Postdoctoral neuroscientist with my *attention* on the prefrontal cortex. Art, photography, & thinking about thinking.(they/them)
Toronto
Joined August 2019
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Rescuing nicotinic responses in aging by harnessing muscarinic signaling pathways. I'm so excited to have this project out, thank you @Sridevi292 @LambeLab @physiologyuoft. Check it out here rdcu.be/c3jbU
Need to recover lost #nicotinic currents? It is possible even in the older brain with #xanomeline & #NS9283. Paper now @npp_journal Kudos to stellar graduate students @saigepower @sridevi292 @physiologyuoft Here's the link: rdcu.be/c3ij5
Curious about endogenous serotonin and SSRIs in the mPFC? 🐁⚡️💊
Come by my poster today at @CAN_ACN
Saige Power retweeted
@Luna3150 @physiologyuoft used optophysiology to show that #CCK interneurons inhibit ventral hippocampus neurons tagged with #retrobead labelling from the nucleus accumbens. Great working with @jckimlab again!
I’m at #SfN2023 presenting my latest work in the @LambeLab. Come visit…
🐁 C10 (ACh in Alzheimer’s)
⚡️ C41 (Serotonin in PFC)
Our Alzheimer’s work is now on bioRxiv (tinyurl.com/43uy78rd) and you can come ask me questions Tuesday (tomorrow) morning from 8-12pm at C41!
Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models biorxiv.org/cgi/content/shor… #bioRxiv
🗣️ Happy our manuscript is taking shape!
"Serotonergic input into the mPFC regulates cognitive flexibility"
@AshleaIsHere @mark_ansorge
Another great collaboration with @LambeLab!
Check it out on BioRxiv.
👇
biorxiv.org/content/10.1101/…
Exciting NMDA receptor work from great current and former lab mates @Sridevi292 @binko_mary and collaborators @camielnik @ajr937
What happens when Grin1 deficiency leaves neurons with too few NMDA receptors (NMDARs)?
Turns out there is a selective loss of extrasynaptic NMDARs compromising dendritic plateaus.
Adult genetic intervention can bring them back!
NMDARs #beingextra
biorxiv.org/content/10.1101/…
Saige Power retweeted
So happy to be back in person at #SFN22 with nicotinians @MarinaP63 Dan McGehee Bill Green @LambeLab @Sridevi292 @SaigePower #SFN2022
Excited to be here at #SfN2022 ! Come chat with me about cholinergic deficits in aging & nicotinic rescue by xanomeline on Monday afternoon at poster D31!
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I may be "bi"ased but I'm looking forward to the work that'll come out of this on #bisexual health & well-being!
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A bird for the bird app. Red tailed hawk spotted in @GreenWoodHF during a lovely long weekend with @AMereCause in nyc
Saige Power retweeted
Xanomeline restores nicotinic receptors to cholinergic synapses in aged mice. First preprint and elegant work @saigepower @sridevi292 @physiologyuoft #acetylcholine #muscarinic #nicotinic #aging biorxiv.org/content/10.1101/…
ALT Optogenetic cholinergic currents and mechanistic schematic
