Effect of Sacubitril/Valsartan on Cognitive Function in Patients With Heart Failure With Preserved Ejection Fraction: A Prespecified Analysis of PARAGON-HF 👥2895 patients included in the MMSE substudy with baseline MMSE score measured mean age 73 years ⏰ follow-up was 32 months. 👉Cognitive change, measured by MMSE, did not differ between treatment with sacubitril/valsartan 🆚 valsartan in HFpEF 📁🆓@CircAHA ahajournals.org/doi/abs/10.1…

Excelent review👉Contemporary pharmacological treatment and management of #HF 👉stage A pre-HF might benefit from close monitoring and early treatment and prevention strategies 👉The first-line treatment of patients with HFrEF includes initiation and optimization of foundational therapy 👉Additional pharmacological therapies for patients with HFrEF include hydralazine and nitrates in Black patients and consideration of ivabradine, vericiguat and digoxin in selected symptomatic patients 👉Treatment HFmrEF or HFpEF now includes SGLT2i as first-line therapy; additional therapies include diuretics & consideration of ARNIs, ARBs and MRAs in patients with HFmrEF or HFpEF, and ACEIs or ARBs and β-blockers in patients with HFmrEF 📁 nature.com/articles/s41569-0… @NatureMedicine

✅The Cardioprotective and Anticancer Effects of SGLT2i 👉 Observational studies suggest SGLT2I protect from cardiotoxic chemotherapy. 👉Preclinical studies show cardioprotective and anticancer effects of SGLT2i. 👉Randomized clinical trials are warranted to test SGLT2I in cardio-oncology @JACCJournals 📁 jacc.org/doi/10.1016/j.jacca…

⚠️2024 @ACCinTouch Expert Consensus Decision Pathway for Treatment of #HFrEF 👉 How to Initiate, Add, or Switch to Evidence-Based Guideline-Directed Therapy for HFrEF 👉 How to Achieve Optimal Therapy Given Multiple 💊 for HF, Including Augmented Clinical Assessment That May Trigger Additional Changes in GDMT 👉 When to Refer to an HF Specialist 👉 How to Manage Common Comorbidities 👉 How to Integrate Palliative Care @secardiologia #CardioTwitter 📁🆓 jacc.org/doi/10.1016/j.jacc.…