@SeegarLab

University of Cincinnati, College of Medicine Studying membrane tethered proteases

 Cincinnati, Ohio
seegarlab.com
Joined March 2021
  • Tweets63
  • Following59
  • Followers67
8Media
Structural basis for ADAM17 activation by the iRhom1 pseudoprotease: Cell Reports cell.com/cell-reports/fullte…

Structural basis for ADAM17 activation by the iRhom1 pseudoprotease

Ungvary et al. present the cryo-EM structure of the iRhom1 pseudoprotease bound to the ADAM17 zymogen. Structural and functional studies reveal a conserved signaling axis spanning the iRhom cytopla...

cell.com
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Congratulations to all involved! Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex | PNAS pnas.org/doi/10.1073/pnas.25…

Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex | PNAS

The endopeptidase activity of ADAM (a disintegrin and metalloproteinase)-17, the primary processor of several EGFR ligands and tumor necrosis facto...

pnas.org
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Congratulations to folks that made this work come together. biorxiv.org/content/10.1101/…

Structural Insights into the Activation and Inhibition of the ADAM17-iRhom2 Complex

The endopeptidase activity of ADAM (a disintegrin and metalloprotease) -17, the primary processor of several EGFR ligands and tumor necrosis factor-alpha (TNF-α), is essential for proper embryonic...

biorxiv.org
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Online now! Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors by Andrew N. Dates, Stephen C. Blacklow, and colleagues at @harvardmed @HMS_BCMP @DanaFarber dlvr.it/T5NScW #chembiol
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Calling incoming PhDs! We're searching for a postdoctoral fellow passionate about uncovering mechanistic mysteries related to human disease at the molecular level. #ResearchOpportunity #ScienceJobs Apply now: jobs.uc.edu/job/Cincinnati-P…
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🔬 Join our growing lab! We're searching for a postdoctoral fellow passionate about uncovering mechanistic mysteries related to human disease at the molecular level. #ResearchOpportunity #ScienceJobs Apply now: nature.com/naturecareers/job…

Post Doc Fellow, Molecular & Cellular Biosciences, Hou Lab - Cincinnati, Ohio

Post Doc Fellow, Molecular & Cellular Biosciences, Hou Lab

nature.com
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Please RT (or RX?). My lab is looking for a postdoctoral fellow with expertise in cryo-EM to solve the structure of the RAC activator VAV3 in complex with binding proteins. Please email me if interested.
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Congrats to Alex on his Notch paper published in Science Signaling! Special thanks to our fantastic team - Emily, Lena, Drew, Julia and collaborators. Click here to read the paper. science.org/doi/10.1126/scis…

A spatiotemporal Notch interaction map from plasma membrane to nucleus

Proteolytic liberation of the Notch intracellular domain occurs at an intracellular compartment.

science.org
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Congrats to Colin with a special thanks to Emily and Khal!
Cell@CellCellPress28 Jul 2023
Now online! Structural basis for membrane-proximal proteolysis of substrates by ADAM10 dlvr.it/SstpJ6

Structural basis for membrane-proximal proteolysis of substrates by ADAM10

Membrane-proximal proteolysis by ADAM10 depends on both relief of autoinhibition and distance measurement by its partner tetraspanin.

cell.com
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Randy J. Read et al.: AlphaFold and the future of structural biology @Cambridge_Uni @AucklandUni @uwanews @UniofOxford @ActaCrystD @IUCr #AlphaFold #ProteinStructurePrediction #Crystallography doi.org/10.1107/S20597983230…
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Congratulations to @HMS_BCMP faculty member Karen Adelmen for her election to the American Academy of Arts and Sciences!  @AdelmanLab @harvardmed
American Academy of Arts & Sciences@americanacad19 Apr 2023
Congratulations to our new members! Just announced! We are honoring the excellence of extraordinary leaders in an array of disciplines and professions. The first members were elected in 1781. Learn who was elected in 2023: amacad.org/news/2023-member-…
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Our paper is out @ScienceAdvances! Check out how a single line of inner hair cells within the mammalian cochlea🐚 forms. Congrats to the fantastic @roecon91 @ShaharTaiber & Olga Loza. See the thread below. science.org/doi/10.1126/scia…
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We have a Research Assistant position open in the Thompson Lab! We are looking for hard working individuals who are not afraid to learn new and diverse research techniques. Please see application links below. Fellow scientists please RT to spread the word!
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Thanks to the folks @uofcincy for hosting a fun visit. Great to talk RNA regulation with @SeegarLab @catmak23 @igal_ifergan @TheLuolab @vestkat @IkegamiLab and others in the @biologyUC and @CincyChildrens - infectious enthusiasm in the grad students and faculty!
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AlphaFold predictions: great hypotheses but no match for experiment biorxiv.org/content/10.1101/…

AlphaFold predictions: great hypotheses but no match for experiment

AI-based methods such as AlphaFold have raised the possibility of using predicted models in place of experimentally-determined structures. Here we assess the accuracy of AlphaFold predictions by...

biorxiv.org
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Structural Basis for Selective Proteolysis of ADAM10 Substrates at Membrane-Proximal Sites biorxiv.org/cgi/content/shor…
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Our department is hiring! We have a collegial and supportive environment for junior faculty here. Please feel free to DM me if you have any questions! Assistant/Associate Professor, Structural Biology & Cryo-EM, Department of Molecular Genetics jobs.uc.edu/s/TCtrz8
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BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Congratulations to the @KovallRhett Lab and first author, Dr. Ellie Gagliani for their recent publication on understanding the mechanisms that drive Notch target gene dysregulation. pubmed.ncbi.nlm.nih.gov/3595…

A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism...

Notch signaling is a conserved pathway that converts extracellular receptor-ligand interactions into changes in gene expression via a single transcription factor (CBF1/RBPJ in mammals; Su(H) in...

pubmed.ncbi.nlm.nih.gov
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We are hiring! PostDoc and RA positions are open to folks interested in studying membrane enzymes. Learn more and apply here: jobs.uc.edu/job/Cincinnati-P… jobs.uc.edu/job/Cincinnati-R…
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