Structural biologist loving life in the world of Bdellovibrio research.
Joined January 2023
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Pleased to announce our pre-print on BioXriv. TULIP proteins are lipid binding proteins in the form of a hydrophobic tube. We show that in Bdellovibrio a TULIP adapter protein opens up this tube by inducing a a huge conformational change. biorxiv.org/content/10.1101/…
Simon Caulton retweeted
The missing piece in the bacterial #ESCRT-III story.. #Vipp1 forms dynamic spiral filaments on membrane! Spirals are springs that drive 3D ring formation in the spiral centre! 😎😵💫 Wonderful collaboration with @Colom_D @RouxLab… 1/2
biorxiv.org/content/10.1101/…
Simon Caulton retweeted
Very happy to share our new work about the newly identified SopA protein and
its role in the control of type IV pili formation.
Paper is now online DOI: 10.1128/jb.00108-24
Simon Caulton retweeted
Captain Aureispira - a bacterial pirate ship🦜🏴☠️🪝- boarded @ScienceMagazine. Check out the manuscript here: science.org/doi/10.1126/scie… and have a look on our extended thread below ⬇️We provide new insights on bacterial predation from molecules ⚛️to ocean samples 🌊
Bacteria can be pirates too... 🏴☠️ Let us introduce you to Captain Aureispira ⛵️ A bacterial pirate ship loaded with canons 💉 and grappling hooks 🪝🌴predating on other bacteria 🦠 Check the preprint: biorxiv.org/content/10.1101/… #predation #T6SS #T9SS #cryoEM #cryoET #teamtomo 🧵1/6
Simon Caulton retweeted
Happy and super excited to share our discovery of a protein fractal! We unravel the surprisingly simple emergence of these marvellous structures and show it might have even been an accident of evolution. Read the full story here
nature.com/articles/s41586-0…
Or just stick around 🧵
Amazing work from @Bdello_Lab_Nott nature.com/articles/s41467-0…
Simon Caulton retweeted
Team headed by Andrew Ward determined the cryo-EM structures of the mechanosensitive ion channels OSCA2.3 and OSCA1.2 providing insights into the mechanism of mechanotransduction in OSCA channels @WardLab1 @scrippsresearch
cell.com/structure/fulltext/…
Simon Caulton retweeted
Jumbo phage proteins co-opt host ribosomes immediately upon infection. We provide a resource for complexes in PhiKZ-infected Pseudomonas cells. #PhageDiversity #PhageComplexes @JoergLab @RobLavigne1 @BoettcherCryoEM @Uni_WUE @Helmholtz_HIRI nature.com/articles/s41564-0…
Simon Caulton retweeted
My first paper from @JohnInnesCentre with @Tung_BK_Le is now out! 😃If you like bacteria and mobile genetic elements, consider reading our review on wonderfully weird #genetransferagents below👇sciencedirect.com/science/ar…
Simon Caulton retweeted
Teaching Nature to Break Man-made Chemical Bonds. For the first time, scientists have engineered an enzyme that can break stubborn man-made bonds between silicon and carbon.
caltech.edu/about/news/teach…
Simon Caulton retweeted
Bacteria can be pirates too... 🏴☠️ Let us introduce you to Captain Aureispira ⛵️ A bacterial pirate ship loaded with canons 💉 and grappling hooks 🪝🌴predating on other bacteria 🦠 Check the preprint: biorxiv.org/content/10.1101/… #predation #T6SS #T9SS #cryoEM #cryoET #teamtomo 🧵1/6
Simon Caulton retweeted
Cryo-EM structure of the prokaryotic SPARSA system complex (PDB code: 8JL0) #scivis #sciart #proteinimaging #molecularart
behance.net/gallery/18982404…
Simon Caulton retweeted
Latest from our Lab. Cryo-EM studies revealed a unique mode of mycobacterial ribosome hibernation. Reported in @NatureComms
rdcu.be/dwu0B
Thnaks @unescorcb @serbonline @DBTindia @rajesh_gokhale @CCAMP_Bangalore @Ribosome_papers @cryoEM_papers @kumarN2348 @shivani0730
Simon Caulton retweeted
Exciting day. Just found out we not only got the cover we tried for but also got a nice highlight of the beautiful paper by @SundharramanS cell.com/structure/fulltext/…
Simon Caulton retweeted
Like protein secretion? Like mycobacteria? Exciting postdoc opportunity 👇
Contact me or @Lis_Lowe if you’re interested!
jobs.ncl.ac.uk/job/Newcastle…
Simon Caulton retweeted
Now published:
The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression
A great collaboration with W. Steinchen, @diepold_lab, Timo Glatter, @BangeBalcony, @KaHochberg
rdcu.be/dvfXz @SYNMIKRO @mpi_marburg
1/3
Simon Caulton retweeted
Great work by the groups of Liz Sockett (@UniofNottingham) and Andy Lovering (@UoBbiosciences @IMIBirmingham)
🦠Scientists from @unibirmingham & @UniofNottingham have solved the mystery of how predatory bacteria recognize prey.
This may enable the use of these predators to target bacteria that cause food spoilage and issues in healthcare & the environment.
👉birmingham.ac.uk/news/2023/s…
ALT Bd2740 - a MAT fibre within the Bdellovibrio bacteriovorus genome. The bulb on the right side of the fibre is the part that attaches to Bdellvibrio's prey.
Simon Caulton retweeted
Scientists solve the mystery of how predatory bacteria recognises prey - new research from Prof Liz Sockett @Bdello_Lab_Nott @UonLifeSci and Prof Andrew Lovering @UoBbiosciences published @NatureMicrobiol
Read more - ow.ly/F6Hy50QnNIZ
Simon Caulton retweeted
Nature research paper: A new antibiotic traps lipopolysaccharide in its intermembrane transporter go.nature.com/3H7hrKc
Simon Caulton retweeted
😮 anti-Phage defense papers
Nature research paper: Ubiquitin-like Conjugation by Bacterial cGAS Enhances Anti-phage Defence go.nature.com/3EH4nKs
