The Laboratory for #Muscle Biology: Deciphering the Molecular Mechanisms that Control #CellSize | Putting the Brakes on #MuscleWasting in #Aging or #Disease.
Technion, Israel
Joined August 2021
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What happens when muscles stop feeling gravity? check out our new review paper in EMBO Rep: link.springer.com/article/10…. Congratulations to Sandhya and Samrat (@iamsamrat96). #MuscleBiology #Microgravity #SpaceBiology #Mechanobiology #MuscleAtrophy
A wonderful two days at Harvard Medical School celebrating the legacy of Fred Goldberg. Grateful to all the speakers, attendees, sponsors, and organizers who helped make this symposium such a meaningful event: my-site-p8oyrfad-shenhavocoh…
#Harvard #ProteinDegradation #MuscleBiology
Beautiful paper by Andreas Martin group: nature.com/articles/s41467-0…
Shenhav Shemer Lab retweeted
The back works in layers.
Big muscles move the body.
Deep muscles stabilize the spine.
Exploded views make this logic visible.
Animation based on the SciePro 3D anatomy model. More info: sciepro.com/licensing
#anatomy #backmuscles #meded #sciepro
Shenhav Shemer Lab retweeted
Insulin as an Accelerator and Brake of Aging: From Molecular Landscape to Clinical Interventions
onlinelibrary.wiley.com/doi/…
This is a cool mechanism that can potentially explain why constantly contracting muscles (such as the heart) are relatively protected from wasting.
Now online! Membrane potential mediates the cellular response to mechanical pressure dlvr.it/TPdCMt
Shenhav Shemer Lab retweeted
Small-Molecule Targeting MuRF1 Protects Against Denervation-Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms
onlinelibrary.wiley.com/doi/…
Effects of Long-duration human spaceflights on the heart: pubmed.ncbi.nlm.nih.gov/4122…
Wow, now ubiquitin is also in extracellular fluids and promotes tumor microenvironment, fascinating. pubmed.ncbi.nlm.nih.gov/4122…
Check out our new review paper in FEBS J on emerging therapeutic targets that are muscle fiber-type-specific, by @iamsamrat96 and Raz Ben-David:
febs.onlinelibrary.wiley.com…
Just attended a wonderful meeting in beautiful Nara, Japan! inspiring discussions, new collaborations, and outstanding talks at the forefront of proteasome research! Grateful for the opportunity to present our work and be part of such an exceptional community!
Shenhav Shemer Lab retweeted
🚨 Thrilled to share our new review is out in @FEBSJournal. We discuss fiber-type–specific strategies to combat muscle atrophy. Grateful to Prof @Shenhav_Lab for mentorship and support. Excited to see how these insights shape future therapies.
#muscle
tinyurl.com/3pff8d94
Shenhav Shemer Lab retweeted
New! Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging dlvr.it/TKT483
Shenhav Shemer Lab retweeted
Activin A is deeply involved in the progression of sarcopenia and leads to poor prognosis in lung cancer patients
nature.com/articles/s41598-0…
Shenhav Shemer Lab retweeted
Sunita Williams and Butch Wilmore experienced zero gravity in space, accelerating their bone loss. After 9 months in microgravity, their bodies have lost balance. On returning to Earth, they won’t be able to stand immediately due to muscle atrophy. [ICSP]
#sunitawilliamsreturn
Shenhav Shemer Lab retweeted
Congrats to @StainierLab and colleagues for this interesting new @Nature manuscript: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy. #DMD tinyurl.com/4ky93z67
I was honored to speak at Ilan Ramon International Space Conference, @ILSpaceAgency. Inspiring lectures, brilliant scientists, and great connections. Grateful to be part of such a groundbreaking community! ws.eventact.com/ilanramon202…
#SpaceScience #IlanRamonConference #Inspiration
circular RNAs and atrophy:
pubmed.ncbi.nlm.nih.gov/3941…
I am deeply honored to be part of the DREAMS project and to collaborate with such a remarkable team of scientists on this groundbreaking research initiative!
Proud to highlight the @TechnionLive - Israel Institute of Technology as a key partner in the @DreamsPjt_EU! 🇮🇱 Their research will be crucial for understanding #RareDiseases and paving the way for new therapies.
👉Learn more about our partnership: dreamshorizon.eu/meet-the-te…
Shenhav Shemer Lab retweeted
Proteasome gene expression is dependent on both PAX4 and α-PALNRF-1. Findings from Gilda et al. @Shenhav_Lab show that PAX4 and α-PALNRF-1 represent new therapeutic targets to inhibit proteolysis in catabolic diseases (e.g., type-2 #diabetes, #cancer). hubs.la/Q02xLDdd0
