@RandauLab

Our laboratory studies Class I CRISPR-Cas biology and archaeal RNA processing pathways at the Philipps-Universität Marburg @Uni_MR. All views are our own.

Joined April 2022
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We have two postdoc positions available (funded for 3 years by Volkswagen Momentum) for research related to the de novo evolution of (i) bacterial anti-CRISPR activities and (ii) archaeal tRNA gene introns. Please feel free to share or apply: stellenangebote.uni-marburg.…
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Thank you for the detailled overview of this team effort and your hard work @patrick_pausch! If you want to see beautiful Type IV effector complexes in action, check out: nature.com/articles/s41467-0…

Structural variation of types IV-A1- and IV-A3-mediated CRISPR interference

Nature Communications - Type IV-A CRISPR-Cas systems diverge from the general CRISPR-Cas mechanism. To understand this system, the authors determine cryo-EM structures of two evolutionarily...

nature.com
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Lennart Randau retweeted
Selina Rust@SelinaRust9 Oct 2024
Happy to share our article, published today in NAR: academic.oup.com/nar/advance… Congrats to @mariana_sanlo24, @RandauLab, @ThanbichlerLab, Vicente & @royerht! Thank you so much for the nice work 🍀

Visualization of Type IV-A1 CRISPR-mediated repression of gene expression and plasmid replication

Abstract. Type IV CRISPR–Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins) effector complexes are often encode

academic.oup.com
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Lennart Randau retweeted
Biowisskomm@biowisskomm16 Oct 2024
"We're CRISPRn our way through the apocalypse". Details can be found at crispr-whisper.de/2024/08/20…. All events are free of charge. We look forward to seeing you in Marburg!
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Happy to share our paper on archaeal mRNA caps and their processing in @NatureComms: rdcu.be/drIXx Thank you very much to our very helpful partners in the labs of @JaeschkeLab, @HoerferLab, Jörg Soppa and Nicole Paczia. @Bio_UM, @SYNMIKRO
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Lennart Randau retweeted
fabienne.benz@FabBenz26 Jun 2023
Do plasmids fight other plasmids? 🧵 So happy our preprint is out!💥And yes indeed, we uncover that type IV-A3 CRISPR-Cas targets other plasmids! biorxiv.org/content/10.1101/…

Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans

Type IV-A CRISPR-Cas systems are primarily encoded on plasmids and form multi-subunit ribonucleoprotein complexes with unknown biological functions. In contrast to other CRISPR-Cas types, they lack...

biorxiv.org
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Thank you for the organization. It was fun to learn about company perspectives.
GBM e.V.@GBM_eV1 Dec 2022
Replying to @RandauLab
@RandauLab on „The diversity of non-coding RNA functions“
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Lennart Randau retweeted
Stan Brouns@StanBrouns4 Oct 2022
When microbes have to resort to the more rigorous and diverse RNA targeting CRISPR-Cas strategies to buy time, go into dormancy or commit suicide to survive phage infection. Great work by Sam van Beljouw with graphical art by Alicia Rodríguez Molina. nature.com/articles/s41579-0…

RNA-targeting CRISPR–Cas systems

Nature Reviews Microbiology - In this Review, Brouns and colleagues discuss our current understanding of RNA-targeting type III and type VI CRISPR–Cas systems by detailing their composition,...

nature.com
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Lennart Randau retweeted
GBM e.V.@GBM_eV22 Sep 2022
📢Save the date: GBM and @BioPharmaCL_GER teamed up organizing a half-day event on "The World of RNA - Translation of Basic Research to #RNATherapeutics", Dec 1 at Stadthaus #Ulm. Lectures, panel discussion, career roundtable, networking - more details at world-of-rna.org
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Thank you very much to @petergm24 lab and everybody involved! If you would like to read about how Type IV #CRISPR regulates host gene expression @NatureMicrobiol, please feel free to follow this SharedIt link: rdcu.be/cWBfW
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Lennart Randau retweeted
April Pawluk@AprilPawluk13 Apr 2022
can’t wait to review abstracts for @crispr2022 soon! we have lots of short talks available, so be sure to submit your abstract by next Friday to be considered for a talk! more info and registration at crispr2022.bio
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Great story and we were happy to help a bit with the snoRNA-seq part: Emergence of the primordial pre-60S from the 90S pre-ribosome: Cell Reports cell.com/cell-reports/fullte…

Emergence of the primordial pre-60S from the 90S pre-ribosome

Ismail et al. report the isolation of a primordial pre-60S particle, composed of a specific set of assembly factors and snoRNAs. This assembly intermediate is visualized by cryo-EM while emerging...

cell.com
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