🚨 BREAKING NEWS A major milestone for Pi-Cardia and the future of complex TAVR We are excited to announce a strategic investment by Medtronic in Pi-Cardia, marking a significant milestone in our mission to make leaflet modification a standard part of complex TAVR and expanding access to ShortCut, the first FDA-cleared leaflet modification technology designed to enable valve-in-valve TAVR procedures in patients at risk of coronary obstruction. We are grateful to our team, investors, clinical partners, physicians and everyone who has supported Pi-Cardia on this journey. We look forward to this next chapter as we work together to accelerate the adoption of ShortCut and continue advancing the future of leaflet modification. We would like to extend a sincere thanks to our investors, including Sofinnova Partners, Sprig Equity, and Jacques Séguin, whose vision, support, and commitment have helped advance Pi-Cardia's mission. Read the full press release: prnewswire.com/news-releases… @Medtronic @MDT_StructHeart @MDTVascular @Eegg34 @EyalKolka @jssoskin @SofinnovaVC @SpringEquity @jacques_seguin #PiCardia #Medtronic #TAVR #StructuralHeart #MedTech #Cardiology #Innovation

💡 Advancing real-world experience with ShortCut in complex ViV-TAVR patients The largest published commercial experience with ShortCut provides real-world evidence from 150 patients treated across 28 U.S. centers, including >50% first-time users. Key findings include: ✅ >99% leaflet-splitting success, including 57% dual leaflets ✅ >36% of patients were treated for failed TAV ✅ >87% of patients were high risk for acute coronary compromise Despite treating a highly challenging patient population, these results support the feasibility, reproducibility, and safety of ShortCut mechanical leaflet modification to help prevent coronary obstruction during complex ViV procedures. 💚A sincere thanks the investigators, authors, advisors, and participating centers for their collaboration and contributions to this important publication. 📖 Read more at: sciencedirect.com/science/ar… @JACCJournals @RajMakkar @aakriti_15 @IgnacioInglessis-Azuaje @CurtissStinis, @PradeepYadavMD @VinodThourani @StanleyChetcuti @MatthewSummers @VivekPatel @BassemChehab @patelapurva @GilbertTangMD @KHERA_MD @MichaelRinaldi @tjsimard @JeffreySouthard @BenjaminStripe @whisenant_brian @KeithAllen @YosephRozenman @DvirDanny @CarlosSanchez, M.D. @PopmaJeffrey @MartyBLeon @PhilGenereuxMD #JACC #NYValves2026 #NYValves #PiCardia #ShortCut #AorticValve #AorticStenosis #Cardiology #complexTAVR #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #MedicalInnovation #medtech #Partnership #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #VIV #ValveinValve #ViVTAVR #StructuralHeart

✨Fantastic week at #NYValves2026 It was exciting to see the growing momentum behind ShortCut, highlighted by several activities: 🫀 A highly engaging Scientific Advisory Board meeting with some of the world’s leading structural heart experts. 📖 The simultaneous publication of the ShortCut Commercial Experience in JACC, featuring outcomes from 150 patients, alongside its presentation by Dr. Raj Makkar. 🎬 A recorded live case in a patient with a challenging anatomy that was successfully treated with ShortCut presented by Dr. Pradeep Yadav and Dr. Vinod Thourani 🎤 A dedicated ShortCut session, where key operators shared compelling real-world case experiences. 📈 A ShortCut program update by Dr. Danny Dvir, outlining the continued progress and future direction of the technology. 👏 A sincere thank you to our advisors, investigators, physicians, speakers, and colleagues for your continued support! #JACC #NYValves2026 #NYValves #PiCardia #ShortCut #AorticValve #AorticStenosis #Cardiology #complexTAVR #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #MedicalInnovation #medtech #Partnership #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #VIV #ValveinValve #ViVTAVR #StructuralHeart @DvirDanny @MichaelGrossman @CurtissStinis @NilayPatel @HaleemaNawaz @AshwiniKerkar @AndrewMorse @RajMakkar @AakritiGupta, @PradeepYadavMD @VinodThourani @OliviaHulme @JeffreyPopma @MartinBLeon @PhilGenereuxMD @TariqAhmad @KeithAllen @StanleyChetcuti @IgnacioIglessis @VijayIyer @patelapurva @MichaelRinaldi @benjaminseguy @MatthewSherwood @MatthewSummers @GilbertTangMD

