Jozef Stefan Institute
Joined June 2012
Excited to share our new paper in @FEBSJournal! With @OndrejKuda & @FedorovaLab we show how LDs reshape the lipidome of PUFA-exposed cells & shift function within the same cell, revealing a context-dependent role in ferroptosis. Congrats Ana & @Lejaperne! shorturl.at/TyRl1
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Toni Petan retweeted
Save the date! 🔥 The 2027 FASEB Science Research Conference on Ferroptosis: From Mechanism to Medicine is coming to Denver, July 12–15! We are excited to bring the ferroptosis community together again. Experts and newcomers welcome! Please help spread the word! More info soon!
🤖 Made with AI
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Toni Petan retweeted
New preprint! We find that fatty acid double-bond geometry alters their metabolic fate and ferroptosis sensitivity. Trans fatty acids are metabolized differently from their cis counterparts, reshaping membrane phospholipids and ferroptosis sensitivity. biorxiv.org/content/10.64898…
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Toni Petan retweeted
Thrilled to share this #lipidtime story in @JCellBiol where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!
How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. hubs.la/Q04mQjrC0 @basktastic @weillinstitute @CornellChem
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Toni Petan retweeted
How does a cell remodel the ER membrane into a lipid droplet? Excited to share our new preprint. We find that regulated opening of the seipin ring defines a functional ER–lipid droplet interface — and identify SMLR1 as a regulator of this transition. biorxiv.org/content/10.64898…
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A new review from the lab on #LipidDroplet heterogeneity in Current Opinion in Cell Biology. Big thanks to Philippe Chavrier and Chris Fromme for organizing an exciting #Membrane Trafficking special issue! sciencedirect.com/science/ar…
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Toni Petan retweeted
The danger of reasoning by analogy: "The behavior of things on a very tiny scale is simply different. (Atoms) do not behave just like particles. The do not behave just like waves. Atoms do not behave like weights hanging on a spring and oscillating. Nor do they behave like miniature representations of the solar system with little planets going around in orbit. Nor does it appear to be like a cloud or fog of some sort surrounding the nucleus. It behaves like nothing you've seen before." Likewise, the cell is not a deterministic machine or factory. I think I can safely say that nobody understands the cell.
“I think I can safely say that nobody understands quantum mechanics.” - Richard Feynman (1964 Cornell Lecture)
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Toni Petan retweeted
Artificial intelligence is not replacing human intuition in maths and physics, but reimagining how questions are asked, explored and understood go.nature.com/4aESYuz
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Marjana Ndoci, @DeshwalSoni et al. show that #mitochondria prioritize survival over safety: when resources are low, they stop exporting Coenzyme Q to keep respiration running, at the cost of antioxidant protection. hubs.la/Q04kwgfH0 #CellMetabolism #Organelles
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DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function dlvr.it/TSr75k
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Toni Petan retweeted
Please re-post! Time is almost up to register for the 2026 FASEB Lipid Droplet Meeting. Abstracts are due May 31, 2026. See link below, and join us for an amazing SRC lipid meeting July 26-30! #LipidSRC events.faseb.org/event/Lipid…
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📖FOS New Mini-Review! “On the lethal mechanism of class III ferroptosis inducers” by Prof. Scott J. Dixon from @Stanford. Check to see why FIN56 causes ferroptosis but its analogs don’t. 🔗: sciexplor.com/fos/articles/f… #ferroptosis #Science #academic #cell
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Fasting opens a metabolic window that favors anti-tumor immunity dlvr.it/TSWY8J
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Toni Petan retweeted
Great to see this Spotlight article in Trends in Cell Biology highlighting our recent identification of a lipid droplet quality control pathway in which FSP1 protects PUFA-rich neutral lipids from peroxidation, thereby suppressing ferroptosis. cell.com/trends/cell-biology…
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You do not want to miss the 2026 FASEB #LipidDroplet conference! Abstracts are due May 31. Travel awards are available for trainees 👇
Summer is approaching & so is the 2026 Lipid Droplets: From Mechanisms to Disease FASEB SRC (July 26-30 in Scottsdale, AZ)! Interested in lipids? Join this amazing summer research conference! Abstracts due May 31, Early registration June 14. events.faseb.org/event/Lipid…
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