The lab of Dr. Nephi Stella studies the molecular mechanism and therapeutic value of cannabinoid-based molecules.
University of Washington
Joined July 2021
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Lab of Dr. Nephi Stella, University of Washington retweeted
Doubling The Amount Of THC In Marijuana Doesn't Get You Twice As High, New Study Shows (Op-Ed): "The high rises quickly at low doses, but extra THC soon adds less and less, which backs the advice to start low and go slow."
marijuanamoment.net/doubling…
Lab of Dr. Nephi Stella, University of Washington retweeted
How does THC affect emotion regulation in PTSD?
THC produced dose-related reductions in prefrontal engagement during negative emotion reappraisal, suggesting a role for cannabinoids in re-engaging efficient emotion regulation strategies in PTSD
nature.com/articles/s41386-0…
Lab of Dr. Nephi Stella, University of Washington retweeted
"These data do not strongly support the use of a single exposure to psychedelics in the treatment of OUD but may suggest persistent effects of psychedelics on heightened pain perception typically observed in opioid withdrawal."
#psychedelics
journals.sagepub.com/doi/10.…
Lab of Dr. Nephi Stella, University of Washington retweeted
A preliminary pharmacodynamic overview of objective measures of intoxication in regular and fast-acting cannabis edibles
link.springer.com/article/10…
Lab of Dr. Nephi Stella, University of Washington retweeted
5-HT2A receptor activation induces CB1-dependent presynaptic inhibitory long-term depression in the nucleus accumbens core
doi.org/10.3389/fphar.2026.1…
Lab of Dr. Nephi Stella, University of Washington retweeted
Cannabidiol attenuates behavioral impairments and deficits in parvalbumin interneurons and their perineuronal nets induced by adolescent stress in adult mice
doi.org/10.1016/j.pnpbp.2026…
Lab of Dr. Nephi Stella, University of Washington retweeted
Acute Ultra Low Dose THC Attenuates Anxiety-Like Behavior in a Mouse Model for Major-Depressive Disorder
doi.org/10.1007/s12031-026-0…
Lab of Dr. Nephi Stella, University of Washington retweeted
So excited to finally share this collaborative work exploring the role of CADM2 recursive splice site deletions led by @Philip_M_Boone. We (@JKhokharLab) were fortunate to characterize the neural and behavioural consequences of CADM2 RS1 deletion cell.com/cell-reports/fullte…
Lab of Dr. Nephi Stella, University of Washington retweeted
This is, frankly, an amazing study. Given ongoing human trials this, I think, provides context,
Stepwise engagement of cingulate ensembles underlies motivational decline in chronic pain: Neuron cell.com/neuron/fulltext/S08…
Lab of Dr. Nephi Stella, University of Washington retweeted
Prediction: no one will care about journal names in 5 years.
Lab of Dr. Nephi Stella, University of Washington retweeted
Cannabinoid modulation of central amygdala population dynamics during threat investigation
nature.com/articles/s41467-0…
Lab of Dr. Nephi Stella, University of Washington retweeted
🐭 Low-THC, CBD-rich hemp oil boosted sociability in mice — no sedation, no side effects. An early lead for conditions like autism.
doi.org/10.1089/can.2021.001…
Lab of Dr. Nephi Stella, University of Washington retweeted
📢 New Study: Cannabis use patterns in cannabinoid hyperemesis syndrome (CHS) 🤢
🔹 Survey of 1,134 respondents
🔹 96.5% used cannabis at least daily; 45% used ≥6 times/day near symptom onset
🔹 Morning nausea & stomach pain were common early symptoms
⚠️ Self-reported observational survey; causality cannot be inferred
➡️ Patterns may support earlier CHS recognition
🔗 f.mtr.cool/tq74o4jj4r
#MedicalCannabis #CannabisResearch #CannabisEducation #CHS #HarmReduction
Lab of Dr. Nephi Stella, University of Washington retweeted
🚨 We're hiring!
The @PainLaboratory at @YalePsych is recruiting a #postdoc in #pain & #addiction neuropsychopharmacology.
Human lab studies of #cannabinoids & #psychedelics:
pharmacokinetics/pharmacodynamics, psychophysics, clinical trials. PhD/MD.
medicine.yale.edu/lab/pain/p…
Lab of Dr. Nephi Stella, University of Washington retweeted
@HutchBasicSci is searching for an associate or senior faculty member! Generous package thanks to donation from Bezos family:apply.interfolio.com/193655. Come join us in Basic Sciences
Lab of Dr. Nephi Stella, University of Washington retweeted
Someone finally ran the control experiment that drug discovery has been skipping for the last fifty years, and the result is going to to make your weekly med chem meetings kind of awkward :)
doi.org/10.1038/s41586-026-1…
Lab of Dr. Nephi Stella, University of Washington retweeted
Anandamide blocks spatial memory reconsolidation in male rats through a CB1 receptor dependent mechanism
doi.org/10.1007/s00213-026-0…
Lab of Dr. Nephi Stella, University of Washington retweeted
📢 New Study: THC and CBD affected rat brain activity differently 🧠
🔹 Preclinical multimodal neuroimaging
🔹 Adult male rats received THC, cannabidiol (CBD), THC:CBD, or vehicle
🔹 THC increased functional connectivity and cerebral blood flow; CBD decreased connectivity without changing blood flow
⚠️ Rat study; findings may not generalize to humans
🔗 f.mtr.cool/9aarwu0fcy
#MedicalCannabis #CannabisResearch #CannabisEducation #Neuroimaging #CBD
Lab of Dr. Nephi Stella, University of Washington retweeted
Great interview between @trikomes and @StellaLab11 about endocannabinoids. Talks a lot about enzymatic conversion and metabolism of anandamide and 2AG. For your listening pleasure:
youtube.com/watch?v=QqQU576h…
