Follow us for the latest research updates of cutaneous squamous cell carcinoma #metastasis #cSCC #cell #Therapeutic #squamous #skin #cancer #media #cutaneous
Mars
Joined August 2020
- Tweets447
- Following52
- Followers232
- Likes515
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
This @JAMADerm editorial discusses a novel risk stratification system for cutaneous squamous cell carcinoma that was developed using a retrieval augmented generation–enabled large language model.
ja.ma/445Wzzb
Role of CTCF in #cscc progression
🚨 New preprint!
CTCF Binding Site Mutations: Linking TAD Dysregulation to cSCC Progression
We show how mutations at CTCF sites drive metastasis in skin cancer.
🧬📊
#Genomics #CTCF #3Dgenome #cSCC #Bioinformatics #Cancer #nswheath
researchsquare.com/article/r…
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
Most viewed this week from @JAMAOnc:
ICIs can treat advanced cancers in solid organ transplant recipients, especially cSCC, but overall survival is limited, and mTOR inhibitors with steroids may reduce rejection risk.
ja.ma/4eJFcYN
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
An in-depth look at the involvement of kindlin-1 in cutaneous squamous cell carcinoma (SCC). 👀
Drs. Carrasco, Brunton, and colleagues at @EdinCRC provide evidence that Kindlin-1 loss 🚫 in SCC can promote invasion through the upregulation of MMP13.
🔗 go.nature.com/3zz41G5
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
New Post! Thank you to Dr. Michael Baddour, Head & Neck Surgeon at Emory University, who composed this expert review of the importance of understanding perineural spread in cutaneous squamous cell carcinomas of the head and neck. #AHNSSkin @AHNSinfo
ow.ly/1c9150SzPYB
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
What differentiate $MDNAF from other #IL2 is "Durability"
Many are asking me, why $HOWL is down so much despite the CR they had in Cutaneous SCC?
So I went back to $HOWL slides & looking deeper into the slide while focusing ONLY on the high dose (disregard all the lower dose from dose escalation) we can see the 2 PR's patients went back to "Progressive Disease" 8 weeks from getting PR!
Many patients on the high dose >12mg/kg progressed after 8 - 16 weeks!
On the other hand, $MDNA.to show that all patients who had a clinical activity had a longer period of time on the drug, including a 2 years PDAC patient 100% free!
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
⚠️#Hydrochlorothiazide: #cutaneous_squamous_cell_carcinoma (SCC)
☀️In a case-control study, Hydrochlorothiazide users had a 2- to 7-fold increased risk of cutaneous #SCC, with a clear dose-response effect.
😎Patient education on #Sun_avoidance & #Sun_protection is recommended.
ALT https://www.ahajournals.org/doi/epub/10.1161/HYPERTENSIONAHA.123.21274
☀️#Photosensitizers: Common MEDs
💊Antibiotics:
✔︎#Tetracyclines
✔︎#Fluoroquinolones
✔︎#Sulfonamides
💊AntiFungals:
✔︎#Griseofulvin
✔︎#Voriconazole
💊#NSAIDs
💊#Psoralens
💊#Retinoids
💊#Phenothiazines
💊Other:
✔︎#Hydrochlorothiazide
✔︎#Metformin
✔︎#Amiodarone
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
Very valuable overview and interrogation of data. Great work Lee Lab! @Stanford @StanfordMed
@BencomoTomas @CarolynLeeMDPhD Gene expression landscape of cutaneous squamous cell carcinoma progression academic.oup.com/bjd/article…
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
Our first 25 metastatic cSCC WGS 90X/30X.
Plenty to explore including clinical data.
Thanks again to our generous patients who allowed us access to their tumours.
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
Hey mate, this is awesome. I am a B.I. Administrator, with a broad experience in IT from dev/coding to testing to DB work. Happy to discuss offline. :-) I am also currently battling stage 4 metastatic cutaneous scc. I am doing what I can where I can to fight it. Or help out where I can. The only thing holding back the cancer inside my body is an experimental drug where I am part of a clinical trial. Again, happy to discuss offline. Please DM me, Many thanks in advance, mate! 🙏🙏
Limitations of the Commercially Available Gene Expression Test in Predicting Cutaneous Squamous Cell Carcinoma Metastasis and Clinical Outcomes - Journal of the American Academy of Dermatology jaad.org/article/S0190-9622%…
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
With the advent of RNA-based medicine, PVT1 may be a promising molecular target for the management of inoperable or metastatic cutaneous squamous cell carcinoma (cSCC). Increased expression of PVT1 may serve as a biomarker for cSCCs.
doi.org/10.1093/bjd/ljad419
Extrachromosomal DNA in cutaneous squamous cell carcinoma is associated with increased nodal disease biorxiv.org/content/10.1101/…
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
My 1st first author preprint is out! @CarolynLeeMDPhD and I analyzed public RNA-Seq data from 147 cutaneous squamous cell carcinoma (cSCC) samples to create a set of robust differentially expressed genes (DEGs) involved in cSCC pathogenesis
biorxiv.org/content/10.1101/…
🧵 below! /1
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
Expected changes in the Cutaneous Squamous Cell Carcinoma (cSCC) market are driven by improved diagnostics, heightened disease awareness, & upcoming therapy introductions.
Learn more about the key factors that profoundly alter the cSCC market dynamics: tinyurl.com/y23v2khw.
PI3K and CDK inhibitors combo against advanced cutaneous squamous cell carcinoma. mdpi.com/2072-6694/16/2/370
🔬✨Dynamic dance of PI3K and CDK inhibitors against advanced cSCC. @DrJayPerry 🩸🔍 combos show promise, but the road to perfection lies in matching drug specifics to individual mutations. 🧬💊 #CancerResearch #SkinHealth 🌞👩🔬
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
Heading in to #ESMO23 ☀️ 😎 to present updated survival results for the phase 2 trial of #neoadjuvant #immunotherapy in resectable cutaneous #squamous #skin #cancer #cSCC @SquamousCscc @NEJM @AHNSinfo @Regeneron @MDAndersonNews
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic #SkinCancer with high mortality rates. @ElinaSiljamaki et al. identify PLX8394 as a potential therapeutic compound for advanced and metastatic cSCC.
👉nature.com/articles/s41388-0…
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
PD-1-blocking antibodies are approved to treat metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC) ineligible for surgery or radiation. But some patients don’t respond or have severe immune-related adverse events. There is a need for improved therapies. 2/11
cutaneous Squamous Cell Carcinoma (cSCC) Network retweeted
Glad to share our collaborative paper with the group of [email protected] on lncRNA PVT1 in cSCC
Long non-coding RNA PVT1 is overexpressed in cutaneous squamous cell carcinoma and exon 2 is critical for its oncogenicity academic.oup.com/bjd/article…
