a community of computational protein engineers and modelers from both academia and industry an @openmsf project organized by @bahl_lab @nickpolizzi_ @sokrypton
Boston
Joined March 2020
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Boston Protein Design and Modeling Club retweeted
We signed a new research collaboration & license agreement! @AI_Proteins designs & optimizes de novo #miniproteins to multiple targets, & @AstellasUS does development & commercialization. This division of labor will help get new medicines to patients with the urgency they deserve
Astellas partners with Boston ‘miniproteins’ startup AI Proteins. Details in my exclusive for @endpts: - endpoints.news/exclusive-ast…
Boston Protein Design and Modeling Club retweeted
The Institute for Protein Design is hiring postdocs! 🧬
We design new proteins to tackle big challenges in medicine, sustainability & technology.
Interested in joining our interdisciplinary environment?
Learn more here: ipd.uw.edu/join-us/
Boston Protein Design and Modeling Club retweeted
I have postdoc positions available to lead two new exciting projects! One is on in situ protein sequencing (collab with Ed Boyden at MIT) and the other is on modeling cryptic pockets for drug discovery (collab with Scripps and MGH). Reach out if interested! Details below
Boston Protein Design and Modeling Club retweeted
Excited to share a preprint of my main PhD work in @nickpolizzi_'s lab - introducing LUCI-tag, a new orthogonal self-labeling protein tag based on K-Ras(G12C) and its covalent inhibitors! biorxiv.org/content/10.64898… (1/16)
Boston Protein Design and Modeling Club retweeted
Time to put that BindCraft2 multi targeting and custom loss implementation to good use!
Run now on AriaX, Tamarind, or via Google Colab and our Github:
In BC2 by Erik Mäeots
github.com/PacesaLab/BindCra…
BC1 version by Lennart Nickel and Paul Kittner:
github.com/martinpacesa/Bind…
We're launching Challenge 1 of the Anthropic x Adaptyv Protein Design Competition on @proteinbase: design a conditional binder to EGFR, a key cancer target.
The goal: bind EGFR under the acidic conditions of the tumor environment, but not at the normal pH around healthy cells. Moreover, the proteins must bind to both the human and the mouse variant of EGFR to support easier preclinical testing
Boston Protein Design and Modeling Club retweeted
Do you use self-labeling proteins (SLPs) like HaloTag and SNAP-tag? Then check out Jody's new preprint to learn about LUCI-tag! Jody built LUCI-tag starting from K-Ras(G12C), using protein design to erase K-Ras from biology 🤯!
Excited to share a preprint of my main PhD work in @nickpolizzi_'s lab - introducing LUCI-tag, a new orthogonal self-labeling protein tag based on K-Ras(G12C) and its covalent inhibitors! biorxiv.org/content/10.64898… (1/16)
Boston Protein Design and Modeling Club retweeted
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use.
We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition.
github.com/PacesaLab/BindCra…
Boston Protein Design and Modeling Club retweeted
We always strive for our work to substantially benefit the greater scientific community, and it's such a thrill every time it happens. A massive thank you to @Addgene for amplifying the impact of researchers everywhere!
🧵👇
Boston Protein Design and Modeling Club retweeted
Happening tonight! Come join in person or on zoom to hear Jeffrey talk about his work. Questions from zoom audience encouraged! bpdmc.org/schedule
Boston Protein Design and Modeling Club retweeted
The data, code, and detailed protocols are all available on github
github.com/aiproteins/high_t…
and all the plasmids are available on addgene
addgene.org/233685/
addgene.org/233686/
addgene.org/kits/bahl-sumo-p…
Boston Protein Design and Modeling Club retweeted
Peer-reviewed science that is verifiable and can be built upon remains essential, and we strongly believe in the value of sharing technology openly and freely with the community.
dx.doi.org/10.1002/pro.70746
Boston Protein Design and Modeling Club retweeted
Every protein designer knows that producing & testing designed proteins is a foundational capability for our field, & this is still pretty challenging for a lot of folks. This is why I'm delighted to share our work to make high-throughput protein production more accessible.
🧵👇
Boston Protein Design and Modeling Club retweeted
We have a new paper out on bioRxiv describing how to turn "static" small-molecule binders into dynamic shape changers! Short 🧵
biorxiv.org/content/10.64898…
Boston Protein Design and Modeling Club retweeted
We are looking for a lab manager starting from January 2027, you can find more information on our members page pacesalab.com/#members. We are also starting to look into hosting master students starting 2027.
Boston Protein Design and Modeling Club retweeted
Three weeks ago, we welcomed the local scientific community to join us at our headquarters in Kenmore Square for the inaugural lecture in the AI Proteins Seminar Series. Our speaker Neil King from @UWproteindesign delivered a superb seminar. Check it out👇 youtu.be/OPRMfRnlx1k
Boston Protein Design and Modeling Club retweeted
Thank you to everyone who attended the inaugural lecture in the AI Proteins Seminar Series today. Neil King @KingLabIPD gave a fantastic talk to a packed house!
Boston Protein Design and Modeling Club retweeted
We're delighted to kick off our new seminar series, and the inaugural speaker is none other than Neil King @KingLabIPD
"ML-based design of nanoparticle vaccines"
June 3rd 2026
12-1 PM EDT
Boston Protein Design and Modeling Club retweeted
The Open Molecular Software Foundation (OMSF) and the Growing Role of Open Source Software in Molecular Modeling
pubs.acs.org/doi/10.1021/acs…
@HighSpeedMode @wpwalters @ltchong @jeffreyjgray @dga_smith @bahl_lab @davidlmobley
#JCIM Vol66 Issue6 #Perspective
Boston Protein Design and Modeling Club retweeted
Really fun and challenging (!) discussion with @bahl_lab on BindCraft, the state of binder design, the oustanding challenges and perhaps also some misconceptions in the field 💫
healthtech.com/the-chain/mar…
Boston Protein Design and Modeling Club retweeted
We've got two more positions open for RAs to join @AI_Proteins! One is for our Protein Characterization group led by Alyssa Anderson, and the other is for our Biochemistry group led by @CarcamoEdson. These wet lab roles are a perfect for college students graduating this spring
Our team is growing!
We’re hiring for two new roles on our Biochemistry and Protein Characterization teams. These are hands-on, wet lab positions ideal for early-career scientists eager to make an impact and contribute to cutting-edge drug design.
aiproteins.com/careers