@SimonJohnLab

Our lab investigates molecular features of #glaucoma @Columbia . Tweets from members of the lab.

 New York, NY
simonjohnlab.org
Joined September 2020
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  • Following62
  • Followers93
New Nature Communications paper: Elevated IOP causes vein-specific BRB breakdown in glaucoma, associated with MFSD2A loss and increased endothelial transcytosis. Stabilizing endothelial β-catenin reduced leakage and mitigated neurodegeneration. nature.com/articles/s41467-0…

Intraocular pressure induced blood retinal barrier compromise in mouse models and human glaucoma

Nature Communications - Glaucoma is a common cause of vision loss. Here the authors show that elevated intraocular pressure disrupts the blood retinal barrier (BRB) and contributes to retinal...

nature.com
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🧐New study: pyruvate and related metabolites may boost resilience to glaucoma in individuals with high genetic risk. Read the article here: elifesciences.org/reviewed-p…
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This article was just published in Nature Communications. Congrats, @cubical and @SimonJohnLab! Hard work pays off! nature.com/articles/s41467-0…

FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-CADHERIN

Nature Communications - In the eye, intraocular pressure (IOP) regulation is critical for proper vision. High IOP can result in glaucoma a blinding disease. Here the authors show that tyrosine...

nature.com
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👁️Our latest preprint is out! We reveal an exciting, previously overlooked mechanism contributing to glaucoma pathogenesis: IOP-induced blood-retinal barrier breakdown. Check it out here: biorxiv.org/content/10.1101/…

IOP-induced blood-retinal barrier compromise contributes to RGC death in glaucoma

The integrity of the blood-retinal barrier (BRB) has been largely unexplored in glaucoma. We reveal that elevated intraocular pressure (IOP) partially compromises the BRB in two human-relevant...

biorxiv.org
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🚨📜Check out our latest preprint: "TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma" biorxiv.org/content/10.1101/…

TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma

Glaucoma is a leading cause of irreversible blindness worldwide. Toll-like receptor 4 (TLR4) is a pattern-recognition transmembrane receptor that induces neuroinflammatory processes in response to...

biorxiv.org
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Simon John Lab retweeted
cubical/kizhatil@cubical4 Sep 2023
Paper Alert- new preprint dropped- awesome collab with @LadyGlaucoma and @SimonJohnLab - multimodal sequence profiling of the mouse #Schlemmscanal and more-tweetorial to follow!! biorxiv.org/content/10.1101/…

Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three...

Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs)...

biorxiv.org
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The Department of Ophthalmology is seeking a Staff Associate to work in a dynamic experimental genetics laboratory at Columbia University with duties at the Manhattanville campus. The laboratory focuses on the genetics, pathophysi…lnkd.in/eYxyTKyx lnkd.in/eDxYBV6Z

Academic Search and Recruiting | Christa Montgomery

The Department of Ophthalmology is seeking a Staff Associate to work in a dynamic experimental genetics laboratory at Columbia University with duties at the Manhattanville campus. The laboratory...

linkedin.com
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I’m #hiring. Know anyone who might be interested? lnkd.in/eU7zDsWE
The John Lab is #hiring ! Check out our Research Associate I posting and come work with us at Columbia University: opportunities.columbia.edu/e… Please RT
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The John Lab is #hiring ! Check out our *updated* Research Associate posting and come work for us at Columbia University: opportunities.columbia.edu/e… Please RT.
The John Lab is #hiring ! Check out our *updated* Colony Manager posting and come work for us at Columbia University: opportunities.columbia.edu/e… Please RT.
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The John lab is hiring! 2 Research Associate positions available. Come work with us in Columbia University. For more info, to apply: opportunities.columbia.edu/e… . opportunities.columbia.edu/e… Please RT.
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What we do: Cool glaucoma research. What we need: Dedicated and motivated applicants. What we offer: A competitive salary, training, mentorship, and a boost to your career.
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The John lab is hiring a mouse colony manager! Come work for us at Columbia in vibrant NYC. The position will provide exposure and training in areas including mammalian genetics, neuroscience, molecular biology, and physiology! For more info, to apply: opportunities.columbia.edu/e…
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Another recent publication: dmm.biologists.org/content/e… Study led by Nick Tolman identifies differential vulnerability to glaucoma in Lmx1b mutant mice.
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Highlighting recent publications from our lab: pubmed.ncbi.nlm.nih.gov/3331… An excellent study led by @pete_the_teapot and Jeff Harder on disturbed metabolism in glaucoma and protection by rapamycin.

Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin...

Intraocular pressure-sensitive retinal ganglion cell degeneration is a hallmark of glaucoma, the leading cause of irreversible blindness. Here, we used RNA-sequencing and metabolomics to examine...

pubmed.ncbi.nlm.nih.gov
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