Samantha Zepeda retweeted
Can we leverage recent developments in machine-learning & protein design to tackle previously intractable challenges?
The answer is yes and we show it in this study led by the one and only @Dr_MattMcCallum
@HHMINEWS
@UWBiochemistry
1/9
biorxiv.org/content/10.1101/…
Samantha Zepeda retweeted
Are you passionate about designing vaccines against viruses and understanding how they work at the molecular level? We're hiring! Join our innovative and fun team to do science that changes the world. Please RT
@HHMINEWS
@UWBiochemistry
So grateful for the opportunity to share my work on bat borne Sarbecoviruses at the Rising Stars symposium @UofUBiochem. Excited to hear all the other amazing work being done!
Looking forward to meeting everybody at our @UofUBiochem @uofunuip third Graduate Student Rising Stars Synposium! All Utah colleagues, come and enjoy some exciting science and good times.
Samantha Zepeda retweeted
Receptor tropism & immunogenicity of bat-borne sarbecovirus. @veeslerlab @0327jimin @Sam_K_Zepeda show PRD-0038 clade 3 sarbecovirus has broad ACE2 usage. ID cross-neutralizing Abs & show PRD-0038 spike elicits more broadly reactive Abs vs #SARSCoV2 spike cell.com/cell-host-microbe/f…
Samantha Zepeda retweeted
Delighted to share the peer-reviewed version of our article investigating bat-borne sarbecovirus interactions with ACE2 host receptors and implications for pandemic prepardness!
Led by @0327jimin & @Sam_K_Zepeda
sciencedirect.com/science/ar…
How do bat-borne sarbecoviruses (i.e. SARS-CoV-1/2-like viruses) interact with host receptors and are we ready for a possible future pandemic?
Find out in this study led by @0327jimin & @Sam_K_Zepeda !
@HHMINEWS @UWBiochemistry
1/23
biorxiv.org/content/10.1101/…
Samantha Zepeda retweeted
How do bat-borne sarbecoviruses (i.e. SARS-CoV-1/2-like viruses) interact with host receptors and are we ready for a possible future pandemic?
Find out in this study led by @0327jimin & @Sam_K_Zepeda !
@HHMINEWS @UWBiochemistry
1/23
biorxiv.org/content/10.1101/…
Samantha Zepeda retweeted
There's also a nice write-up of the story from Sabrina Richards @fredhutch! fredhutch.org/en/news/center…
Samantha Zepeda retweeted
Can we correlate #SARSCoV2 spike (S) biochemical properties with the specificity, magnitude & quality of antibody responses? Put another way, how to make a good #CovidVaccine ?
@johnbowenbio led the charge to answer these questions
@HHMINEWS
1/21
biorxiv.org/content/10.1101/…
Samantha Zepeda retweeted
We characterized the structural basis of #SARSCoV2 #OmicronVariant binding to the host ACE2 receptor and neutralization by the S309/sotrovimab clinical antibody therapeutic!
Led by @Dr_MattMcCallum & Nadine Czudnochowski Collab w Gyorgy Snell
1/8
biorxiv.org/content/10.1101/…
Samantha Zepeda retweeted
Nature research paper: Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift nature.com/articles/d41586-0…
Samantha Zepeda retweeted
Our manuscript on eliciting broadly protective sarbecovirus immunity using mosaic nanoparticle RBD vaccines has been peer-reviewed and can be found here
@coronalexington led this collaboration with @KingLabIPD and many others
1/3
cell.com/cell/fulltext/S0092…
Virus-encoded histone doublets are essential and form nucleosome-like ... sciencedirect.com/science/ar…
Samantha Zepeda retweeted
A paper in @Nature reports the characterization of a human monoclonal antibody against SARS-CoV-2 that is able to neutralize diverse sarbecoviruses, including currently circulating SARS-CoV-2 variants. go.nature.com/3BjTJ95
Samantha Zepeda retweeted
Excited to share our preprint demonstrating that ACE2 binding is a deep ancestral trait of sarbecoviruses with plastic evolutionary potential. A fun collaboration with @jbloom_lab @veeslerlab @SamK_Zepeda @coronalexington @AllieGreaney biorxiv.org/content/10.1101/… 🧵👇