@SemrauLab

The Semrau Lab is interested in quantitative stem cell biology. We use molecular profiling and machine learning to study iPSC-derived disease models.

 New York Stem Cell Foundation
semraulab.com
Joined September 2015
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  • Following150
  • Followers331
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Congratulations to DR. Maria Mircea for defending her PhD thesis today! It was a true honor to serve on her committee and I'm so inspired by the amazing work! Congrats also to @SemrauLab, the proud mentor!
Maria Mircea@Siliegia20 Dec 2022
Received my PhD today! Many thanks to my supervisor @SemrauLab. Thanks to @ItaiYanai for being part of my committee. And also thanks to my paranymphs @JuliaEckert10 and @GeorgeDadu_!
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After 4 days of exciting talks, posters, discussions and lots of fun, #CLD2022 finally came to an end today! A very big thanks to all the participants for joining us at #Alleppey for this Symposium and making it a huge success! Here's a group photo of all the CLD attendees! ✨
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New Night Science paper! "What puzzle are you in?" Doing science is like solving puzzles; of which we propose there are 4 Classes. But in a research project, you can't be sure what kind of a puzzle you're in; requiring "puzzle-switching". genomebiology.biomedcentral.… @MartinJLercher
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Thrilled to announce the 2022 Night Science 1 day workshop! Join us in Amsterdam August 9th to learn & practice the creative scientific process. Thank you to @BasTeusink and @AIMMS1 for hosting and enabling free registration (with lunch): tinyurl.com/y3u3x4sp @MartinJLercher
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Ever hear that ‘necessity is the mother of invention’? In our new work, we found that it’s also true for cancer cells as they continuously adapt to drug treatments. We call it a ‘resistance continuum’ that's dependent on treatment history. biorxiv.org/content/10.1101/… @Gustavo_SFranca
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Our new paper from @SemrauLab on clusterability of scRNA-seq data is now published in Genome Biology! The new name is phiclust and the code is available at Github github.com/semraulab/phiclus….
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Basic science is the most powerful process in the universe for generating knowledge, but it is often misunderstood. It says 'let scientists follow their curiosity and sometimes they will discover great things'. The discovery can come from anywhere, from anyone, studying anything.
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Extremely excited to share our recently published paper in @Nature where we report formation of a faithful in vitro model of human blastocyst. @NRivron lab @IMBA_Vienna A long tweetorial alert! [1/29] nature.com/articles/s41586-0…

Human blastoids model blastocyst development and implantation

Nature - Blastoids derived from naive PXGL-cultured human pluripotent stem cells in which Hippo, TGF-β and ERK pathways are inhibited closely recapitulate aspects of blastocyst development,...

nature.com
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Are you interested in the decision-making of single cells? Check out our new review paper from @SemrauLab. We review the important molecular players and single-cell methods to measure them! portlandpress.com/biochemsoc…
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Come join our awesome team to develop methods to analyze spatial transcriptomic data and help us understand brain abnormalities in Duchenne muscular dystrophy lumc.nl/over-het-lumc/werken…
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New Resource online now CellStemCell: Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification zpr.io/R8XkJ

Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals...

Meistermann et al. use scRNA-seq, pseudotime analysis, and immunofluorescence validation to reconstruct the sequence of molecular events occurring in time-lapse-staged human preimplantation embryos....

cell.com
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Our paper describing a progressive learning approach (scHPL) to build cell hierarchies and classify single cell data is out: nature.com/articles/s41467-0…. Awesome work by @liekemichielsen

Hierarchical progressive learning of cell identities in single-cell data

Nature Communications - Classification methods for scRNA-seq data are limited in their ability to learn from multiple datasets simultaneously. Here the authors present scHPL, a hierarchical...

nature.com
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3 recent preprints have shown the formation of neural tube like structures in gastruloids. biorxiv.org/content/10.1101/… biorxiv.org/content/10.1101/… biorxiv.org/content/10.1101/… In all cases, despite protocol differences, gastruloids show a very potent morphogenic capacity.
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XEN+ES cells aggregates Interesting variation on the original #gastruloid model. @biorxivpreprint from @SemrauLab biorxiv.org/content/10.1101/… XEN cells induce epithelializaton and anterior neural fate in #gastruloids
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Some @biorxivpreprint are cited frequently
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SemrauLab retweeted
Itai Yanai
@ItaiYanai3 Dec 2017
Big data is nothing without big thinking
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Also, if you think only jerks can be super successful scientists, let Shalev Itzkovitz serve as the ultimate counterexample—a lovely person! xitter.cf/arjunrajlab/status/895…
Arjun Raj
@arjunrajlab10 Aug 2017
Wow, amazing study from @AndreasMoor / Itzkovitz lab: mRNA localization influencing translational efficiency in gut: science.sciencemag.org/conte…
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SemrauLab retweeted
NanoFront@NanoFront9 Aug 2017
#vacancies in the groups of @SemrauLab, @DanielaJKraft, @sensemolen @youklab, @ymblanter @TNWTUDelft @LeidenPhysics @QuTech_news apply now! xitter.cf/CasimirResearch/status…
Casimir_Research@CasimirResearch9 Aug 2017
Replying to @NanoFront
@NanoFront awarded 11 new research projects. Dreaming of a paid PhD position @UniLeiden or @tudelft? Apply now: casimir.researchschool.nl/va…
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Everyone is welcome at Leiden University! Iedereen is welkom bij de Universiteit Leiden! #HappyPride #BastionofFre… ift.tt/2vAbGki
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I love the simplicity and power of this model biorxiv.org/content/early/20… Happy to finally implement it on a free server web.northeastern.edu/slavov/…
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