@TGenResearch

A nonprofit institute, translating genomic research into life changing results. TGen is part of City of Hope. Follows & likes are not an endorsement.

 Phoenix, Arizona
tgen.org
Joined February 2009
  • Tweets12.5K
  • Following844
  • Followers4.9K
2.9KMedia
Researchers discovered 11 special proteins hidden inside tiny particles floating in our blood. As liver damage gets worse, the protein levels go up—making it easier to tell the difference between severe liver damage and full-blown cirrhosis. bit.ly/4ygqEb6
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Jenny Paredes, PhD, is not new to the research realm at TGen, we are thrilled to celebrate her appointment as an assistant professor in the Immunology and Microbiome Division and co-director of TGen's Integrated Microbiomics Center. She also heads the microbiome team @cityofhope
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A new study has found a clue as to why some people get cancer while others don't. Scientists found that some healthy people have up to 8x more mutations than others! Measuring a person's baseline mutation rate could help drs identify people at higher risk. bit.ly/3UkrINa
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Our postdocs found a unique way to bring life to their workspaces... Each made their own terrarium to out of beakers 🌱 👨🏽‍🔬 🧫 Very clever. #TGen #postdoc #fyp
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Current diagnostic tools for heart transplant rejection rely heavily on histology, which often misses critical molecular details. A new study using subcellular spatial transcriptomics on cardiac biopsies from 62 recipients is changing the game go.nature.com/4cEGq7N @NeBanovich
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Congratulations to TGen's Samantha O'Connor, PhD, a postdoctoral fellow in the Pirrotte Lab, part of the Early Detection and Prevention Division. Dr. O'Connor received the "Best Poster Award" at the 2026 European Symposium on Single Cell Proteomics in Vienna.
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COSIGT is a tool that maps short-read sequence data to a pangenome graph using cosine similarity metrics. 3/4
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Why this matters: -Accurately genotypes complex loci from shallow data -Reduces sequencing costs -Opens up new possibilities for ancient DNA & large biobanks -Improves mapping of medically relevant genetic variation 4/4
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Genotyping complex, highly variable regions of the human genome has always been a challenge—especially with limited or low-coverage DNA. Read the full paper: doi.org/10.1186/s13059-026-0… #Genomics #DNA #Pangenome #TGen 1/4

COSIGT: population-scalable genotyping of complex loci from low-coverage sequencing data using...

Genome Biology - Pangenome graphs capture extensive structural diversity, but resolving complex loci from shallow sequencing remains challenging, particularly when samples are of low quality such...

link.springer.com
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TGen's Andrea Guarracino, PhD, along with Davide Bolognini, PhD, from Human Technopole, have recently published a new study in Genome Biology that introduces COSIGT (COsine SImilarity-based GenoTyper). 2/4
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The collaboration with our colleagues across the Valley to grow the bioscience and healthcare for the future of Arizona is crucial 🌵🧬
Greater Phoenix Economic Council
@GPECSep 7
Companies like @TGenResearch, @MayoClinicand @BannerHealth are contributing to the bioscience and healthcare pipeline that starts in K-12 and goes through graduate programs. gpec.org/blog/inside-greater…
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We are thrilled to welcome @HBorgesdaSilva to TGen. The knowledge and opportunity for innovation are endless. 🧬 👏🏼 🔬🥼
Henrique Borges da Silva@HBorgesdaSilvaSep 4
Last week I ended my 6-year chapter @MayoClinic. I will miss all my friends and colleagues there! Our lab now is 30 min south, in downtown Phoenix! I’m now an Associate Professor @TGenResearch in the Immunology and Microbiome Division! Super excited for our next chapters!
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August was a busy month for research at TGen. Hear how scientists are exploring areas of Alzheimer's disease, dementia, and Parkinson's disease. As well as how to better understand heart transplant rejection by identifying the cell types present. ➡️ bit.ly/464uMPW

Research: Study looks at heart transplant rejection at the molecular and cellular level

When a transplanted heart begins to show signs of rejection, doctors rely on tissue biopsies to assess what is happening. But a new study suggests that the image under the microscope may not tell the...

linkedin.com
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TGen’s Dr. John Fryer recently sat down for a TGen Talks podcast on the power of mentoring in science. It’s a great reminder that behind every breakthrough is someone who took the time to encourage the next generation. Listen at: bit.ly/4bAl6zE
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2026 marks the 20th anniversary of the partnership between TGen and Helios Education Foundation. Lauren Brito Siddall, 2008 scholar, was able to expand the program and learn more about the intersection of business and healthcare. #TGen #Helios #Internship #Impact #Research
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The @US_FDA approval of daraxonrasib marks an important new chapter for patients facing metastatic pancreatic cancer. @cityofhope was proud to be among 59 centers worldwide that enrolled patients in the landmark clinical trial that helped bring this therapy forward.
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👏🏼 @jmikhaelmd sharing his insights and more on #multiplemyeloma #TGen #CityOfHope #IMF
Oncology Brothers
@OncBrothersAug 24
Rapid Fire Rounds (where we address 10-12 pin pointed clinical questions/cases from the community). Here is our first 🗣️ in #MultipleMyeloma w/ @jmikhaelmd! Full 🗣️: ⭐️ oncbrothers.com/rfr-myeloma-… ⭐️ Also on “Oncology Brothers” podcast @OncUpdates #OncTwitter #HemeTwitter
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Rapid Fire Rounds (where we address 10-12 pin pointed clinical questions/cases from the community). Here is our first 🗣️ in #MultipleMyeloma w/ @jmikhaelmd! Full 🗣️: ⭐️ oncbrothers.com/rfr-myeloma-… ⭐️ Also on “Oncology Brothers” podcast @OncUpdates #OncTwitter #HemeTwitter
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What Makes a Great Science Mentor? Dr. Fryer shares his six tips to remember. #TGen #Mentorship
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Researchers at TGen have developed a novel "dual-chemistry" method for @10xGenomics Xenium that removes the trade-off between sensitivity and gene coverage—allowing both to be analyzed on a single tissue section. 🔗 bit.ly/4gebH27 #Genomics @NeBanovich
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