@TheHurleyLab

The Hurley Lab @UCBerkeley @berkeleyMCB #autophagy #StructuralBiology #CryoEM #Membranes #xraycrystallography #OpticalTweezers. Tweets by @AutophaZeke or Jim

 Berkeley, CA
membrane.berkeley.edu
Joined July 2019
  • Tweets567
  • Following333
  • Followers2K
86Media
Structural-functional dissection of arginine sensing by CASTOR1 and its interaction with GATOR2 to regulate mTORC1 signaling, led by Rachel Jansen @TheHurleyLab lab with help from Z-lab postdoc Clement Maghe: tinyurl.com/yr6en6f4
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Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio.
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Hurley Lab retweeted
mito911@mito911_10 Sep 2024
📣New @biorxivpreprint by Leo (Wai Kit) Lam Runa Lindblom @LazarouLab @mito911_ and collaborators. Check it out! ➡️biorxiv.org/content/10.1101/…

Presynapses are mitophagy pit stops that prevent axon degeneration

Defects in neuronal mitophagy have been linked to neurodegenerative diseases including Parkinson’s disease. However, despite the importance of mitophagy in neuronal homeostasis, the mechanistic basis...

biorxiv.org
Michael Lazarou@LazarouLab10 Sep 2024
Our latest preprint! Some beautiful cell biology in this one. "Presynapses are mitophagy pit stops that prevent axon degeneration" biorxiv.org/cgi/content/shor… Discoveries into the cell biology of of mitophagy in axons, a disease mechanism, and a potential therapeutic avenue. 1/2
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We're Hiring! Assistant Professor of Biochemistry, Biophysics, and Structural Biology in MCB. Learn more and apply online: aprecruit.berkeley.edu/JPF04…
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Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery dlvr.it/TCV4hc
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Hurley Lab retweeted
mito911@mito911_20 Aug 2024
Join us for the upcoming @mito911_ Zoom Webinar by Prof. Michael Clague @LivUni! 📅Sept 10th 2024 ⏲️4pm BST 📝us06web.zoom.us/webinar/regi… @ASAP_Research @MichaelJFoxOrg
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Thought you should know, the cryo-EM structure was solved by @MinghaoChen10 and preprinted on Jun. 1, 2023 tinyurl.com/36ddb7p9 and the cryo-EM coordinates of the same complex were released on Jun. 23, 2023 rcsb.org/structure/8SOI .
Yutaro HAMA@YHama01053 Aug 2024
Our new preprint has been published. This is my first work from the @NodannL . We have elucidated the mechanism of ULK complex formation through in vivo and in vitro experiments based on AlphaFold-predicted structure.
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**MEETING ALERT** @BiochemSoc @ASAP_Research 20th Anniversary meeting on #PINK1 mutations in #Parkinsons. Fantastic lineup of speakers; industry and clinical talks and many early-career speaker slots. To register and learn more click: shorturl.at/LnXZM
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Congratulations to all of you.
mito911@mito911_25 Jun 2024
📣New article by @EliasAdriaensse @ThanhNguyen_TNN @martens_sascha @LazarouLab @mito911_ on fine regulation of #mitophagy initiation by NAP1 and SINTBAD now published in @NatureSMB ! With the amazing support of @ASAP_Research @MichaelJFoxOrg nature.com/articles/s41594-0…

Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

Nature Structural & Molecular Biology - Mitophagy is an important quality control pathway. Here, the authors identify the mechanisms enabling the TBK1 adaptors NAP1 and SINTBAD to prevent...

nature.com
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There is still time for abstract submission! Please, share! 😊
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Watch for a tweetorial from @kevinrosem in our lab- coming soon
Cell Biology J-Club@cell_club24 May 2024
Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes | PNAS pnas.org/doi/10.1073/pnas.23…

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes | PNAS

The prion-like spread of protein aggregates is a leading hypothesis for the propagation of neurofibrillary lesions in the brain, including the spre...

pnas.org
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Welcome to the EMBO Workshop Autophagy across scales at Sorrento, Italy, Sept 23-27. Remember to sign up! @WAutophagy @CanCell_UiO @AutophagyNordic @AIM_autophagy @EMBO meetings.embo.org/event/24-a…

Autophagy across scales

Autophagy, a cornerstone of cellular quality control, has seen remarkable breakthroughs since the discovery of Autophagy-related genes in the 1990s. Recent advancements reveal a mechanistically plaus…

meetings.embo.org
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Attention new or recent grads: we are hiring for a tech position to support a new ALS drug discovery project. tinyurl.com/2en7p384
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Yay us! Go Bears!
Robert Sanders@bobthesciguy24 Apr 2024
Congratulations to the 7 @UCBerkeley scientists elected today to the American Academy of Arts and Sciences news.berkeley.edu/2024/04/24…

Seven UC Berkeley scientists elected to the American Academy of Arts and Sciences - Berkeley News

Seven UC Berkeley scientists — including a chemist, a psychologist, an engineer, two biologists and two physicists — are among 250 new members elected to the American Academy of Arts and Sciences t...

news.berkeley.edu
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Lucky to see baby giant pandas wrestling on visit to Chengdu hosted by Hurley lab alumnus Shiqian Qi.
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Hurley lab #Eclipse2024 watching in Berkeley. Partial was good enough to bring lots of smiles and oohs and ahhs.
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Such an honor to serve as vice-chair for an incredible meeting led by @patricia_boya and @TheHurleyLab Looking forward to chairing the 2026 meeting with Oliver @FloreyLab and new vice-chairs Roberto and Helene @RobertoZoncu @KnVelsrud #GRCautophagy2024
Patricia Boya@patricia_boya15 Mar 2024
Great week at the #GRCAutophagy2024 . Amazing science, great discussions and fun. Thanks to co-chair Jim Hurley @TheHurleyLab and vice-chair @rushika_perera for a great team effort. Safe trip home!
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Excited to share the fantastic program for this year's Lysosomes & Endocytosis Gordon Conference Great speakers, fast-moving science, and wonderful community. Apply soon for best availability! June 16-21 (with GRS June 15-16), Proctor Academy grc.org/lysosomes-and-endocy…
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🚨Now in print!🚨Sankalp Shukla @Sankalp Shukla_ in collaboration with @PIHanson lab and @HummerLab probes the mechanistic and cellular implications of direct membrane binding by the ESCRT and ERES associated Ca2+- sensor ALG- 2 protein. Read it: pnas.org/doi/10.1073/pnas.23… @PNASNews

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated...

Apoptosis linked Gene-2 (ALG-2) is a multifunctional intracellular Ca2+ sensor and the archetypal member of the penta-EF hand protein family. ALG-2...

pnas.org
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Hurley Lab retweeted
mito911@mito911_15 Feb 2024
🚨In 1 week⬇️ @mito911_ Webinar by @patricia_boya on Feb 22nd at 4pm BST on "Mitophagy, mtDNA and inflammaging". Register here to attend: us06web.zoom.us/webinar/regi…
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