in maintening genome stability in response to different types of stress

 IMCR, Zurich, Switzerland
imcr.uzh.ch/en/research/penengo
Joined February 2023
  • Tweets28
  • Following174
  • Followers192
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Replying to @SylvieNoorderm1
congratulations to you Sylvie and to the whole group!!!! I look forward to having Anne in my lab soon!!!
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Replying to @auracarreiralab @UZH_en
Aura, thank you so much for accepting our invitation and giving an amazing talk!!!
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Lorenza Penengo Lab retweeted
Sidrit Uruci (Sid)@UruciSidrit23 Jan 2024
So exciting to see this amazing story out!! Glad I could be of help 😁 Huge shout-out to all authors involved 🎉🎉 A highly recommended read for all DSBs and DNA repair aficionaf@s!!
Sylvie Noordermeer@SylvieNoorderm123 Jan 2024
It is online! The first paper of the Noordermeer lab. Of course, this wasn't possible without the help of many others (see thread for more details). Congratulations to first authors @BertKooij, Anne Schreuder and @pavani_raphael. sciencedirect.com/science/ar… 1/8
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Lorenza Penengo Lab retweeted
Hubrecht Institute@_Hubrecht9 Nov 2023
Researchers from the group of @FMattiroli developed a new fluorescence-based assay and used this to identify ANP32B as the histone chaperone responsible for the histone macroH2A. First author @IMandemaker tells all about it here! hubrecht.eu/histones-and-cha…
Microscopy image of human cells stained for macroH2A and DNA.

ALT Microscopy image of human cells stained for macroH2A and DNA.

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Lorenza Penengo Lab retweeted
Arnab Ray Chaudhuri@Arnab_RC17 Nov 2023
The final countdown has begun… a week more for the closing of registrations… please register soon as only a few more slots are left🔥👇
Arnab Ray Chaudhuri@Arnab_RC131 Oct 2023
Just a few more days to go for the registration deadline- “EMBO workshop on evolution and diversity of the DNA damage response” meetings.embo.org/event/24-d… multiple short talks, & waivers available! 🧬Don’t miss this amazing opportunity to meet with world leaders & journal editors.☄️

Evolution and diversity of the DNA damage response

To cope with the threat of genome instability, cells have evolved an intricate network of mechanisms ranging from cell cycle checkpoints to specialized DNA repair pathways, and collectively known as …

meetings.embo.org
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Lorenza Penengo Lab retweeted
Fabrizio d'Adda di Fagagna@FdAdF667 Nov 2023
Happy to share our recent publication identifying a vulnerability in ALT #cancer cells that can be targeted by #telomeric #antisenseoligonucleotides #ASO against #ncRNA induced by #telomere dysfunction. nature.com/articles/s41467-0…

Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs

Nature Communications - ALT cells use an alternative lengthening mechanism of telomeres and bear telomeric DNA damage with increased levels of damage-induced long non-coding RNA. Here the AUs show...

nature.com
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Replying to @DibitettoDiego
Good luck Diego!!! I wish you all the best!!!!
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Replying to @Tanejalab @oncodeinstitute @ErasmusMC
Congratulations Nitika!!!
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Lorenza Penengo Lab retweeted
Aga Gambus@AgaGambus20 Oct 2023
We are looking for DNA replication enthusiast to join our group as a postdoctoral researcher. If you are into biochemistry, cell biology, structural biology in replication and damage, please get in touch, or apply - the link below. Closing date 9th November. RT pls
Cancer and Genomic Sciences@IcgsUob20 Oct 2023
📢Research Fellow wanted to create & contribute to the creation of knowledge by undertaking research specified by BBSRC research grant awarded to @AgaGambus to investigate function of DONSON during DNA replication initiation. shorturl.at/ghnGX
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Replying to @Emlecona @uddipta_biswas @RFreireLab @Arnab_RC1
thank you!!!!
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Replying to @APanagopoulos_ @uddipta_biswas @RFreireLab @Arnab_RC1
thank you!!!!
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Replying to @Arnab_RC1 @uddipta_biswas @RFreireLab
thank you!!!!
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Replying to @AgaGambus @uddipta_biswas @RFreireLab @Arnab_RC1
thank you!!!!
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Replying to @Tanejalab
thank you!!!!
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thank you!!!!
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Replying to @uddipta_biswas @RFreireLab @Arnab_RC1
thank you!!!!
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Replying to @polosimona1 @uddipta_biswas @RFreireLab @Arnab_RC1
grazieeee!!!!
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ONLINE NOW our story on the role of interferon/ISG15 in BRCA contexts! Congratulations to Ramona Moro, @uddipta_biswas, and all the co-authors! A great collaborative effort with Shyam Sharan, @RFreireLab and @Arnab_RC1. nature.com/articles/s41467-0… Thrilled to hear your feedback!

Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15

Nature Communications - Here the authors show that the basal activation of the interferon/ISG15 pathway is required for the stability of nascent DNA during replication and its upregulation promotes...

nature.com
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Replying to @Mandy98045385 @CSHL
yes that's correct! 2 hr of treatment, 46 hr of chase. Happy you like the paper!
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Lorenza Penengo Lab retweeted
Raimundo Freire@RFreireLab28 Mar 2023
Excited to announce our new paper by @EsperanzaHC_ in @NAR_Open, showing a new role for ATXN3 in regulating chromatin structure by controlling the subcellular localization of HDAC3 and thereby giving insight into the molecular basis of SCA3. doi.org/10.1093/nar/gkad212

ATXN3 controls DNA replication and transcription by regulating chromatin structure

Abstract. The deubiquitinating enzyme Ataxin-3 (ATXN3) contains a polyglutamine (PolyQ) region, the expansion of which causes spinocerebellar ataxia type-3

academic.oup.com
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