Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation academic.oup.com/nar/article…
Shamik Sen retweeted
In a recent study published in the Journal of the American Chemical Society, researchers from IIT Bombay and collaborators from IIT Kanpur and CNCI, Kolkata uncover how collagen accelerates clumping of hormones in the pancreas, identifying a previously unknown diabetes trigger and a potential new drug target. They have identified an important missing link: fibrillar collagen I, a major component of the extracellular matrix. Prof. Shamik Sen from the Department of Biosciences and Bioengineering at IIT Bombay led and oversaw the project.
iitb.ac.in/research-highligh…
Shamik Sen retweeted
A study by a team led by Prof. Anirban Banerjee reveals how a host protein named VCP/p97 works like an elite special operation unit which detects external bacteria & neutralises them before they can make us sick.
timesofindia.indiatimes.com/…
Shamik Sen retweeted
Neha Saxena @Neha20656671, Shamik Sen @ShamikSen9 and colleagues find that ECM stiffness influences MSC differentiation to CAFs and impacts on breast cancer invasion.
Highlight: journals.biologists.com/jcs/…
Article: journals.biologists.com/jcs/…
ALT Spatial positioning of CAFs (red) and MDA-MB-231 cells (green) at the invasive front. Intensity profiles along lines drawn in the boxed regions show the relative positions of CAFs and MDA-MB-231 cells from front (F) to rear (R).
Our work on stiffness-dependent MSC differentiation into CAFs is highlighted by J. Cell Science. A wonderful collaboration with @Quasarzafar and @dr_omshree.
Differentiation of MSCs into CAFs - a story of stiffness journals.biologists.com/jcs/…
Differentiation of MSCs into CAFs - a story of stiffness journals.biologists.com/jcs/…
Shamik Sen retweeted
Wonderful study!
Interested in what mechanical quantities and structures cells probe in developing embryos during cell differentiation events? Check out our recent paper and 🧵 below. And yes, we are thrilled that our work made the January cover of @NatureMaterials! 🤩
nature.com/articles/s41563-0…
Shamik Sen retweeted
WRCB announces a summit on ‘Next Generation Therapeutics’ (Drug discovery & delivery; Regenerative medicine) at @iitbombay on 18th Nov. Register now: bit.ly/3MAhH6a
Details: bit.ly/3MFLFp @WadhwaniF @debjanipaul @abhijit_MLab @ShamikSen9 @DokRub @SINEIITB
Shamik Sen retweeted
Are you interested in doing research? Do apply to our Ph.D. program @BsbeIitb @iitbombay
The last date to apply is October 25, 2022. Interviews in December 2022. Ph.D. program starts in January 2023
Excellent work by my colleague Ranjith.
Our new paper. Post-doctoral work of @nitkal. A wonderful collaboration with my Electrical Engg colleague Prof. Sibi Raj Pillai. Thank you @serbonline @DBTIndia for funding. Generous postdoc support from @iitbombay and @BsbeIitb
Shamik Sen retweeted
Under laminar fluid shear, cells deform elliptically, align in flow direction, and rotate. From this, we can infer the frequency-dependent viscoelastic cell properties - quantitatively, accurately, and with high throughput of ~100 cells/sec. bioRxiv biorxiv.org/cgi/content/shor…
Shamik Sen retweeted
Dear @narendramodi Thank you for inviting suggestions. I have two suggestions: (1) IITs should grow beyond undergraduate teaching places and focus much more on research and innovation. Some efforts are being taken in this direction, but we need to do much more. (1/3).
Shamik Sen retweeted
Check out our 'First person' interview with Amlan Barai @AmlanBarai on his Postdoc work @ShamikSen9 @iitbombay, using multidisciplinary approaches to understand cell behavior and cellular dynamic processes including cancer development: ow.ly/EHuz50HfHaJ
Our work demonstrating the importance of MMP-mediated matrix remodelling in ESC differentiation published in @Biomaterials. Congrats to first author Kavitha. Thanks to @KiranKondabagil and Dr. P. Chandra Shekar for their important contributions. sciencedirect.com/science/ar…
Our work on regulation of cancer invasiveness by α-actinin-4 mediated regulation of myosin IIB expression and myosin IIA localization at the lamellipodium-lamella interface out in the Journal of Cell Science. journals.biologists.com/jcs/…
Shamik Sen retweeted
Our paper on role of ECM stiffness-tuned exosomes in cancer invasion out in Biomaterials sciencedirect.com/science/ar…
Our paper on role of ECM stiffness-tuned exosomes in cancer invasion out in Biomaterials sciencedirect.com/science/ar…
Our work on importance of phenotypic heterogeneity in enhancing cancer invasiveness. We also establish a biophysical basis for enrichment of cancer stem cells at the invasive front. jcs.biologists.org/content/e…
Shamik Sen retweeted
Insightful read. "The life of a professor is a constant balancing act where we try to juggle personal and professional responsibilities under the pervasive stress of managing expectations in an often hypercompetitive culture.".elifesciences.org/articles/5… @eLife @IISERPune
Collaborative effort with @Quasarzafar on pre-metastatic niche as a driver of breast cancer invasion and metastasis biorxiv.org/content/10.1101/…
