Rheumatologist, physician scientist @umichmedicine #antiphospholipid syndrome #COVID-19 #Neutrophils #NETs

Ann Arbor, MI
Joined July 2017
Grateful for amazing mentors/collaborators @jasonsknight @YogenKanthi @JHMorrissey. Thanks to @ScienceTM 👀Prothrombotic antiphospholipid antibodies and neutrophils🕸️conspire to promote a thromboinflammatory storm in some individuals with severe #COVID19 stm.sciencemag.org/content/e…
4
9
4
43
ICYMI the NOURISH: Autoimmunity Digital Health Challenge is open to everyone including #engineeringstudents and #autoimmune patients
NIH invites innovators to join the NOURISH: Autoimmunity Digital Health Challenge! Develop digital health tools that help people living with or at risk for autoimmune diseases monitor diet, nutrition & symptoms. 💰 Up to $650K in total prizes 🏆 Up to 10 Phase 1 awards of $20K 🔗 nourishchallenge.org
1
5
453
👀
Join us today for Grand Rounds on "From Antiphospholipid Syndrome to the General Population: Decoding the Role of NETs in Thromboinflammation" by @RayZuoMD, assistant professor of Rheumatology. 📅 Aug. 21 ⏰ 12 PM 📍 Ford Auditorium or Zoom Learn more: medschool.umich.edu/events/i…
4
390
Check out our latest 🎙️w/@BharatKumarMD ! We dive into APS, AI 🤖, and the future of rheum research—plus an interesting APS case and a few (questionably good) jokes along the way 😄@jasonsknight @umichmedicine @APSFA #APS
With so much on the horizon for antiphospholipid syndrome research & the field of #rheum, what might the future look like? Dr. Yu (Ray) Zuo dives in. LISTEN → acr.tw/4qoRpGk
3
10
774
👀
APS is different for every patient, so why isn't treatment individualized? Using RNA sequencing, Ray Zuo, M.D., M.S., and team identified four clusters in APS patients beginning the process of tailoring care based on biology. Read more on Health Lab. michmed.org/rwqzd
3
175
#Medscape medical news reporting on our @TheLancetRheum manuscript for #cardiovascular risk control in #Antiphospholipid syndrome with a great discussion by @RayZuoMD medscape.com/viewarticle/too…
Excited to have led this initiative and grateful for all centres' contributions to a multiethnic study of 1001 patients with #APS, underlining the need for #cardiovascular risk management in primary APS and #SLE/APS. @TheLancetRheum thelancet.com/journals/lanrh…
5
14
1,053
RNA-seq study of aPL-positive patients identified 4 distinct clusters defined by gene expression modules & predicted immune cell compositions, offering potential to stratify APS & aPL-positive patients based on whole-blood transcriptomic profiles A&R doi.org/10.1002/art.70021
3
4
1
12
3,582
🔥NETosis, mTOR, Hippo/IL-6 signaling distinguish APS subgroups. 🧬🕸️Molecular stratification may guide risk prediction and targeted therapy beyond antibodies alone. @APSsupportUK
1
2
110
Another fruitful collaboration with @AliDuarteMD
1
2
80
❤️👀 @CircAHA Microvascular Endothelial Cells License APS Vasculopathy Through YAP1- and CCN2-Mediated Signaling ahajournals.org/doi/10.1161/…
1
10
1
19
1,437
#CatastrophicAPS affects <1% of #APS patients, causing rapid multi-organ #thrombosis. Mark’s story shows the value of coordinated care, incl. @RayZuoMD (@umichmedicine). We’ve previously shared his work; we thank him for his work helping the APS community. cutt.ly/8rG4mPQT
3
5
343
Calprotectin may serve as a mechanistically informed biomarker for atherosclerotic cardiovascular disease, independent of traditional and contemporary cardiovascular risk factors and biomarkers. ja.ma/4054WbW @dranandrohatgi
2
6
18
2,032
🩸👀 We wrote a paper for @BloodAdvances about antiphospholipid syndrome (APS), platelets, and purinergic signaling, with an eye toward potential therapeutic targets. See the Replies for a link to the article...
4
20
1
56
3,049
NEW EPISODE! @jasonsknight joins the podcast to break down the evolving science of antiphospholipid syndrome & its treatment. From antibodies to clinical trials—this is #APS like you’ve never heard it before. LISTEN NOW → acr.tw/3GxkWg8 @ACR_Journals
9
1
28
2,427
A great story showcasing the cutting-edge work coming out of the #APS Program and the APS Research Labs, led by Dr. @jasonsknight and Dr. @RayZuoMD.
Catastrophic antiphospholipid syndrome completely transformed Mark Hall’s daily life. But access to comprehensive care at U-M Health has been pivotal in treating his condition and redefining what it means to live with APS. Read Mark's story on our blog: michmed.org/JDkYV
2
1
3
730
Catastrophic antiphospholipid syndrome completely transformed Mark Hall’s daily life. But access to comprehensive care at U-M Health has been pivotal in treating his condition and redefining what it means to live with APS. Read Mark's story on our blog: michmed.org/JDkYV
1
5
1
12
1,818
June is #APSAwareness Month! Check out the latest APS Program Update, featuring our investigators in a special article with @APSFA, add'l news & achievements, a patient's story about living with APS & What I’m Reading in APS Research by Dr. Ajay Tambralli. conta.cc/4jUou9U
2
5
444
Research shows #calprotectin, a marker of #NeutrophilActivation, as a potential early indicator of #AtheroscleroticCardiovascularDisease. Elevated calprotectin levels were shown to predict future #HeartDisease risk, even in individuals without symptoms: cutt.ly/arx5jbId
5
8
624
Another 🔬fruitful🍇 collaboration w/@utswheart Grateful for the teamwork and scientific synergy🙌💡
1
1
213