@SikhScientist

Post-Doctoral Research Fellow at @RDMOxford investigating #HeartFaliure and #Arrhythmia

Joined October 2015
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Excited to share our latest work published today in Cardiovascular Research linking dysregulated mitochondrial energetics as mechanisms of arrhythmia in PITX2 deficiency 🫀 academic.oup.com/cardiovascr… Key findings in 🧵⬇️ #Cardiometabolism #CardioTwitter #Arrhythmia #EPeeps

PITX2 deficiency leads to atrial mitochondrial dysfunction

AbstractAims. Reduced left atrial PITX2 is associated with atrial cardiomyopathy and atrial fibrillation (AF). PITX2 is restricted to left atrial cardiomyo

academic.oup.com
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@CVS_UoB
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birmingham.ac.uk/news/2024/g…

Gene-related metabolic dysfunction may be driving heart arrhythmia - University of Birmingham

Deficiency in PITX2 gene leads to less efficient mitochondria in heart cells of patients with Atrial Fibrillation

birmingham.ac.uk
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Jasmeet Singh retweeted
Abdullah Khan@AbAttacks27 Mar 2024
Morning everyone! Pleased to share a detailed protocol of our bone marrow organoid approach in @NatureProtocols : nature.com/articles/s41596-0….

Generating human bone marrow organoids for disease modeling and drug discovery

Nature Protocols - This protocol can be used to generate three-dimensional vascularized bone marrow organoids from human induced pluripotent stem cells. The organoids contain key stromal and...

nature.com
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Oxford_IDRM@IdrmOxford13 Sep 2023
💡Research Spotlight! Study co-authors Jasmeet Reyat @SikhScientist from IDRM and Abdullah Khan @AbAttacks from @MRC_WIMM share insight into a new method to make cardiac microtissue models. Read about the research published in @FrontCVMedicine here: tinyurl.com/mrx4h7c7
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Are you fascinated by cardiac #organoids? 🤩 If yes, then you might want to check out this @FrontCVMedicine article by Drs. Jasmeet Singh (@SikhScientist), Abdullah Khan (@AbAttacks), and colleagues at @ICVS_UoB!
Frontiers in Cardiovascular Medicine@FrontCVMedicine7 Sep 2023
Do you use cardiac microtissues in your research? Read this new original research article which demonstrates generation of chamber specific cardiac microtissues. #Organoids @SikhScientist @AbAttacks

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Do you use cardiac microtissues in your research? Read this new original research article which demonstrates generation of chamber specific cardiac microtissues. #Organoids @SikhScientist @AbAttacks

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Alongside @AbAttacks, we are delighted to share our recent publication on #Organoids published in @FrontCVMedicine where we develop chamber-specific cardiac microtissues to model cardiac fibrosis frontiersin.org/articles/10.… #Cardiology #CardioTwitter #cardiovasculardisease
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Our model complements a wide array of cardiac microtissues currently published (see excellent reviews by @MummeryLab and @Joseph_C_Wu ) in an ever-growing field ahajournals.org/doi/full/10.… ahajournals.org/doi/10.1161/…

Cardiac Tissues From Stem Cells | Circulation Research

The ability of human pluripotent stem cells to form all cells of the body has provided many opportunities to study disease and produce cells that can be used for therapy in regenerative medicine....

ahajournals.org
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A special thanks to all the co-authors and funding @Wellcome @BHF @MRC_WIMM @ICVS_UoB @IdrmOxford @OxfordDPAG
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