📢 Publication Release & Simultaneous Presentation at #NYValves2026 “Real-World Outcomes of Dedicated Leaflet Modification for Bioprosthetic Valve-in-Valve TAVR: A 150 Patient Commercial Experience” was publication in in JACC: Cardiovascular Interventions and simultaneously presented by Dr. Raj Makkar at NY Valves. This experience demonstrates the vital role of ShortCut leaflet modification in addressing one of the most fatal complications of ViV TAVR, coronary obstruction, in patients with complex anatomy. 📝Key Highlights: • 150 consecutive patients treated across 28 U.S. centers • 99.3% procedural leaflet splitting success • More than 1/3 of patients underwent treatment for a failed TAVR A sincere thank you to Dr. Raj Makkar, all co-authors, and participating investigators who contributed to this important work 💚 jacc.org/doi/10.1016/j.jcin.… #JACC #NYValves2026 #NYValves #PiCardia #ShortCut #AorticValve #AorticStenosis #Cardiology #complexTAVR #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #MedicalInnovation #medtech #Partnership #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #VIV #ValveinValve #ViVTAVR #StructuralHeart

💡Attending #NYValves2026? Join us for the ShortCut Leaflet Modification Sessions and discover how mechanical leaflet modification may help expand treatment options for patients undergoing complex TAVR procedures. 🫀 These interactive sessions will feature expert discussions, clinical experience, and practical insights into the evolving role of leaflet modification in structural heart interventions. We'll explore how innovative approaches can help address challenging anatomies and contribute to the lifetime management of patients with valve disease. 👋 We look forward to seeing you there! #NYValves2026 #NYValves #PiCardia #ShortCut #AorticValve #AorticStenosis #Cardiology #complexTAVR #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #MedicalInnovation #medtech #Partnership #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #VIV #ValveinValve #ViVTAVR #StructuralHeart

🚀 Don't miss this Late-Breaking Innovation presentation at hashtag#NYValves2026 Dr. Raj Makkar will present: “Real-World Outcomes of the ShortCut Device for Leaflet Modification Prior to ViV TAVR – Early Commercial Experience” As ViV procedures continue to grow, addressing coronary obstruction risk while optimizing outcomes remains a key challenge. Dr. Makkar will present early commercial and real-world experience with the ShortCut™ device, highlighting its role in leaflet modification prior to ViV TAVR and its potential to expand treatment options for Complex TAVR patients with failed bioprosthetic valves. 📅 Thursday, June 25 🕐1:45–2:45 PM EDT 📍 Heart Team Arena | Room 406 | Level 4 #NYValves2026 #NYValves #PiCardia #ShortCut #AorticValve #AorticStenosis #Cardiology #complexTAVR #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #MedicalInnovation #medtech #Partnership #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #VIV #ValveinValve #ViVTAVR #StructuralHeart

⛰️ ShortCut Expands Access to Innovation for UVM Patients Across VT and Upstate NY 🎉 Congratulations to Drs. Dauerman, Gupta, Lahoud, Gilliland, Brickshwana and the entire valve team at the University of Vermont Medical Center on the successful integration of ShortCut leaflet modification into their structural heart program. 🫀 The team's first two #ShortCut cases highlight the unique complexities that can accompany redo valve interventions. The first patient presented with a failing surgical valve due to aortic stenosis, with a prior Dacron graft and both coronary cusps at risk of obstruction and sinus sequestration. A dual leaflet split was performed to facilitate a safe #VIV procedure. The second patient also presented with a failing surgical valve due to #AS and required a single split of the right cusp to mitigate coronary obstruction risk and enable a safe TAV-in-SAV procedure. 🙏 We are honored to support the #UVM team as they continue to deliver innovative, compassionate care to #complexTAVR patients across the rural communities they serve. Harold Dauerman Tanush Gupta Rony Lahoud Tom Gilliland Adipong Brickshawana Jamie Carroll #UVM #UVMHealth #PiCardia #ShortCut #AorticValve #AorticStenosis #BAV #bicuspid #Cardiology #complexTAVR #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagementofAS #MedicalInnovation #medtech #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #VIV #ValveinValve

