@PerrySpratt

Program Director @RegelTherapeutics. Former scientist @Maplightrx and grad student @UCSF with @neurobender

 San Francisco
Joined June 2011
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Hello twitter! My latest #SCN2A paper was posted to @bioRxiv last week! Below is a quick summary of the key findings of the preprint biorxiv.org/content/10.1101/… 1/13

Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells

Loss-of-function variants in the gene SCN2A , which encodes the sodium channel NaV1.2, are strongly associated with autism spectrum disorder and intellectual disability. An estimated 20-30% of...

biorxiv.org
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This paper is the product of the hard work of @roybensh, Atehsa Sahagun, Caroline Keeshen, Stephan Sanders, and @neurobender, and is motivated by the many children and families of @FamilieSCN2A who have provided us with continuing inspiration over the years. 12/13
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And finally, this project was made possible through the generous funding of @SFARIorg and by @NSERC_CRSNG who supported my PhD training @UCSF. Thank you for reading! 13/13
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Excited to share this work! Check out @KaruneshGanguly’s thread for summary!
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Perry Spratt retweeted
Roy Ben-Shalom@roybensh10 Jun 2020
Unless you engage directly with eliminating racism, you are perpetuating it. This moment calls for profound and meaningful change. #ShutDownAcademia and #ShutDownSTEM is the time to educate and define a detailed plan of action to carry forward. from: shutdownstem.com/
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NeuroGPU, software for NEURON modeling in GPU-based hardware biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Perry Spratt retweeted
BrainPost@brainpostco3 Jul 2019
Dendritic Excitability and Synaptic Function Are Impaired with Haploinsufficiency of the #Autism-Associated Gene Scn2a This week in @neurocellpress by @NeuroBender, @PerrySpratt, and @roybensch @brainpostco's scientific summary by @McFarlanAmanda 👇brainpost.co/weekly-brainpos…
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The first paper from my PhD is now online @NeuroCellPress! Big thanks to @roybensh and all of @NeuroBender’s lab for all the hard work that went in to it. cell.com/neuron/fulltext/S08… Read the thread from our @bioRxiv preprint to learn more xitter.cf/PerrySpratt/status/101…

The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the...

Haploinsufficiency in the gene SCN2A, which encodes the sodium channel NaV1.2, has strong autism association. Spratt et al. show that Scn2a contributes to dendritic excitability in mature neocortical...

cell.com
Perry Spratt@PerrySpratt11 Jul 2018
My first paper from @UCSF has just been posted up on @bioRxiv! Below is a short summary of what we found: xitter.cf/biorxiv_neursci/status…
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Meanwhile, in France
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