@RachelMThomps

bioeng.

Joined September 2022
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Inflammatory bowl disease relates to chronic inflammatory diseases in the intestines and impacts 3 million people in the United States. This article covers the genetic engineering of a form of e coli to be used for repair of these domains. See it here! nature.com/articles/s41467-0…

Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

Nature Communications - Anti-inflammatory treatments for gastrointestinal diseases can often have detrimental side effects. Here the authors engineer E. coli Nissle 1917 to create a fibrous matrix...

nature.com
With advancements in genetic engineering, this article discusses the use of CRISPR dCAS and how as a new technology platform it can be applied to synthetic biology, imaging, and more. Check it out! #OSUBioe511 sciencedirect.com/science/ar…
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PCOS affects 1 in 10 women throughout the US and as therapy this article uses mesenchymal stem cells in attempt to restore fertility via metabolic rate. Check it out. #OSUBIOE511 stemcellres.biomedcentral.co…

Mesenchymal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS...

Stem Cell Research & Therapy - Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen...

link.springer.com
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PCOS affects every one in ten women, and what this article implements transplantation of brown adipose tissue to increase circulation of adiponectin level. Check it out. #OSUBIOE511 pnas.org/doi/abs/10.1073/pna…

Brown adipose tissue transplantation ameliorates polycystic ovary syndrome | PNAS

Polycystic ovary syndrome (PCOS), which is characterized by anovulation, hyperandrogenism, and polycystic ovaries, is a complex endocrinopathy. Bec...

pnas.org
This article details the new development of a alternative human small intestine via the use of natural ECM and porcine small intestinal scaffolds. The model was created in vitro to overcome experimental setbacks used for drug delivery. #OSUBIOE511 liebertpub.com/doi/abs/10.10…

Development of an Advanced Primary Human In Vitro Model of the Small Intestine - Matthias Schwein...

Intestinal in vitro models are valuable tools in drug discovery and infection research. Despite several advantages, the standard cell line-based Transwell® mode...

journals.sagepub.com
While RGD is a commonly used peptide coating, over the years the results of cell adhesion using this peptide have been variable. This article highlights why there is variability among results as well as future applicational work. Check it out. #OSUBioe511 ncbi.nlm.nih.gov/pmc/article…

Advantages of RGD peptides for directing cell association with biomaterials

Despite many years of in vitro research confirming the effectiveness of RGD in promoting cell attachment to a wide variety of biomaterials, animal studies evaluating tissue responses to implanted...

pmc.ncbi.nlm.nih.gov
This article discusses the various forms of regulated necrosis and including arising new mechanisms for cell death - understanding how these pathways are related can allow for potential therapy with regards to degenerative diseases! Check it out! nature.com/articles/nrm3737

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Nature Reviews Molecular Cell Biology - Cell death research was revitalized by the understanding that necrosis can occur in a regulated and genetically controlled manner. Although necroptosis is...

nature.com
Graduate Fellowships for STEM Diversity aims to diversify graduate student programs, both MS and PhD, in STEM majors specifically. This fellowship is meant to aid predominately women as well as underrepresented groups. Check it out below. #OSUBioE511 stemfellowships.org/

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Strengthening the nation’s STEM workforce through merit-based fellowships and partnerships

stemfellowships.org
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