💓 ShortCut Expands to More Central PA Patients Across the Geisinger Health System 🙌 Congratulations to Drs. Arav Jhand, Shikhar Agarwal and the entire structural heart team at Geisinger Danville Medical Center on launching their #ShortCut leaflet modification program. 🫀The team performed left coronary leaflet splits to enable the safe implantation of MDT Evolut FX+ valves in two patients who were at high risk for coronary obstruction. The first patient underwent a TAV-in-TAV procedure to replace her failing #SAPIEN3 transcatheter valve due to aortic stenosis; the other underwent a TAV-in-SAV procedure to replace his failing Trifecta valve due to aortic regurgitation. 🦾Bravo on a strong start team! Looking forward to helping you make better health possible for your #complexTAVR patients in need of innovative options. #Geisinger #GHVI #PiCardia #ShortCut #AorticValve #AorticStenosis #BAV #bicuspid #Cardiology #complexTAVR #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #MedicalInnovation #medtech #Partnership #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #VIV #ValveinValve

💫 ShortCut Shows Up for SoCal Patients Supported by Leading Heart Team at Los Robles 🎉 Congratulations to Drs. Saibal Kar, Greg Fontana and the structural heart team at Los Robles Health System on the introduction of #ShortCut leaflet modification to enhance the world-class care provided to its complex valve disease patients. 🫀 The team treated an 86 year-old patient whose MagnaEase surgical valve was failing due to aortic regurgitation and who was at high risk for coronary obstruction. After an efficient split of the patient’s left coronary cusp, the team effortlessly delivered an #Evolut THV and excellent outcome to this valve-in-valve patient. 🤝 We are honored to work with your team to offer a new way to treat #complexTAVR patients with the most advanced heart care available today. Here’s to improving more patients' lives together, one heart at a time! #HCAHealthcare #LosRoblesHealthSystem #LosRoblesHospital #PiCardia #ShortCut #complexTAVR #TAVR #VIV #AorticValve #AorticStenosis #BAV #bicuspid #Cardiology #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #MedicalInnovation #medtech #Partnership #startuphealth #StructuralHeart #TAVI #THV #transcatheter #valvefailure #ValveinValve

The future of Complex TAVI ViV interventions is on the rise.   At #EuroPCR2026, Dr. Didier Tchétché shared interesting insights during his presentation on “Forecasting TAV-in-Valve Procedural Volume in Europe” — highlighting how the structural heart landscape is rapidly evolving.   Key takeaways: 🟢 ViV procedures currently represent ~5% of the TAVI market and is expected to grow to 12% by 2035. 🟢 TAV-in-TAV procedures are projected to overtake the TAV-in-SAV by 2028. 🟢 Leaflet modification will become increasingly critical to enable safe and effective interventions for patients requiring multiple valve procedures throughout their lifetime.   Thank you, Dr. Didier Tchétché, for sharing these valuable insights and helping shape the conversation around the future of structural heart interventions 📗 💚 @didier_tchetche @PCRonline #euroPCR #PiCardia #AorticValve #AorticStenosis #complexTAVR #coronaryobstruction #coronaryaccess #heartvalvefailure #Innovation #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #medtech #ShortCut #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #ValveInValve #VIV #valvefailure

💪🏻Off to a strong start at #EuroPCR2026! In his presentation, “Optimising outcomes for complex TAVI valve-in-valve cases with leaflet modification and AI-powered planning,” Dr. Matt Summers highlighted the role of ShortCut leaflet modification in a complex TAVR case involving a failed surgical valve requiring reintervention. In this high-risk patient, ShortCut played a critical role in reducing the risk of coronary obstruction and enabled safe TAV-in-SAV implantation of a 23 mm self-expanding THV. Dr. Summers also emphasized the growing importance of advanced decision-support tools, adjunctive techniques, and efficient leaflet modification strategies in addressing the increasing complexity of the expanding TAVI ViV patient population. Thank you, Dr. Summers, for sharing your insights and experience💡💚 #euroPCR #PiCardia #AorticValve #AorticStenosis #complexTAVR #coronaryobstruction #coronaryaccess #heartvalvefailure #Innovation #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #medtech #ShortCut #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #ValveInValve #VIV #valvefailure

