@PopoMicro

Bacterial transposons; Tn7-like elements; CRISPR; 🇹🇼

Joined June 2018
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Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear genomes. We identified several families of independently evolved telomeric transposons. 1/7 biorxiv.org/content/10.1101/…

Telomeric transposons are pervasive in linear bacterial genomes

Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. While many bacteria also have linear chromosomes and plasmids, no...

biorxiv.org
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Excited to share our recent findings on Tn7 and its fascinating targeting mechanism, now published in Molecular Cell! 🧬🔬Check it out sciencedirect.com/science/ar…
Alba Guarne@alba_guarne3 Jun 2024
Happy to share that our last story on Tn7 is finally out. Another example of @shen_yao10 talent and a great collaboration with @JoePetersLab @MikePetassi Assembly of the Tn7 targeting complex by a regulated stepwise process sciencedirect.com/science/ar…
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Disclaimer: Photo was digitally edited to include @PopoMicro and @MachadoChacon who couldn't make the photo shot
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It was a pleasure working with @PopoMicro on this review of CRISPR-Cas associated transposons (CAST). Hopefully it gives a sense for the diversity of Tn7-like transposons and CRISPR systems that independently combined.go.shr.lc/444PwFh
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Replying to @PopoMicro @JoePetersLab @kellogg_liz @Nancy_Craig777 @alba_guarne @PhoebeARice @BarabasGroup @Christinahong9
Look what I found! Compliments of the talented @christinerbeck
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Transposons take over #CRISPR2022! @JoePetersLab @MariuszCzC @PhoebeARice
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Today we publish GeCoViz, an online tool for visualising the genomic neighbors of any prokaryotic gene in >12k reference genomes You only need to: 1.🔍Look by gene name/sequence, or by eggNOG/KEGG/Pfam code 2.🦠Choose your lineages of interest 3.Explore! gecoviz.cgmlab.org
Comparative Genomics and Metagenomics Lab@cgmlaboratory26 May 2022
Interested in exploring synteny conservation of prok. eggNOG/KEGG/PFAM groups or genes? Try GeCoViz: genomic context visualisation of prokaryotic genes from a functional and evolutionary perspective super work by @jbotas2 @alvarordr @Ginerorama doi.org/10.1093/nar/gkac367
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Very excited that our first paper from our collaboration with @kellogg_liz lab on Cas12k transposon target site selection is out! science.sciencemag.org/conte…
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The @kellogg_liz lab has posted its first pre-print! Here we continue our mechanistic studies of 'jumping genes' or transposases, in close collaboration with @JoePetersLab on CRISPR-associated transposases ( Type V-K CAST elements). biorxiv.org/content/10.1101/…

Structural basis for target-site selection in RNA-guided DNA transposition systems

CRISPR-associated transposition systems allow guide RNA-directed integration of a single DNA insertion in one orientation at a fixed distance from a programmable target sequence. We define the...

biorxiv.org
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