@PhysRep: #Acetazolamide, an inhibitor of carbonic anhydrase that can induce arteriolar #vasodilation, is shown in this pilot study of acute #braininjury patients to increase brain #oxygenation and #intracranial #pressure. doi.org/10.14814/phy2.70159 @Hypoxia @CerebralVasculature

@PhysRep: Hearts of #pyruvatekinase M2 KO mice show increased oxidative stress, #inflammation and #fibrosis after #myocardial #infarction, implicating a protective role of #PKM2. doi.org/10.14814/phy2.70193 @Cardiovascular

@PhysRep: In this new paper, #thoracic load carriage in hypoxic conditions to mimic high #altitude is shown to increase physiological strain and interfere with compensatory responses to #hypoxia in healthy males. doi.org/10.14814/phy2.70197 @Respiratory #MuscleFatigue #Hemodynamics

@PhysRep: This new report shows that regulation of miRNA-1, a #skeletal #muscle specific #miR, is necessary for mechanical overload-induced muscle #hypertrophy in a mouse model doi.org/10.14814/phy2.70166 #myotwitter

@PhysRep: Congratulations to all the Authors of our most-read papers of 2024! @physoc @APSPhysiology @WileyBiomedical #Physiology

@PhysRep: Inter-organ #metabolism in @sepsis: this study in a porcine model of acute sepsis investigates the across-organ net fluxes of #gluconeogenesis substrates and the roles of #adipose and #muscle tissue breakdown doi.org/10.14814/phy2.70129

@PhysRep: This study on mice deleted for regulator of #Gprotein signaling proteins reports LV dilation and increased #myocardial #immune cells, without additional effect of sustained #βadrenergic receptor signaling doi.org/10.14814/phy2.70178 @Cardiovascular @Heart #CellSignalling

@PhysRep: New report on #cardiac, autonomic, #haemodynamic and #biomarker responses in trained men taking 2 Olympic distance, lab. based #duathlon, 7 days apart. Functional and biomarker changes were similar to after #triathlon. doi.org/10.14814/phy2.70154 @Cardiovascular @Exercise

@PhysRep: Studies on female hormonal responses to #exercise are limited. This report shows that a 30-min exercise #stress test leads to hormonal elevations in saliva and plasma of young healthy females. doi.org/10.14814/phy2.70168 #WomensHealth @Physiology @Endocrinology

@PhysRep: Studies on female hormonal responses to #exercise are limited. This report shows that a 30-min exercise #stress test leads to hormonal elevations in saliva and plasma of young healthy females. doi.org/10.14814/phy2.70168 #WomensHealth @Physiology @Endocrinology

@PhysRep: This study sets up a new methodology to induce #Cardiac #alternans like contraction status in vitro in human-induced pluripotent #stemcell derived #cardiomyocytes doi.org/10.14814/phy2.70152 @Cardiovascular @iPSC @CellPhysiology

@PhysRep: The editors thank all authors, reviewers, editors, readers and journal staff for their support of Physiological Reports in 2024. Wishing All in our community Happy Holidays and great research in 2025! @APSPhysiology @physoc @WileyBiomedical @WileyNeuro #Physiology

@PhysRep: Our Editor’s choice paper from November is "Force monitoring reveals single trial dynamics of motor control in a stop signal task" by Surabhi Ramawat and colleagues. Read the paper at: doi.org/10.14814/phy2.70127 #Biomechanics

@PhysRep: Also now posting on BlueSky! @physrep.bsky.social @physoc.bsky.social @ThePhysSoc @APSPhysiology @WileyBiomedical

@PhysRep: This study examines how #hypercholanemia disturbs #pregnancy-related @adipose tissue expansion and mRNA expression in late gestation in mice, with implications for #intrahepatic #cholestasis of @pregnancy doi.org/10.14814/phy2.70141

@PhysRep: This study in a porcine model compares unilateral and bilateral @RenalArtery #stenosis conditions to investigate effects on #Renal pressure-flow relationship and #renin activation doi.org/10.14814/phy2.70082

@physrep: New study comparing #physiological responses of healthy adults to computer-based cognitive or #motor-cognitive training shows motor-cognitive SKILLCOURT to be adaptable for a broad range of #exercise intensities. doi.org/10.14814/phy2.70136 #Heartrate @Respiratory

@PhysRep: Our Call for Papers on Women’s Health Research in Basic and Translational @Physiology is now open! Find out more at physoc.onlinelibrary.wiley.c… @APSPhysiology @physoc @physoc.bsky.social @WileyBiomedical

@PhysRep: Study of effects of Fetal #growth #restriction on gene expression during #differentiation of perirenal #preadipocytes implicates target genes that may affect the risk of male FGR for obesity in adulthood. doi.org/10.14814/phy2.70143 #epigenetics @developmentalbiology

@physrep.bsky.social @APSPhysiology @physoc @physoc.bsky.social @WileyBiomedical @WileyNeuro