🌟ShortCut Joins the Best in Texas! 🎯Congratulations to Drs. Goel, Reardon, Aoun and Del Val, and the entire Houston Methodist structural heart team on another medical milestone with their first two hashtag#ShortCut leaflet modification cases. 🤝 We are thrilled to partner with you to deliver better options and outcomes to your hashtag#complexTAVR patients. Your commitment to leading the way in delivering the highest level of quality care to each patient is truly inspiring. #HoustonMethodist #DeBakeyHeartVascular #PiCardia #ShortCut #complexTAVR #VIV #AorticValve #AorticStenosis #BAV #bicuspid #Cardiology #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #MedicalInnovation #medtech #Partnership #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #ValveinValve

🚀 Rhode Island’s First Health System Performs First ShortCut Case 🎉 Congratulations to Drs. Paul Gordon, Marwan Saad, Anum Asif and the entire structural heart team at Brown University Health - Rhode Island Hospital on a strong start with ShortCut leaflet modification. 🫀 The team treated a 76-year-old woman whose Trifecta valve was failing due to aortic stenosis and who was at high risk for coronary obstruction. After an efficient dual leaflet split, a TAV-in-SAV procedure was safely completed, providing good flow to coronaries and an optimal result for this complex valve disease patient. 💚 Your commitment to innovation through collaboration truly sets your team apart. We look forward to working together to help more patients. Here's to a great start! #BrownUniversityHealth #RhodeIslandHospital #AorticValve #AorticStenosis #BAV #bicuspid #Cardiology #complexTAVR #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #MedicalInnovation #medtech #Partnership #PiCardia #ShortCut #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #ValveinValve #VIV

🚀 Another Barnes-Jewish Breakthrough with First ShortCut Case 🤝We’re thrilled to partner with Drs. Alan Zajarias, Tsuyoshi Kaneko, Nishath Quader and the Barnes-Jewish structural heart team to bring ShortCut leaflet modification to patients at high risk of coronary obstruction. 🫀 By performing a dual-leaflet split on a high-risk 71YO patient, the team prevented obstruction of both coronaries and safely delivered an hashtag#Edwards SAPIEN 3 Ultra Resilia implant with an excellent outcome. 🙏 Grateful for partners who successfully blend medical breakthroughs like hashtag#ShortCut with extraordinary patient care, so hashtag#complexTAVR patients can get back to living their best lives.💚 #AorticValve #AorticStenosis #BarnesJewish #BJCHealth #BAV #bicuspid #Cardiology #complexTAVR #HealthcareExcellence #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #mechanicallaceration #MedicalInnovation #medtech #Partnership #PiCardia #ShortCut #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #ValveinValve #VIV

🥇ShortCut First in Florida @ BayCare Morton Plant Hospital 🙌Congratulations to Drs. Joshua Rovin, Jayendrakumar Patel, and the dedicated structural heart team at BayCare Morton Plant Hospital on their first ShortCut case! 🫀Since the introduction of the #ShortCut device, the skilled Heart Team has treated multiple patients with failing TAV or SAV valves who were at risk coronary obstruction, enabling, safe, predictable valve-in-valve results for their #complexTAVR patients. 💚Bravo team #BayCare! Thank you for your shared commitment to excellence through innovation.🤝 #AorticValve #AorticStenosis #BayCare #bicuspid #BAV #complexTAVR #heartvalvefailure #Innovation #leafletlaceration #leafletmodification #leafletsplitting #mechanicallaceration #medtech #LifetimeManagement #LifetimeManagementofAS #PiCardia #ShortCut #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #ValveinValve #VIV

✨ShortCut Comes to Western NY 🦬 👏 Congratulations to Dr. Vijay Iyer and the entire structural heart team at Kaleida Health-Buffalo General Medical Center! 💙🩺The team successfully treated a 68YO female patient whose Magna valve was failing due to aortic stenosis. After a streamlined dual split of both left and right coronary cusps, they safely performed a #TAVR #VIV procedure and achieved an excellent patient outcome. 🫡We salute your relentless commitment to advancing medicine through complex valve treatment innovations like #ShortCut leaflet modification, and to providing excellence in all you do. Honored to work with your passionate team of experts. 💚 #AorticValve #AorticStenosis #bicuspid #BAV #complexTAVR #heartvalvefailure #Innovation #Kaleida #leafletlaceration #leafletmodification #leafletsplitting #LifetimeManagement #LifetimeManagementofAS #mechanicallaceration #medtech #PiCardia #ShortCut #startuphealth #StructuralHeart #TAVI #TAVR #THV #transcatheter #valvefailure #ValveinValve #VIV